ID   SRPR_PSEPU              Reviewed;         213 AA.
AC   Q9R9T9;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=HTH-type transcriptional regulator SrpR;
DE   AltName: Full=Solvent efflux pump srpABC operon corepressor;
GN   Name=srpR;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700801 / S12;
RA   Dennis J.J., Zylstra G.J.;
RL   Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   CHARACTERIZATION.
RC   STRAIN=ATCC 700801 / S12;
RX   PubMed=11094055; DOI=10.1074/jbc.m007687200;
RA   Wery J., Hidayat B., Kieboom J., de Bont J.A.M.;
RT   "An insertion sequence prepares Pseudomonas putida S12 for severe solvent
RT   stress.";
RL   J. Biol. Chem. 276:5700-5706(2001).
CC   -!- FUNCTION: In conjunction with SrpS represses the srpABC operon.
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DR   EMBL; AF061937; AAF16682.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9R9T9; -.
DR   SMR; Q9R9T9; -.
DR   IntAct; Q9R9T9; 1.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..213
FT                   /note="HTH-type transcriptional regulator SrpR"
FT                   /id="PRO_0000070627"
FT   DOMAIN          10..70
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   213 AA;  23876 MW;  2201B522EC4B1813 CRC64;
     MARKTAAEAE ETRQRIIDAA LEVFVAQGVS DATLDQIARK AGVTRGAVYW HFNGKLEVLQ
     AVLASRQHPL ELDFTPDLGI ERSWEAVVVA MLDAVHSPQS KQFSEILIYQ GLDESGLIHN
     RMVQASDRFL QYIHQVLRHA VTQGELPINL DLQTSIGVFK GLITGLLYEG LRSKDQQAQI
     IKVALGSFWA LLREPPRFLL CEEAQIKQVK SFE