ID   SRPX2_XENLA             Reviewed;         458 AA.
AC   Q6GP28;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Sushi repeat-containing protein SRPX2;
DE   Flags: Precursor;
GN   Name=srpx2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in angiogenesis, synapse formation, cellular
CC       migration and adhesion. {ECO:0000250}.
CC   -!- SUBUNIT: Forms homooligomers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Cell surface {ECO:0000250}. Synapse {ECO:0000250}.
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DR   EMBL; BC073320; AAH73320.1; -; mRNA.
DR   RefSeq; NP_001085769.1; NM_001092300.1.
DR   AlphaFoldDB; Q6GP28; -.
DR   DNASU; 444196; -.
DR   GeneID; 444196; -.
DR   KEGG; xla:444196; -.
DR   CTD; 444196; -.
DR   Xenbase; XB-GENE-994518; srpx2.L.
DR   OrthoDB; 544541at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 444196; Expressed in lung and 10 other tissues.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0009986; C:cell surface; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0060076; C:excitatory synapse; ISS:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0097060; C:synaptic membrane; ISS:UniProtKB.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; ISS:UniProtKB.
DR   GO; GO:0051965; P:positive regulation of synapse assembly; ISS:UniProtKB.
DR   CDD; cd00033; CCP; 3.
DR   InterPro; IPR025232; DUF4174.
DR   InterPro; IPR003410; HYR_dom.
DR   InterPro; IPR043555; SRPX-like.
DR   InterPro; IPR028768; SRPX2.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   PANTHER; PTHR46343; PTHR46343; 1.
DR   PANTHER; PTHR46343:SF3; PTHR46343:SF3; 1.
DR   Pfam; PF13778; DUF4174; 1.
DR   Pfam; PF02494; HYR; 1.
DR   Pfam; PF00084; Sushi; 3.
DR   SMART; SM00032; CCP; 3.
DR   SUPFAM; SSF57535; SSF57535; 3.
DR   PROSITE; PS50825; HYR; 1.
DR   PROSITE; PS50923; SUSHI; 3.
PE   2: Evidence at transcript level;
KW   Angiogenesis; Cell adhesion; Cytoplasm; Disulfide bond; Reference proteome;
KW   Repeat; Secreted; Signal; Sushi; Synapse.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..458
FT                   /note="Sushi repeat-containing protein SRPX2"
FT                   /id="PRO_0000274527"
FT   DOMAIN          62..112
FT                   /note="Sushi 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DOMAIN          113..171
FT                   /note="Sushi 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DOMAIN          170..254
FT                   /note="HYR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          255..314
FT                   /note="Sushi 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        64..98
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        84..110
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        115..156
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        142..169
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        257..299
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        285..312
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
SQ   SEQUENCE   458 AA;  51454 MW;  0D268F9572EA8261 CRC64;
     MEASITVLLF AFTKVASSLY YEGSGHSDGE IQTNEVYVES RPLGPYRAPR WCYDLHISDG
     EATCYSPLGP RYRSTLGTRC RLSCDQGFKL IGQSSVQCLS SRRWSGNGHC RRIQCHVLPP
     IFYGSYHCSV GVSEGSRCDY SCAPGYMVEG DRSRICMEDG QWSGGEPVCV DLDPPKIQCP
     VSRMKVAEPE KLTARIFWGN PQVKDSADGV ITRVFLRGPE PGSELPEGEH VIRYTAYDRA
     HNRASCKFIV KVQVRRCPDL TPPLHGYLTC SAAGNNYGAT CEYHCEGGYE RQGPAARVCQ
     FSQNWAGTPS TCTPMLINVN VNSAGAFIDQ FFEKQRLLFI SSPSSSDRYY RMQTTALQSS
     GCGLEQRHVL IVELIGESPR EVGRVRNQQL SKELIEELRQ VLRISRSYFN MVLIDKHGVD
     RDRYRQPTAS EDIFLFIDTY LLSPRELSQV ESNKENCD