ID   SRPL_CHLTH              Reviewed;         150 AA.
AC   P18587;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Sulfur-rich protein, serovars L1/L3;
DE   AltName: Full=15 kDa cysteine-rich outer membrane protein;
DE   AltName: Full=Cysteine-rich protein A;
GN   Name=srp; Synonyms=crpA;
OS   Chlamydia trachomatis.
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=L1/440/LN;
RX   PubMed=3066701; DOI=10.1016/0378-1119(88)90047-9;
RA   Clarke I.N., Ward M.E., Lambden P.R.;
RT   "Molecular cloning and sequence analysis of a developmentally regulated
RT   cysteine-rich outer membrane protein from Chlamydia trachomatis.";
RL   Gene 71:307-314(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=L3/404;
RX   PubMed=1997423; DOI=10.1128/iai.59.3.1196-1201.1991;
RA   de la Maza L.M., Fiedler T.J., Carlson E.J., Markoff B.A., Peterson E.M.;
RT   "Sequence diversity of the 60-kilodalton protein and of a putative 15-
RT   kilodalton protein between the trachoma and lymphogranuloma venereum
RT   biovars of Chlamydia trachomatis.";
RL   Infect. Immun. 59:1196-1201(1991).
RN   [3]
RP   LOCALIZATION TO INCLUSION MEMBRANES.
RC   STRAIN=L2/434/Bu;
RX   PubMed=11207561; DOI=10.1046/j.1462-5822.2000.00029.x;
RA   Bannantine J.P., Griffiths R.S., Viratyosin W., Brown W.J., Rockey D.D.;
RT   "A secondary structure motif predictive of protein localization to the
RT   chlamydial inclusion membrane.";
RL   Cell. Microbiol. 2:35-47(2000).
RN   [4]
RP   RECOGNITION BY CD8+ T-CELLS.
RC   STRAIN=L2/434/Bu;
RX   PubMed=14568950; DOI=10.4049/jimmunol.171.9.4742;
RA   Starnbach M.N., Loomis W.P., Ovendale P., Regan D., Hess B., Alderson M.R.,
RA   Fling S.P.;
RT   "An inclusion membrane protein from Chlamydia trachomatis enters the MHC
RT   class I pathway and stimulates a CD8+ T cell response.";
RL   J. Immunol. 171:4742-4749(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Note=Immunolocalizes to the inclusion membrane,
CC       the membrane that surrounds the intracellular parasite
CC       (PubMed:11207561). This protein is recognized by CD8+ T-cells in both
CC       human and mouse infections, suggesting it gains access to the host
CC       cytoplasm (PubMed:14568950). {ECO:0000269|PubMed:11207561,
CC       ECO:0000269|PubMed:14568950}.
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DR   EMBL; M35148; AAA23120.1; -; Genomic_DNA.
DR   EMBL; X54390; CAA38262.1; -; Genomic_DNA.
DR   PIR; JT0420; JT0420.
DR   AlphaFoldDB; P18587; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019867; C:outer membrane; IEA:InterPro.
DR   InterPro; IPR008436; CRPA.
DR   Pfam; PF05745; CRPA; 1.
PE   4: Predicted;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..150
FT                   /note="Sulfur-rich protein, serovars L1/L3"
FT                   /id="PRO_0000207125"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   150 AA;  15836 MW;  104D384C2332DB65 CRC64;
     MSTVPVVQGA GSSNSAQDIS TSSVPLTLQG RISNLLSSTA FKVGLVVMGL LLVMATIFLV
     SAASFVNPIY LAIPAIVGCV NICVGILSME GYCSPERWSL CKKVLKASED IIDDGQINNS
     NKVFTDERLN AIGGVVESLS RRNSLVDQTQ