SRPX_MOUSE
ID SRPX_MOUSE Reviewed; 464 AA.
AC Q9R0M3; A2BE46; A2BE47; Q9R0M2;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Sushi-repeat-containing protein SRPX;
DE AltName: Full=DRS protein;
DE Flags: Precursor;
GN Name=Srpx;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Ovary;
RA Inoue H.;
RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=Drs-1;
CC IsoId=Q9R0M3-1; Sequence=Displayed;
CC Name=2; Synonyms=Drs-2;
CC IsoId=Q9R0M3-2; Sequence=VSP_014016;
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DR EMBL; AB028049; BAA87328.1; -; mRNA.
DR EMBL; AB028050; BAA87329.1; -; mRNA.
DR EMBL; AK034696; BAC28800.1; -; mRNA.
DR EMBL; BX005236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC022572; AAH22572.1; -; mRNA.
DR CCDS; CCDS30013.1; -. [Q9R0M3-1]
DR CCDS; CCDS90696.1; -. [Q9R0M3-2]
DR RefSeq; NP_058607.1; NM_016911.4. [Q9R0M3-1]
DR AlphaFoldDB; Q9R0M3; -.
DR SMR; Q9R0M3; -.
DR STRING; 10090.ENSMUSP00000047926; -.
DR PhosphoSitePlus; Q9R0M3; -.
DR MaxQB; Q9R0M3; -.
DR PaxDb; Q9R0M3; -.
DR PRIDE; Q9R0M3; -.
DR ProteomicsDB; 263348; -. [Q9R0M3-1]
DR ProteomicsDB; 263349; -. [Q9R0M3-2]
DR Antibodypedia; 640; 232 antibodies from 28 providers.
DR DNASU; 51795; -.
DR Ensembl; ENSMUST00000044789; ENSMUSP00000047926; ENSMUSG00000090084. [Q9R0M3-1]
DR Ensembl; ENSMUST00000115543; ENSMUSP00000111205; ENSMUSG00000090084. [Q9R0M3-2]
DR GeneID; 51795; -.
DR KEGG; mmu:51795; -.
DR UCSC; uc009sqc.1; mouse. [Q9R0M3-1]
DR UCSC; uc012het.1; mouse. [Q9R0M3-2]
DR CTD; 8406; -.
DR MGI; MGI:1858306; Srpx.
DR VEuPathDB; HostDB:ENSMUSG00000090084; -.
DR eggNOG; ENOG502QVU2; Eukaryota.
DR GeneTree; ENSGT00940000160302; -.
DR HOGENOM; CLU_047011_0_0_1; -.
DR InParanoid; Q9R0M3; -.
DR OMA; YARNRYK; -.
DR OrthoDB; 544541at2759; -.
DR PhylomeDB; Q9R0M3; -.
DR TreeFam; TF336515; -.
DR BioGRID-ORCS; 51795; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Srpx; mouse.
DR PRO; PR:Q9R0M3; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9R0M3; protein.
DR Bgee; ENSMUSG00000090084; Expressed in vault of skull and 120 other tissues.
DR ExpressionAtlas; Q9R0M3; baseline and differential.
DR Genevisible; Q9R0M3; MM.
DR GO; GO:0005776; C:autophagosome; IDA:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI.
DR GO; GO:0006914; P:autophagy; IMP:MGI.
DR GO; GO:0060244; P:negative regulation of cell proliferation involved in contact inhibition; IDA:MGI.
DR GO; GO:0001845; P:phagolysosome assembly; IMP:MGI.
DR GO; GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IMP:MGI.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IMP:MGI.
DR CDD; cd00033; CCP; 3.
DR InterPro; IPR025232; DUF4174.
DR InterPro; IPR003410; HYR_dom.
DR InterPro; IPR036981; SRPX.
DR InterPro; IPR043555; SRPX-like.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR46343; PTHR46343; 1.
DR PANTHER; PTHR46343:SF1; PTHR46343:SF1; 1.
DR Pfam; PF13778; DUF4174; 1.
DR Pfam; PF02494; HYR; 1.
DR Pfam; PF00084; Sushi; 3.
DR SMART; SM00032; CCP; 3.
DR SUPFAM; SSF57535; SSF57535; 3.
DR PROSITE; PS50825; HYR; 1.
DR PROSITE; PS50923; SUSHI; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Reference proteome; Repeat; Signal;
KW Sushi.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..464
FT /note="Sushi-repeat-containing protein SRPX"
FT /id="PRO_0000022417"
FT DOMAIN 57..117
FT /note="Sushi 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 118..176
FT /note="Sushi 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 177..259
FT /note="HYR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT DOMAIN 260..319
FT /note="Sushi 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 57..85
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 69..103
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 89..115
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 120..161
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 147..174
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 262..304
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 290..317
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT VAR_SEQ 33..117
FT /note="GSGDSPLEDDGVWYSHSLYKDTPWCSPIKVKYGDVYCRAPPGGYYKTALGTR
FT CDIRCRKGYELHGSSQLICQSNKRWSDKVICKQ -> E (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_014016"
SQ SEQUENCE 464 AA; 51574 MW; 978C5B8F896B4333 CRC64;
MGSPGLRPEL LLPQVLPLLL ALLHVLPSQG FPGSGDSPLE DDGVWYSHSL YKDTPWCSPI
KVKYGDVYCR APPGGYYKTA LGTRCDIRCR KGYELHGSSQ LICQSNKRWS DKVICKQKRC
PTLTMPANGG FKCVDGAYFN SRCEYYCSPG YTLKGERTVT CMDNKAWSGR PASCVDLEPP
RIKCPSVKER IAEPNKLTVR VSWESPEGRD TADGILTDVI LKGLPPGSNF PEGDHKIEYT
VYDRAENKGT CKFRVKVRVR RCGKLNAPEN GYMKCSSDGD NYGATCEFSC IGGYELQGSP
ARVCQSNLAW SGTEPSCAAM NVNVGVRTAA ALLDQFYEKR RLLIVSTPTA RNLLYRLQLG
MLQQAQCGLD LRHVTVVELV GVFPTLIGRI RAKIMPPALA LQLRLLLRIP LYSFSMVVVD
KHGMDKERYV SLVTPMALFN LIDTFPLRKE EMILQAEMGQ TCNV
