ID   SRPRB_DICDI             Reviewed;         290 AA.
AC   Q54XX1;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Signal recognition particle receptor subunit beta;
DE            Short=SR-beta;
GN   Name=srprb; ORFNames=DDB_G0278543;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the signal recognition particle (SRP) complex
CC       receptor (SR) (By similarity). Ensures, in conjunction with the SRP
CC       complex, the correct targeting of the nascent secretory proteins to the
CC       endoplasmic reticulum membrane system (By similarity). May mediate the
CC       membrane association of SR (By similarity).
CC       {ECO:0000250|UniProtKB:P47758}.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC       {ECO:0000250|UniProtKB:P36057}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:O13950}; Single-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the SRP receptor beta subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000023; EAL68444.1; -; Genomic_DNA.
DR   RefSeq; XP_642431.1; XM_637339.1.
DR   AlphaFoldDB; Q54XX1; -.
DR   SMR; Q54XX1; -.
DR   STRING; 44689.DDB0232374; -.
DR   PaxDb; Q54XX1; -.
DR   EnsemblProtists; EAL68444; EAL68444; DDB_G0278543.
DR   GeneID; 8621636; -.
DR   KEGG; ddi:DDB_G0278543; -.
DR   dictyBase; DDB_G0278543; srpRB.
DR   eggNOG; KOG0090; Eukaryota.
DR   HOGENOM; CLU_961161_0_0_1; -.
DR   InParanoid; Q54XX1; -.
DR   OMA; NKQDVAM; -.
DR   PhylomeDB; Q54XX1; -.
DR   PRO; PR:Q54XX1; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005785; C:signal recognition particle receptor complex; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0045047; P:protein targeting to ER; IBA:GO_Central.
DR   CDD; cd04105; SR_beta; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR019009; SRP_receptor_beta_su.
DR   PANTHER; PTHR11485:SF34; PTHR11485:SF34; 1.
DR   Pfam; PF09439; SRPRB; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; GTP-binding; Membrane; Nucleotide-binding; Receptor;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..290
FT                   /note="Signal recognition particle receptor subunit beta"
FT                   /id="PRO_0000331246"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         92..100
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         114..117
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         140
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         268
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   290 AA;  32308 MW;  885A00B6C7060A81 CRC64;
     MKDSAILNQL KVVLPPHIME IIYFRYNQID TYLKPYNLPI KTDVLLLALF TLIFIIIISK
     LFGSSGNKTR SVGGRTSNDK KVKRGVNIAI LGLSNAGKTA LLLNLTNVDK KISTHTSITT
     NNGVYITENK KKLPIIDVPG NGKAKASLPK ILSNSACIIY VIDGTTFIDN STQEAQYLYD
     ILTNESVYQK KIPVLVFNNK MDLDSTIDTE QVKNILEREL DDLRRTRGAT PIVLGQEEDK
     KDIYLGIEGT PFQFDHLPND VQFSNGSASP SNGELKEIDD IKNFIQTTTL