SRPX_HUMAN
ID SRPX_HUMAN Reviewed; 464 AA.
AC P78539; A8K065; B3KWP8; B4DDB8; B4DQH5; F5H4D7; G3V1L0; Q4VX66; Q99652;
AC Q99913;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 180.
DE RecName: Full=Sushi repeat-containing protein SRPX;
DE Flags: Precursor;
GN Name=SRPX; Synonyms=ETX1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=8634708; DOI=10.1093/hmg/4.12.2339;
RA Meindl A., Carvalho M.R.S., Herrmann K., Lorenz B., Achatz H., Lorenz B.,
RA Apfelstedt-Sylla E., Wittwer B., Ross M., Meitinger T.;
RT "A gene (SRPX) encoding a sushi-repeat-containing protein is deleted in
RT patients with X-linked retinitis pigmentosa.";
RL Hum. Mol. Genet. 4:2339-2346(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, AND VARIANTS
RP LEU-23 DEL; SER-225 AND PHE-413.
RX PubMed=8634709; DOI=10.1093/hmg/4.12.2347;
RA Dry K.L., Aldred M.A., Edgar A.J., Brown J., Manson F.D., Ho M.-F.,
RA Prosser J., Hardwick L.J., Lennon A.A., Thomson K., van Keuren M.,
RA Kurnit D.M., Bird A.C., Jay M., Monaco A.P., Wright A.F.;
RT "Identification of a novel gene, ETX1 from Xp21.1, a candidate gene for X-
RT linked retinitis pigmentosa (RP3).";
RL Hum. Mol. Genet. 4:2347-2353(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT LEU-23 DEL.
RX PubMed=9162095; DOI=10.1007/s002510050247;
RA Nangaku M., Shankland S.J., Kurokawa K., Bomsztyk K., Johnson R.J.,
RA Couser W.G.;
RT "Cloning of a new human gene with short consensus repeats using the EST
RT database.";
RL Immunogenetics 46:99-103(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5), AND
RP VARIANT LEU-23 DEL.
RC TISSUE=Prostate;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: May be involved in phagocytosis during disk shedding, cell
CC adhesion to cells other than the pigment epithelium or signal
CC transduction.
CC -!- INTERACTION:
CC P78539; Q9BRX2: PELO; NbExp=6; IntAct=EBI-2371213, EBI-1043580;
CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000305}. Note=Possibly surface
CC of photoreceptor cell.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Comment=Additional isoforms seem to exist.;
CC Name=1;
CC IsoId=P78539-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P78539-2; Sequence=VSP_004430;
CC Name=3;
CC IsoId=P78539-3; Sequence=VSP_043056;
CC Name=4;
CC IsoId=P78539-4; Sequence=VSP_045468;
CC Name=5;
CC IsoId=P78539-5; Sequence=VSP_046757;
CC -!- TISSUE SPECIFICITY: Retina and heart; less in placenta, pancreas, lung,
CC liver, skeletal muscle, kidney and brain.
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DR EMBL; U78093; AAB36685.1; -; mRNA.
DR EMBL; S82496; AAB37378.1; -; Genomic_DNA.
DR EMBL; S82496; AAB37379.1; -; Genomic_DNA.
DR EMBL; AK125542; BAG54210.1; -; mRNA.
DR EMBL; U61374; AAB40715.1; -; mRNA.
DR EMBL; AK289430; BAF82119.1; -; mRNA.
DR EMBL; AK293127; BAG56679.1; -; mRNA.
DR EMBL; AK298802; BAG60937.1; -; mRNA.
DR EMBL; AL121578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL133494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL606748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL627246; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471141; EAW59447.1; -; Genomic_DNA.
DR EMBL; BC020684; AAH20684.1; -; mRNA.
DR CCDS; CCDS14245.1; -. [P78539-1]
DR CCDS; CCDS55400.1; -. [P78539-5]
DR CCDS; CCDS55401.1; -. [P78539-3]
DR CCDS; CCDS55402.1; -. [P78539-4]
DR RefSeq; NP_001164221.1; NM_001170750.1. [P78539-5]
DR RefSeq; NP_001164222.1; NM_001170751.1. [P78539-3]
DR RefSeq; NP_001164223.1; NM_001170752.1. [P78539-4]
DR RefSeq; NP_006298.1; NM_006307.4. [P78539-1]
DR AlphaFoldDB; P78539; -.
DR BioGRID; 113994; 4.
DR IntAct; P78539; 7.
DR STRING; 9606.ENSP00000367794; -.
DR iPTMnet; P78539; -.
DR PhosphoSitePlus; P78539; -.
DR BioMuta; SRPX; -.
DR DMDM; 2498958; -.
DR EPD; P78539; -.
DR jPOST; P78539; -.
DR MassIVE; P78539; -.
DR PaxDb; P78539; -.
DR PeptideAtlas; P78539; -.
DR PRIDE; P78539; -.
DR ProteomicsDB; 26540; -.
DR ProteomicsDB; 32366; -.
DR ProteomicsDB; 57641; -. [P78539-1]
DR ProteomicsDB; 57642; -. [P78539-2]
DR ProteomicsDB; 57643; -. [P78539-3]
DR Antibodypedia; 640; 232 antibodies from 28 providers.
DR DNASU; 8406; -.
DR Ensembl; ENST00000378533.4; ENSP00000367794.3; ENSG00000101955.15. [P78539-1]
DR Ensembl; ENST00000432886.6; ENSP00000411165.2; ENSG00000101955.15. [P78539-3]
DR Ensembl; ENST00000538295.5; ENSP00000445034.1; ENSG00000101955.15. [P78539-4]
DR Ensembl; ENST00000544439.5; ENSP00000440758.1; ENSG00000101955.15. [P78539-5]
DR GeneID; 8406; -.
DR KEGG; hsa:8406; -.
DR MANE-Select; ENST00000378533.4; ENSP00000367794.3; NM_006307.5; NP_006298.1.
DR UCSC; uc004ddy.3; human. [P78539-1]
DR CTD; 8406; -.
DR DisGeNET; 8406; -.
DR GeneCards; SRPX; -.
DR HGNC; HGNC:11309; SRPX.
DR HPA; ENSG00000101955; Tissue enhanced (adipose).
DR MIM; 300187; gene.
DR neXtProt; NX_P78539; -.
DR OpenTargets; ENSG00000101955; -.
DR PharmGKB; PA36133; -.
DR VEuPathDB; HostDB:ENSG00000101955; -.
DR eggNOG; ENOG502QVU2; Eukaryota.
DR GeneTree; ENSGT00940000160302; -.
DR HOGENOM; CLU_047011_0_0_1; -.
DR InParanoid; P78539; -.
DR OMA; YARNRYK; -.
DR OrthoDB; 544541at2759; -.
DR PhylomeDB; P78539; -.
DR TreeFam; TF336515; -.
DR PathwayCommons; P78539; -.
DR SignaLink; P78539; -.
DR SIGNOR; P78539; -.
DR BioGRID-ORCS; 8406; 13 hits in 700 CRISPR screens.
DR ChiTaRS; SRPX; human.
DR GeneWiki; SRPX; -.
DR GenomeRNAi; 8406; -.
DR Pharos; P78539; Tbio.
DR PRO; PR:P78539; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; P78539; protein.
DR Bgee; ENSG00000101955; Expressed in pericardium and 198 other tissues.
DR Genevisible; P78539; HS.
DR GO; GO:0005776; C:autophagosome; IEA:Ensembl.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; TAS:ProtInc.
DR GO; GO:0006914; P:autophagy; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0060244; P:negative regulation of cell proliferation involved in contact inhibition; IEA:Ensembl.
DR GO; GO:0001845; P:phagolysosome assembly; IBA:GO_Central.
DR GO; GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
DR CDD; cd00033; CCP; 3.
DR InterPro; IPR025232; DUF4174.
DR InterPro; IPR003410; HYR_dom.
DR InterPro; IPR036981; SRPX.
DR InterPro; IPR043555; SRPX-like.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR46343; PTHR46343; 1.
DR PANTHER; PTHR46343:SF1; PTHR46343:SF1; 1.
DR Pfam; PF13778; DUF4174; 1.
DR Pfam; PF02494; HYR; 1.
DR Pfam; PF00084; Sushi; 3.
DR SMART; SM00032; CCP; 3.
DR SUPFAM; SSF57535; SSF57535; 3.
DR PROSITE; PS50825; HYR; 1.
DR PROSITE; PS50923; SUSHI; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell adhesion; Disulfide bond; Reference proteome;
KW Repeat; Signal; Sushi.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..464
FT /note="Sushi repeat-containing protein SRPX"
FT /id="PRO_0000022416"
FT DOMAIN 57..117
FT /note="Sushi 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 118..176
FT /note="Sushi 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 177..259
FT /note="HYR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT DOMAIN 260..319
FT /note="Sushi 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 57..85
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 69..103
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 89..115
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 120..161
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 147..174
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 262..304
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 290..317
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT VAR_SEQ 1..52
FT /note="MGSPAHRPALLLLLPPLLLLLLLRVPPSRSFPGSGDSPLEDDEVGYSHPRYK
FT -> MDFDVGRTTHLSSSPCSASNGGESGQVSKRRCLIGESGH (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_004430"
FT VAR_SEQ 33..52
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_046757"
FT VAR_SEQ 117..176
FT /note="QKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWS
FT GRPASCVD -> H (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043056"
FT VAR_SEQ 364..464
FT /note="QAQCGLDLRHITVVELVGVFPTLIGRIGAKIMPPALALQLRLLLRIPLYSFS
FT MVLVDKHGMDKERYVSLVMPVALFNLIDTFPLRKEEMVLQAEMSQTCNT -> AVAANP
FT TLLLQYGASG (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045468"
FT VARIANT 23
FT /note="Missing"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:8634709, ECO:0000269|PubMed:9162095"
FT /id="VAR_005624"
FT VARIANT 225
FT /note="P -> S (in dbSNP:rs1123773)"
FT /evidence="ECO:0000269|PubMed:8634709"
FT /id="VAR_005625"
FT VARIANT 413
FT /note="S -> F (in dbSNP:rs35318931)"
FT /evidence="ECO:0000269|PubMed:8634709"
FT /id="VAR_005626"
FT CONFLICT 170..178
FT /note="RPASCVDME -> ASLLCGYG (in Ref. 3; AAB40715)"
FT /evidence="ECO:0000305"
FT CONFLICT 202
FT /note="Missing (in Ref. 3; AAB40715)"
FT /evidence="ECO:0000305"
FT CONFLICT 242
FT /note="Y -> H (in Ref. 4; BAG54210)"
FT /evidence="ECO:0000305"
FT CONFLICT 292
FT /note="G -> S (in Ref. 4; BAF82119)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 464 AA; 51572 MW; 9CD5E57BC2848680 CRC64;
MGSPAHRPAL LLLLPPLLLL LLLRVPPSRS FPGSGDSPLE DDEVGYSHPR YKDTPWCSPI
KVKYGDVYCR APQGGYYKTA LGTRCDIRCQ KGYELHGSSL LICQSNKRWS DKVICKQKRC
PTLAMPANGG FKCVDGAYFN SRCEYYCSPG YTLKGERTVT CMDNKAWSGR PASCVDMEPP
RIKCPSVKER IAEPNKLTVR VSWETPEGRD TADGILTDVI LKGLPPGSNF PEGDHKIQYT
VYDRAENKGT CKFRVKVRVK RCGKLNAPEN GYMKCSSDGD NYGATCEFSC IGGYELQGSP
ARVCQSNLAW SGTEPTCAAM NVNVGVRTAA ALLDQFYEKR RLLIVSTPTA RNLLYRLQLG
MLQQAQCGLD LRHITVVELV GVFPTLIGRI GAKIMPPALA LQLRLLLRIP LYSFSMVLVD
KHGMDKERYV SLVMPVALFN LIDTFPLRKE EMVLQAEMSQ TCNT
