SRPX_RAT
ID SRPX_RAT Reviewed; 464 AA.
AC Q63769; Q5PPK5;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Sushi repeat-containing protein SRPX;
DE AltName: Full=Down-regulated by v-SRC;
DE Short=DRS;
DE Flags: Precursor;
GN Name=Srpx; Synonyms=Drs;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=Fischer; TISSUE=Embryonic fibroblast;
RX PubMed=8612783; DOI=10.1016/0014-5793(96)00210-4;
RA Pan J., Nakanishi K., Yutsudo M., Inoue H., Li Q., Oka K., Yoshioka N.,
RA Hakura A.;
RT "Isolation of a novel gene down-regulated by v-src.";
RL FEBS Lett. 383:21-25(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q63769-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q63769-2; Sequence=VSP_014017;
CC -!- TISSUE SPECIFICITY: Normal cells and cells transformed by human
CC papillomavirus type 16 E6E7 and polyomavirus large T. Suppressed in
CC cells transformed by oncogenes such as V-SRC, V-ABL, V-FPS, V-MOS, V-
CC SIS, V-K-RAS, and polyomavirus middle T.
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DR EMBL; D78359; BAA11371.1; -; mRNA.
DR EMBL; BC087639; AAH87639.1; -; mRNA.
DR RefSeq; NP_071969.1; NM_022524.1. [Q63769-1]
DR RefSeq; XP_006256745.1; XM_006256683.3. [Q63769-2]
DR AlphaFoldDB; Q63769; -.
DR STRING; 10116.ENSRNOP00000048924; -.
DR PaxDb; Q63769; -.
DR PRIDE; Q63769; -.
DR Ensembl; ENSRNOT00000045753; ENSRNOP00000048924; ENSRNOG00000003013. [Q63769-1]
DR Ensembl; ENSRNOT00000114608; ENSRNOP00000083955; ENSRNOG00000003013. [Q63769-2]
DR GeneID; 64316; -.
DR KEGG; rno:64316; -.
DR UCSC; RGD:70950; rat. [Q63769-1]
DR CTD; 8406; -.
DR RGD; 70950; Srpx.
DR eggNOG; ENOG502QVU2; Eukaryota.
DR GeneTree; ENSGT00940000159616; -.
DR HOGENOM; CLU_047011_0_0_1; -.
DR InParanoid; Q63769; -.
DR OMA; YARNRYK; -.
DR OrthoDB; 544541at2759; -.
DR PhylomeDB; Q63769; -.
DR TreeFam; TF336515; -.
DR PRO; PR:Q63769; -.
DR Proteomes; UP000002494; Chromosome X.
DR Bgee; ENSRNOG00000039666; Expressed in esophagus and 18 other tissues.
DR Genevisible; Q63769; RN.
DR GO; GO:0005776; C:autophagosome; ISO:RGD.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:RGD.
DR GO; GO:0006914; P:autophagy; ISO:RGD.
DR GO; GO:0060244; P:negative regulation of cell proliferation involved in contact inhibition; ISO:RGD.
DR GO; GO:0001845; P:phagolysosome assembly; ISO:RGD.
DR GO; GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; ISO:RGD.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; ISO:RGD.
DR CDD; cd00033; CCP; 3.
DR InterPro; IPR025232; DUF4174.
DR InterPro; IPR003410; HYR_dom.
DR InterPro; IPR036981; SRPX.
DR InterPro; IPR043555; SRPX-like.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR46343; PTHR46343; 1.
DR PANTHER; PTHR46343:SF1; PTHR46343:SF1; 1.
DR Pfam; PF13778; DUF4174; 1.
DR Pfam; PF02494; HYR; 1.
DR Pfam; PF00084; Sushi; 3.
DR SMART; SM00032; CCP; 3.
DR SUPFAM; SSF57535; SSF57535; 3.
DR PROSITE; PS50825; HYR; 1.
DR PROSITE; PS50923; SUSHI; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Reference proteome; Repeat; Signal;
KW Sushi.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..464
FT /note="Sushi repeat-containing protein SRPX"
FT /id="PRO_0000022418"
FT DOMAIN 57..117
FT /note="Sushi 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 118..176
FT /note="Sushi 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 177..259
FT /note="HYR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT DOMAIN 260..319
FT /note="Sushi 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 57..85
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 69..103
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 89..115
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 120..161
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 147..174
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 262..304
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 290..317
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT VAR_SEQ 33..52
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_014017"
SQ SEQUENCE 464 AA; 51560 MW; B27C5B163090A97E CRC64;
MGSPGLRPTL LLPQVLLLLL ALLHVPPSQG FPGSGDSPLE DDGVWSSHSL YKDTPWCSPI
KVKYGDVYCR APPGGYYKTA LGTRCDIRCR KGYELHGSSQ LVCQSNRRWS DKVICKQKRC
PTLTMPANGG FKCVDGAYFN SRCEYYCSPG YTLKGERTVT CMDNKAWSGR PASCVDMEPP
RIKCPSVKER IAEPNKLTVR VSWETPEGRD TADGILTDVI LRGLPPGSNF PEGDHKIEYT
VYDRAENKGT CKFRVKVRVR RCGKLNAPEN GYMKCSSDGD NYGATCEFSC IGGYELQGSP
ARVCQSNLAW SGTEPSCAAM NVNVGVRTAA ALLDQFYEKR RLLIVSTPTA RNLLYRLQLG
MLQQAQCGLD LRHITVVELV GVFPTLIGRI RAKIMPPALA LQLRLLLRIP LYSFSMVLVD
KHGMDKERYV SLVTPMALFN LIDTFPLRKE EMILQAEMGQ SCNT
