SRP72_CAEEL
ID SRP72_CAEEL Reviewed; 635 AA.
AC P91240;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Signal recognition particle subunit SRP72;
DE Short=SRP72;
DE AltName: Full=Signal recognition particle 72 kDa protein homolog;
GN Name=srpa-72 {ECO:0000312|WormBase:F08D12.1};
GN ORFNames=F08D12.1 {ECO:0000312|WormBase:F08D12.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC ribonucleoprotein complex that mediates the cotranslational targeting
CC of secretory and membrane proteins to the endoplasmic reticulum (ER)
CC (By similarity). The SRP complex interacts with the signal sequence in
CC nascent secretory and membrane proteins and directs them to the
CC membrane of the ER (By similarity). The SRP complex targets the
CC ribosome-nascent chain complex to the SRP receptor (SR), which is
CC anchored in the ER, where SR compaction and GTPase rearrangement drive
CC cotranslational protein translocation into the ER (By similarity).
CC Binds the signal recognition particle RNA (7SL RNA) in presence of
CC srpa-68 (By similarity). Can bind 7SL RNA with low affinity (By
CC similarity). The SRP complex possibly participates in the elongation
CC arrest function (By similarity). {ECO:0000250|UniProtKB:O76094,
CC ECO:0000250|UniProtKB:P38688}.
CC -!- SUBUNIT: Heterodimer with srpa-68 (By similarity). Srpa-68-srpa-72
CC heterodimer formation is stabilized by the presence of 7SL RNA (By
CC similarity). Component of a signal recognition particle (SRP) complex
CC that consists of a 7SL RNA molecule of 300 nucleotides and six protein
CC subunits: srpa-72, srpa-68, SRP54, F37F2.2/SRP19, F25G6.8/SRP14 and
CC ZK512.4/SRP9 (By similarity). Within the SRP complex, interacts (via N-
CC terminus) with srpa-68 (via C-terminus) (By similarity).
CC {ECO:0000250|UniProtKB:O76094, ECO:0000250|UniProtKB:P33731}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O76094}.
CC Endoplasmic reticulum {ECO:0000250|UniProtKB:O76094}.
CC -!- SIMILARITY: Belongs to the SRP72 family. {ECO:0000305}.
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DR EMBL; FO081086; CCD69012.1; -; Genomic_DNA.
DR PIR; T25685; T25685.
DR RefSeq; NP_494366.2; NM_061965.5.
DR AlphaFoldDB; P91240; -.
DR SMR; P91240; -.
DR BioGRID; 38989; 8.
DR STRING; 6239.F08D12.1; -.
DR EPD; P91240; -.
DR PaxDb; P91240; -.
DR PeptideAtlas; P91240; -.
DR EnsemblMetazoa; F08D12.1.1; F08D12.1.1; WBGene00017245.
DR GeneID; 173625; -.
DR KEGG; cel:CELE_F08D12.1; -.
DR UCSC; F08D12.1; c. elegans.
DR CTD; 173625; -.
DR WormBase; F08D12.1; CE41557; WBGene00017245; srpa-72.
DR eggNOG; KOG2376; Eukaryota.
DR GeneTree; ENSGT00390000013264; -.
DR HOGENOM; CLU_013808_1_0_1; -.
DR InParanoid; P91240; -.
DR OMA; NDMKVLA; -.
DR OrthoDB; 743414at2759; -.
DR PhylomeDB; P91240; -.
DR Reactome; R-CEL-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR PRO; PR:P91240; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00017245; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IBA:GO_Central.
DR GO; GO:0008312; F:7S RNA binding; IBA:GO_Central.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR013699; Signal_recog_part_SRP72_RNA-bd.
DR InterPro; IPR026270; SRP72.
DR InterPro; IPR031545; SRP_TPR-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR14094; PTHR14094; 1.
DR Pfam; PF08492; SRP72; 1.
DR Pfam; PF17004; SRP_TPR_like; 1.
DR PIRSF; PIRSF038922; SRP72; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; SSF48452; 2.
PE 3: Inferred from homology;
KW Cytoplasm; Endoplasmic reticulum; Reference proteome; Repeat;
KW Ribonucleoprotein; Signal recognition particle; TPR repeat.
FT CHAIN 1..635
FT /note="Signal recognition particle subunit SRP72"
FT /id="PRO_0000135235"
FT REPEAT 7..42
FT /note="TPR 1"
FT REPEAT 75..105
FT /note="TPR 2"
FT REPEAT 106..139
FT /note="TPR 3"
FT REPEAT 171..204
FT /note="TPR 4"
FT REPEAT 220..253
FT /note="TPR 5"
FT REPEAT 255..290
FT /note="TPR 6"
FT REPEAT 436..469
FT /note="TPR 7"
FT REGION 539..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 635 AA; 71414 MW; FCAFB4B39F1D71A1 CRC64;
MADASAGGLY QCLTDISRAD TSGDYQKALT SANKLIRKYP KETFAFKCKL VAQIQLSQYA
DALELIRKTP AHQMGHVGFE KAYIHYRQDE LDEAIKELNT CDKDDVKALE LKAQVFYKQE
NYQQAYDIYL YLLKNHSDDS DELRRANFLA VQARLEAQGV KQAVAETEDS YSQLYNRACV
EIEAEKLPQA LESLEKALKT CRKSFEDEDR EEDEIEEELD SIRVQKAYVL QRMGQKAEAL
AIYEKVQAAN HPDSSVKATI TNNIPAASSD FALPESRKRF KAALQIDQTK LTRRQRLTLM
LNNALVLLLS NQREPCKRAL EELVAKFGSS KDVALIEATL HFKMGDAEAA LKVLAGSDLE
QSLARLHVLL NAGRLPEAVG AIRDLPISGK LGASSLLTST LIAADSRDEA VKELVAASTA
KNQTPEALKS ILEDLVEVEQ QRGNETAATK HLEKLVEKFP EDLQLQCRLV GAYSKTDPKK
AESLSAKLFP ETMEVDVNVD ELEDSDWILY GEKYRQKKEA KSPQTAEIAA TRKLKIATKR
KRKIRLPKNY NSAVTPDPER WLPRQERSTY KRKRKNRERE IGRGTQGSSS ANPNVEYVTA
SPNSPRPLPG PVAEGPRQQR PNFQKQKKKK NASKF
