ID   SRPS_PSEPU              Reviewed;         259 AA.
AC   Q9R9U0;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=HTH-type transcriptional regulator SrpS;
DE   AltName: Full=Solvent efflux pump srpABC operon corepressor;
GN   Name=srpS;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700801 / S12;
RA   Dennis J.J., Zylstra G.J.;
RL   Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   CHARACTERIZATION.
RC   STRAIN=ATCC 700801 / S12;
RX   PubMed=11094055; DOI=10.1074/jbc.m007687200;
RA   Wery J., Hidayat B., Kieboom J., de Bont J.A.M.;
RT   "An insertion sequence prepares Pseudomonas putida S12 for severe solvent
RT   stress.";
RL   J. Biol. Chem. 276:5700-5706(2001).
CC   -!- FUNCTION: In conjunction with SrpR represses the srpABC operon.
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DR   EMBL; AF061937; AAF16681.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9R9U0; -.
DR   SMR; Q9R9U0; -.
DR   IntAct; Q9R9U0; 1.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR   InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF09339; HTH_IclR; 1.
DR   Pfam; PF01614; IclR; 1.
DR   SMART; SM00346; HTH_ICLR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51077; HTH_ICLR; 1.
DR   PROSITE; PS51078; ICLR_ED; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..259
FT                   /note="HTH-type transcriptional regulator SrpS"
FT                   /id="PRO_0000201768"
FT   DOMAIN          14..76
FT                   /note="HTH iclR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   DOMAIN          89..253
FT                   /note="IclR-ED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00394"
FT   DNA_BIND        36..59
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
SQ   SEQUENCE   259 AA;  27579 MW;  322E1DF03842C211 CRC64;
     MNQSDENVGK AGGIQVIARA ASIMRALGSH PHGLSLAAIA QLVGLPRSTV QRIINALEEE
     FLVEALGPAG GFRLGPALGQ LINQAQSDIL SLVKPYLRSL AEELEESVCL ASLAGDKIYV
     LDRIVSEREL RVVFPIGINV PAAATAAGKV LLAALPDETL QAALGEQLPV FTSNTLRRKA
     LVKQLSEVRQ SGFASDLDEH IDGVCSFATL LDTYLGYYSL AVVMPSSRAS KQSDLIKKAL
     LQSKQNIERA IGRASKKAP