SRP_DROME
ID SRP_DROME Reviewed; 1264 AA.
AC P52172; Q6NMW1; Q7K0H5; Q8INC6; Q94884; Q9VF01;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 182.
DE RecName: Full=Box A-binding factor;
DE Short=ABF;
DE AltName: Full=GATA-binding factor B;
DE AltName: Full=Protein serpent;
DE AltName: Full=Transcription factor GATA-B;
DE AltName: Full=dGATA-B;
GN Name=srp; Synonyms=ABF; ORFNames=CG3992;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 127-1264 (ISOFORM 1).
RX PubMed=9012522; DOI=10.1242/dev.122.12.4023;
RA Rehorn K.-P., Thelen H., Michelson A.M., Reuter R.;
RT "A molecular aspect of hematopoiesis and endoderm development common to
RT vertebrates and Drosophila.";
RL Development 122:4023-4031(1996).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 271-1264 (ISOFORM 1).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 377-1264.
RX PubMed=8187633; DOI=10.1242/dev.119.3.623;
RA Abel T., Michelson A.M., Maniatis T.;
RT "A Drosophila GATA family member that binds to Adh regulatory sequences is
RT expressed in the developing fat body.";
RL Development 119:623-633(1993).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1208 AND SER-1210, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: May function as a transcriptional activator protein and may
CC play a key role in the organogenesis of the fat body. Binds a sequence
CC element (5'-[TA]GATAA-3') found in the larval promoters of all known
CC alcohol dehydrogenase (ADH) genes. Acts as a homeotic gene downstream
CC of the terminal gap gene HKB to promote morphogenesis and
CC differentiation of anterior and posterior midgut.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=A;
CC IsoId=P52172-1; Sequence=Displayed;
CC Name=2; Synonyms=B;
CC IsoId=P52172-2; Sequence=VSP_015187;
CC Name=3;
CC IsoId=P52172-3; Sequence=VSP_015186;
CC -!- DEVELOPMENTAL STAGE: Initially observed in the analgen of the anterior
CC and posterior midgut and the cephalic mesoderm. It is found in both the
CC endodermal and mesodermal germ layers and for a brief period during
CC gastrulation it is expressed in the amnioserosa. During germ band
CC retraction it becomes restricted to the fat body.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL39968.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAA53807.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAA68943.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AE014297; AAF55261.2; -; Genomic_DNA.
DR EMBL; AE014297; AAN13691.1; -; Genomic_DNA.
DR EMBL; BT011543; AAS15679.1; -; mRNA.
DR EMBL; Y07662; CAA68943.1; ALT_FRAME; mRNA.
DR EMBL; AY069823; AAL39968.1; ALT_INIT; mRNA.
DR EMBL; X76217; CAA53807.1; ALT_FRAME; mRNA.
DR PIR; S40382; S40382.
DR RefSeq; NP_001027190.1; NM_001032019.3. [P52172-3]
DR RefSeq; NP_001262618.1; NM_001275689.1. [P52172-3]
DR RefSeq; NP_732098.1; NM_169694.3. [P52172-2]
DR RefSeq; NP_732100.2; NM_169696.3. [P52172-1]
DR AlphaFoldDB; P52172; -.
DR SMR; P52172; -.
DR BioGRID; 66998; 23.
DR IntAct; P52172; 1.
DR STRING; 7227.FBpp0082669; -.
DR iPTMnet; P52172; -.
DR PaxDb; P52172; -.
DR DNASU; 41944; -.
DR EnsemblMetazoa; FBtr0083215; FBpp0082669; FBgn0003507. [P52172-1]
DR EnsemblMetazoa; FBtr0083216; FBpp0082670; FBgn0003507. [P52172-2]
DR EnsemblMetazoa; FBtr0100595; FBpp0100052; FBgn0003507. [P52172-3]
DR EnsemblMetazoa; FBtr0335423; FBpp0307406; FBgn0003507. [P52172-3]
DR GeneID; 41944; -.
DR KEGG; dme:Dmel_CG3992; -.
DR CTD; 41944; -.
DR FlyBase; FBgn0003507; srp.
DR VEuPathDB; VectorBase:FBgn0003507; -.
DR eggNOG; KOG1601; Eukaryota.
DR GeneTree; ENSGT00940000169284; -.
DR InParanoid; P52172; -.
DR OMA; ASTDPIM; -.
DR PhylomeDB; P52172; -.
DR Reactome; R-DME-5689880; Ub-specific processing proteases.
DR Reactome; R-DME-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR Reactome; R-DME-9018519; Estrogen-dependent gene expression.
DR Reactome; R-DME-983231; Factors involved in megakaryocyte development and platelet production.
DR SignaLink; P52172; -.
DR BioGRID-ORCS; 41944; 2 hits in 3 CRISPR screens.
DR ChiTaRS; srp; fly.
DR GenomeRNAi; 41944; -.
DR PRO; PR:P52172; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0003507; Expressed in spermathecum and 58 other tissues.
DR ExpressionAtlas; P52172; baseline and differential.
DR Genevisible; P52172; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IPI:FlyBase.
DR GO; GO:0003677; F:DNA binding; IDA:FlyBase.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:FlyBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:FlyBase.
DR GO; GO:0001223; F:transcription coactivator binding; IPI:FlyBase.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0046665; P:amnioserosa maintenance; IMP:FlyBase.
DR GO; GO:0006914; P:autophagy; IMP:FlyBase.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0042688; P:crystal cell differentiation; TAS:FlyBase.
DR GO; GO:0007391; P:dorsal closure; TAS:FlyBase.
DR GO; GO:0035050; P:embryonic heart tube development; IMP:FlyBase.
DR GO; GO:0035162; P:embryonic hemopoiesis; IMP:FlyBase.
DR GO; GO:0007492; P:endoderm development; TAS:FlyBase.
DR GO; GO:0001706; P:endoderm formation; TAS:FlyBase.
DR GO; GO:0007503; P:fat body development; IEP:FlyBase.
DR GO; GO:0008354; P:germ cell migration; IMP:FlyBase.
DR GO; GO:0007390; P:germ-band shortening; IMP:FlyBase.
DR GO; GO:0007516; P:hemocyte development; IMP:FlyBase.
DR GO; GO:0030097; P:hemopoiesis; IMP:FlyBase.
DR GO; GO:0035167; P:larval lymph gland hemopoiesis; IMP:FlyBase.
DR GO; GO:0048542; P:lymph gland development; IMP:FlyBase.
DR GO; GO:0001710; P:mesodermal cell fate commitment; IMP:FlyBase.
DR GO; GO:0007494; P:midgut development; TAS:FlyBase.
DR GO; GO:0042690; P:negative regulation of crystal cell differentiation; TAS:FlyBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:2000427; P:positive regulation of apoptotic cell clearance; IMP:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:FlyBase.
DR GO; GO:0007435; P:salivary gland morphogenesis; IMP:FlyBase.
DR CDD; cd00202; ZnF_GATA; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR039355; Transcription_factor_GATA.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR10071; PTHR10071; 1.
DR Pfam; PF00320; GATA; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 1.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; Developmental protein; DNA-binding;
KW Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..1264
FT /note="Box A-binding factor"
FT /id="PRO_0000083461"
FT ZN_FING 803..827
FT /note="GATA-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1181..1202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..860
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..1048
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1208
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1210
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT VAR_SEQ 1..518
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_015186"
FT VAR_SEQ 721..790
FT /note="MAAESGGDFYKPNSFNVGGGGRSKANTSGAASSYSCPGSNATSAATSAVASG
FT TAATAATTLDEHVSRANS -> TLFDADYFTEGRECVNCGAISTPLWRRDNTGHYLCNA
FT CGLYMKMNGMNRPLIKQP (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_015187"
FT CONFLICT 138
FT /note="V -> A (in Ref. 4; CAA68943)"
FT /evidence="ECO:0000305"
FT CONFLICT 161
FT /note="T -> P (in Ref. 4; CAA68943)"
FT /evidence="ECO:0000305"
FT CONFLICT 181
FT /note="N -> I (in Ref. 4; CAA68943)"
FT /evidence="ECO:0000305"
FT CONFLICT 274
FT /note="A -> T (in Ref. 4; CAA68943)"
FT /evidence="ECO:0000305"
FT CONFLICT 278
FT /note="A -> T (in Ref. 4; CAA68943)"
FT /evidence="ECO:0000305"
FT CONFLICT 282
FT /note="A -> T (in Ref. 4; CAA68943)"
FT /evidence="ECO:0000305"
FT CONFLICT 346
FT /note="A -> T (in Ref. 4; CAA68943)"
FT /evidence="ECO:0000305"
FT CONFLICT 412..413
FT /note="HH -> QQHQ (in Ref. 6; CAA53807)"
FT /evidence="ECO:0000305"
FT CONFLICT 931
FT /note="L -> V (in Ref. 4; CAA68943 and 6; CAA53807)"
FT /evidence="ECO:0000305"
FT CONFLICT 1031..1035
FT /note="NSSIF -> SSLFN (in Ref. 4; CAA68943 and 6;
FT CAA53807)"
FT /evidence="ECO:0000305"
FT CONFLICT 1069
FT /note="G -> D (in Ref. 4; CAA68943 and 6; CAA53807)"
FT /evidence="ECO:0000305"
FT CONFLICT 1230..1231
FT /note="LQ -> PE (in Ref. 4; CAA68943 and 6; CAA53807)"
FT /evidence="ECO:0000305"
FT CONFLICT 1236
FT /note="A -> S (in Ref. 4; CAA68943 and 6; CAA53807)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1264 AA; 134158 MW; 3E337C34555B23C2 CRC64;
MTKTTKPKEK AAAGGAVIGS GSGLGSVTKA GGGSLLSNAA DSKIRTAKSN NNKRQAGRAA
TALAATTTAS ALAATTTAGA TGSNAAANET EIAIETENGE AATPTAAATA AAANLSSLES
ARSQALTSVV SETARQAVTT ANASATSTST VTAATEIATA TASDTAATSE AAIDDDPSAI
NTNNNNNNSK AQNDASESVK TKVISYHQSE DQQQQQQQQA QIYEQQQQFL SQQLISHHQQ
EQHQQAQQQQ HQQVVQEQHQ ASWLAYDLTS GSAAAAAAAA AAASHPHLFG QFSYPPSHHT
PTQLYEHYPS TDPIMRNNFA FYSVYTGGGG GVGVGMTSHE HLAAAAAAAA AVAQGTTPNI
DEVIQDTLKD ECFEDGHSTD YHVLTSVSDM HTLKDSSPYA LTHEQLHQQQ HHHQQQLHHH
QQQQQQLYHQ QQQQQQQQQH HHHHNNSTSS AGGDSPSSSH ALSTLQSFTQ LTSATQRDSL
SPENDAYFAA AQLGSSLQNS SVYAGSLLTQ TANGIQYGMQ SPNQTQAHLQ QQHHQQQQQQ
HQQHQQQQLQ QQQQQHHHNQ HQHHNSSSSS PGPAGLHHSS SSAATAAAVA AATAAVNGHN
SSLEDGYGSP RSSHSGGGGG GTLPAFQRIA YPNSGSVERY APITNYRGQN DTWFDPLSYA
TSSSGQAQLG VGVGAGVVSN VIRNGRAISA ANAAAAAAAD GTTGRVDPGT FLSASASLSA
MAAESGGDFY KPNSFNVGGG GRSKANTSGA ASSYSCPGSN ATSAATSAVA SGTAATAATT
LDEHVSRANS RRLSASKRAG LSCSNCHTTH TSLWRRNPAG EPVCNACGLY YKLHSVPRPL
TMKKDTIQKR KRKPKGTKSE KSKSKSKNAL NAIMESGSLV TNCHNVGVVL DSSQMDVNDD
MKPQLDLKPY NSYSSQPQQQ LPQYQQQQQL LMADQHSSAA SSPHSMGSTS LSPSAMSHQH
QTHPHQQQQQ QLCSGLDMSP NSNYQMSPLN MQQHQQQQSC SMQHSPSTPT SIFNTPSPTH
QLHNNNNNNN NSSIFNNNNN NNSSSNENNN KLIQKYLQAQ QLSSSSNSGS TSDHQLLAQL
LPNSITAAAA AAAAAAAAAI KTEALSLTSQ ANCSTASAGL MVTSTPTTAS STLSSLSHSN
IISLQNPYHQ AGMTLCKPTR PSPPYYLTPE EDEQPALIKM EEMDQSQQQQ QQQQHQQQQH
GEIMLSRSAS LDEHYELAAF QRHQQQQQQL QQQTAALLGQ HEQHVTNYAM HKFGVDRETV
VKME
