SRP72_DICDI
ID SRP72_DICDI Reviewed; 672 AA.
AC Q54EP7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Signal recognition particle subunit SRP72;
DE AltName: Full=Signal recognition particle 72 kDa protein homolog;
GN Name=srp72; ORFNames=DDB_G0291412;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC ribonucleoprotein complex that mediates the cotranslational targeting
CC of secretory and membrane proteins to the endoplasmic reticulum (ER)
CC (By similarity). Binds the 7SL RNA in presence of srp68 (By
CC similarity). This ribonucleoprotein complex might interact directly
CC with the docking protein in the ER membrane and possibly participates
CC in the elongation arrest function (By similarity).
CC {ECO:0000250|UniProtKB:P38688}.
CC -!- SUBUNIT: Component of a signal recognition particle (SRP) complex that
CC consists of a 7SL RNA molecule and six protein subunits: srp72, srp68,
CC srp54, srp19, srp14 and srp9. {ECO:0000250|UniProtKB:P38688}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O76094}.
CC Endoplasmic reticulum {ECO:0000250|UniProtKB:O76094}.
CC -!- DOMAIN: The C-terminus is essential for the interaction with the
CC srp68/7SL RNA complex. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SRP72 family. {ECO:0000305}.
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DR EMBL; AAFI02000177; EAL61690.1; -; Genomic_DNA.
DR RefSeq; XP_635193.1; XM_630101.1.
DR AlphaFoldDB; Q54EP7; -.
DR SMR; Q54EP7; -.
DR STRING; 44689.DDB0232384; -.
DR PaxDb; Q54EP7; -.
DR PRIDE; Q54EP7; -.
DR EnsemblProtists; EAL61690; EAL61690; DDB_G0291412.
DR GeneID; 8628138; -.
DR KEGG; ddi:DDB_G0291412; -.
DR dictyBase; DDB_G0291412; srp72.
DR eggNOG; KOG2376; Eukaryota.
DR HOGENOM; CLU_013808_1_0_1; -.
DR InParanoid; Q54EP7; -.
DR OMA; NDMKVLA; -.
DR PhylomeDB; Q54EP7; -.
DR Reactome; R-DDI-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR PRO; PR:Q54EP7; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; ISS:dictyBase.
DR GO; GO:0008312; F:7S RNA binding; IBA:GO_Central.
DR GO; GO:0005047; F:signal recognition particle binding; ISS:dictyBase.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR013699; Signal_recog_part_SRP72_RNA-bd.
DR InterPro; IPR026270; SRP72.
DR InterPro; IPR031545; SRP_TPR-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR14094; PTHR14094; 1.
DR Pfam; PF08492; SRP72; 1.
DR Pfam; PF17004; SRP_TPR_like; 1.
DR PIRSF; PIRSF038922; SRP72; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS50005; TPR; 4.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 3: Inferred from homology;
KW Cytoplasm; Endoplasmic reticulum; Reference proteome; Repeat;
KW Ribonucleoprotein; RNA-binding; Signal recognition particle; TPR repeat.
FT CHAIN 1..672
FT /note="Signal recognition particle subunit SRP72"
FT /id="PRO_0000328095"
FT REPEAT 9..42
FT /note="TPR 1"
FT REPEAT 43..76
FT /note="TPR 2"
FT REPEAT 78..104
FT /note="TPR 3"
FT REPEAT 105..137
FT /note="TPR 4"
FT REPEAT 140..173
FT /note="TPR 5"
FT REPEAT 223..256
FT /note="TPR 6"
FT REPEAT 269..302
FT /note="TPR 7"
FT REPEAT 386..420
FT /note="TPR 8"
FT REPEAT 421..454
FT /note="TPR 9"
FT REPEAT 465..498
FT /note="TPR 10"
FT REPEAT 522..555
FT /note="TPR 11"
FT REGION 552..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 672 AA; 76125 MW; CF22CCC2AB302F81 CRC64;
MSKDTTVSLE QLFKELDEYI INSQFKKAIR VCNKILSVNG NDSEAFQCKV ICLMQLSNFT
EAIECFKKPE QIQSMQFEYS YCLYSTAKYQ EALTQLEKQS SKETKSLELE AQIYYKLENY
QKTISIYESL LSKPGYSDSI EFITNLCAVY LDAGKFNECQ ELLNKNKSQQ TKTHELAFNS
ACLAISKNDT KTAETQLKLA KKICTDSLKK DGFSEEEIKE EQTSIDVQLG YVQQICGNLE
KSLEQYQNVL EQQVGDSATL VATNNSISVR SILQSDQWST QPKEYTHAMD SLKSLLTEAE
STRLNSKQKK VINYNLCLLL VQLKKVSQCE ELIKTLKSKY GQQQQQVDTS FVEDLDIIQV
SLLIKEKKFK DAEKLLLKNN TTTGSIKSQL LLAQIYLLDN NNVAKALNVL EKLDSSVSLR
PGIVATKVAL YEKSGDLEKA VNSLDDLISI FDKQKKSEKD EEIYVNLLKA SGNFKLKHHK
YREASDMFDR VLKINPNDLI ALPSYIVATS HFDPSLSQKY EGKLPNIKFE SKIDIDLIEK
YGLTFEKKLN LNEDSNSSSP TTTTTTTTKS TKPTATEVVK IKKSKKKLPK VMKPNYVPDP
GRWLPKWQRA NAKAARSKKN KDIIKGPQGI ASASQTASLF VQESKNTNTN NNNTQSSKSE
KPRNIHKKKS KK
