ID   SRPB_SCHPO              Reviewed;         227 AA.
AC   O13950; Q9USB4;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Signal recognition particle receptor subunit beta;
DE            Short=SR-beta;
GN   Name=srp102; ORFNames=SPAC23H4.07c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 57-195, AND SUBCELLULAR
RP   LOCATION.
RC   STRAIN=ATCC 38364 / 968;
RX   PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA   Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA   Hiraoka Y.;
RT   "Large-scale screening of intracellular protein localization in living
RT   fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL   Genes Cells 5:169-190(2000).
CC   -!- FUNCTION: Component of the signal recognition particle (SRP) complex
CC       receptor (SR) (By similarity). Ensures, in conjunction with the SRP
CC       complex, the correct targeting of the nascent secretory proteins to the
CC       endoplasmic reticulum membrane system (By similarity). May mediate the
CC       membrane association of SR (By similarity).
CC       {ECO:0000250|UniProtKB:P47758}.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC       {ECO:0000250|UniProtKB:P36057}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:10759889}; Single-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the SRP receptor beta subunit family.
CC       {ECO:0000305}.
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DR   EMBL; CU329670; CAB11661.1; -; Genomic_DNA.
DR   EMBL; AB027896; BAA87200.1; -; Genomic_DNA.
DR   PIR; T38321; T38321.
DR   RefSeq; NP_593399.1; NM_001018831.2.
DR   AlphaFoldDB; O13950; -.
DR   SMR; O13950; -.
DR   STRING; 4896.SPAC23H4.07c.1; -.
DR   MaxQB; O13950; -.
DR   PaxDb; O13950; -.
DR   EnsemblFungi; SPAC23H4.07c.1; SPAC23H4.07c.1:pep; SPAC23H4.07c.
DR   GeneID; 2541760; -.
DR   KEGG; spo:SPAC23H4.07c; -.
DR   PomBase; SPAC23H4.07c; srp102.
DR   VEuPathDB; FungiDB:SPAC23H4.07c; -.
DR   eggNOG; KOG0090; Eukaryota.
DR   HOGENOM; CLU_1215204_0_0_1; -.
DR   InParanoid; O13950; -.
DR   OMA; ACNKFDL; -.
DR   PhylomeDB; O13950; -.
DR   PRO; PR:O13950; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005785; C:signal recognition particle receptor complex; ISO:PomBase.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005047; F:signal recognition particle binding; ISO:PomBase.
DR   GO; GO:0045047; P:protein targeting to ER; IBA:GO_Central.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IC:PomBase.
DR   CDD; cd04105; SR_beta; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR019009; SRP_receptor_beta_su.
DR   PANTHER; PTHR11485:SF34; PTHR11485:SF34; 1.
DR   Pfam; PF09439; SRPRB; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; GTP-binding; Membrane; Nucleotide-binding; Receptor;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..227
FT                   /note="Signal recognition particle receptor subunit beta"
FT                   /id="PRO_0000101229"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         44..52
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         65..68
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         87
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   227 AA;  25612 MW;  814ED594E4F8C97F CRC64;
     MDGTSQAFKI IVATIIIGAI ISTLGIFFTR KTIQKKLPAV FLIGPSDSGK TSLFCELIYK
     EKKTTVPSIE PNEAVWKYGA WLVDLPGHPR AKRWITTKFS GNYNVKAVVF VLNSATIDRD
     VHEVGLMLFD TILKCRKHHV PHLLIACNKF DLFTAQPAEK IQQLLKAELH NILEEKNLQL
     ESIVSEDVDW ESVADQIEDT DLKFLPGSVA KMSNIEEWIS WMESALQ