SRP68_DEBHA
ID SRP68_DEBHA Reviewed; 587 AA.
AC Q6BMV4;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Signal recognition particle subunit SRP68;
DE AltName: Full=Signal recognition particle 68 kDa protein homolog;
GN Name=SRP68; OrderedLocusNames=DEHA2F02354g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC ribonucleoprotein complex that mediates the cotranslational targeting
CC of secretory and membrane proteins to the endoplasmic reticulum (ER)
CC (By similarity). The SRP complex interacts with the signal sequence in
CC nascent secretory and membrane proteins and directs them to the
CC membrane of the ER (By similarity). The SRP complex targets the
CC ribosome-nascent chain complex to the SRP receptor (SR), which is
CC anchored in the ER, where SR compaction and GTPase rearrangement drive
CC cotranslational protein translocation into the ER (By similarity).
CC Binds the 7SL RNA, srp72 binds to this complex subsequently (By
CC similarity). The SRP complex possibly participates in the elongation
CC arrest function (By similarity). {ECO:0000250|UniProtKB:P38687,
CC ECO:0000250|UniProtKB:Q9UHB9}.
CC -!- SUBUNIT: Heterodimer with SRP72 (By similarity). SRP68-SRP72
CC heterodimer formation is stabilized by the presence of 7SL RNA (By
CC similarity). Component of a fungal signal recognition particle (SRP)
CC complex that consists of a 7SL RNA molecule (scR1) and at least six
CC protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14 (By
CC similarity). {ECO:0000250|UniProtKB:P38687,
CC ECO:0000250|UniProtKB:Q00004, ECO:0000250|UniProtKB:Q9UHB9}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O74436}.
CC Nucleus, nucleolus {ECO:0000250|UniProtKB:P38687}. Endoplasmic
CC reticulum {ECO:0000250|UniProtKB:Q9UHB9}.
CC -!- SIMILARITY: Belongs to the SRP68 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAG88773.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CR382138; CAG88773.2; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_460466.2; XM_460466.2.
DR AlphaFoldDB; Q6BMV4; -.
DR SMR; Q6BMV4; -.
DR STRING; 4959.XP_460466.2; -.
DR EnsemblFungi; CAG88773; CAG88773; DEHA2F02354g.
DR GeneID; 2903971; -.
DR KEGG; dha:DEHA2F02354g; -.
DR eggNOG; KOG2460; Eukaryota.
DR HOGENOM; CLU_018649_2_1_1; -.
DR InParanoid; Q6BMV4; -.
DR OrthoDB; 1019762at2759; -.
DR Proteomes; UP000000599; Chromosome F.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-KW.
DR GO; GO:0008312; F:7S RNA binding; IEA:InterPro.
DR GO; GO:0030942; F:endoplasmic reticulum signal peptide binding; IEA:InterPro.
DR GO; GO:0005047; F:signal recognition particle binding; IEA:InterPro.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR CDD; cd15481; SRP68-RBD; 1.
DR Gene3D; 1.10.3450.40; -; 1.
DR InterPro; IPR026258; SRP68.
DR InterPro; IPR034652; SRP68-RBD.
DR InterPro; IPR038253; SRP68_N_sf.
DR PANTHER; PTHR12860; PTHR12860; 1.
DR Pfam; PF16969; SRP68; 1.
DR PIRSF; PIRSF038995; SRP68; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Endoplasmic reticulum; Nucleus; Reference proteome;
KW Ribonucleoprotein; RNA-binding; Signal recognition particle.
FT CHAIN 1..587
FT /note="Signal recognition particle subunit SRP68"
FT /id="PRO_0000135231"
FT REGION 553..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 587 AA; 67409 MW; A03325959EEA7706 CRC64;
MSAYLSSSED YHKQRKRLNK RLLKLRHELD LITPDTKDYK KKEKISKISS SDYDQDEKYG
LLLLLTAERD SLYSSEIKSL LEISNDNASS YRNLMISRIK KSLSSSKKLL EITVNEKDEY
KRIEYYTYAA LIQGNLSVNK KQWSKALNAF SIAKCALDFL YSQEDSKMDI EEEQEESTQF
KKTLISEITE TLVDPSLALA ISQDDTAYST TTDLKTVSRQ HCRDNKLSYL QPVIEIIARI
DPEAVSEVSS STELIKSVQW RDHEATLYND ELAYKIMKLT NDNETNWKNF NDANQFDVLL
SGWSELLEIH TNDMDKNKDE DDLEKVQDRA IVLTYINFNL LFTRLKRDLL IIDQLSSQGD
NVFALKKLEF NKDIIRLYGT IITTTQEIKD LPGVYNDEDL HESLDNLEKF FVAKKSAVLA
RSFALNNKFP EALKIFDHVD NTLSSSDNKF YKIDEFPYNV SSNVEFEKFK KELPSQVLQA
QILAQFSVDL SKNLNQSNFV IENMNKYPVS NETLDNIANF NKNLSIAPVL SKPVLFDIGF
NYINYGMGRS SSYNNSNSAT STTSDSTTDQ NDPNKKKSGF FGIFGRS
