SRR1L_HUMAN
ID SRR1L_HUMAN Reviewed; 339 AA.
AC Q9UH36; Q6NXP8;
DT 30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=SRR1-like protein;
DE AltName: Full=SRR1 domain-containing protein;
GN Name=SRRD; Synonyms=SRR1L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS 44-ARG--GLY-50 DEL AND
RP THR-99.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP INDUCTION.
RX PubMed=28802827; DOI=10.1016/j.abb.2017.08.006;
RA Adachi Y., Umeda M., Kawazoe A., Sato T., Ohkawa Y., Kitajima S., Izawa S.,
RA Sagami I., Taketani S.;
RT "The novel heme-dependent inducible protein, SRRD regulates heme
RT biosynthesis and circadian rhythms.";
RL Arch. Biochem. Biophys. 631:19-29(2017).
CC -!- FUNCTION: Plays a role in the regulation of heme biosynthesis and in
CC the regulation of the expression of core clock genes.
CC {ECO:0000250|UniProtKB:Q8K2M3}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8K2M3}.
CC Note=Also found in intracellular organelles.
CC {ECO:0000250|UniProtKB:Q8K2M3}.
CC -!- INDUCTION: Up-regulated by hemin and 5-aminolevulinic acid.
CC {ECO:0000269|PubMed:28802827}.
CC -!- SIMILARITY: Belongs to the SRR1 family. {ECO:0000305}.
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DR EMBL; Z99714; CAB62929.1; -; Genomic_DNA.
DR EMBL; BC066962; AAH66962.1; -; mRNA.
DR CCDS; CCDS42995.1; -.
DR RefSeq; NP_001013716.2; NM_001013694.2.
DR AlphaFoldDB; Q9UH36; -.
DR SMR; Q9UH36; -.
DR BioGRID; 135310; 3.
DR IntAct; Q9UH36; 1.
DR STRING; 9606.ENSP00000215917; -.
DR iPTMnet; Q9UH36; -.
DR PhosphoSitePlus; Q9UH36; -.
DR BioMuta; SRRD; -.
DR DMDM; 31340433; -.
DR MassIVE; Q9UH36; -.
DR MaxQB; Q9UH36; -.
DR PaxDb; Q9UH36; -.
DR PeptideAtlas; Q9UH36; -.
DR PRIDE; Q9UH36; -.
DR ProteomicsDB; 84276; -.
DR Antibodypedia; 287; 81 antibodies from 18 providers.
DR DNASU; 402055; -.
DR Ensembl; ENST00000215917.11; ENSP00000215917.6; ENSG00000100104.13.
DR GeneID; 402055; -.
DR KEGG; hsa:402055; -.
DR MANE-Select; ENST00000215917.11; ENSP00000215917.6; NM_001013694.3; NP_001013716.2.
DR UCSC; uc010gve.4; human.
DR CTD; 402055; -.
DR GeneCards; SRRD; -.
DR HGNC; HGNC:33910; SRRD.
DR HPA; ENSG00000100104; Low tissue specificity.
DR neXtProt; NX_Q9UH36; -.
DR OpenTargets; ENSG00000100104; -.
DR PharmGKB; PA162404806; -.
DR VEuPathDB; HostDB:ENSG00000100104; -.
DR eggNOG; KOG3131; Eukaryota.
DR GeneTree; ENSGT00390000003948; -.
DR HOGENOM; CLU_062516_0_0_1; -.
DR InParanoid; Q9UH36; -.
DR OMA; WKCVCYG; -.
DR OrthoDB; 1590454at2759; -.
DR PhylomeDB; Q9UH36; -.
DR TreeFam; TF323595; -.
DR PathwayCommons; Q9UH36; -.
DR SignaLink; Q9UH36; -.
DR BioGRID-ORCS; 402055; 71 hits in 1086 CRISPR screens.
DR ChiTaRS; SRRD; human.
DR GenomeRNAi; 402055; -.
DR Pharos; Q9UH36; Tbio.
DR PRO; PR:Q9UH36; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9UH36; protein.
DR Bgee; ENSG00000100104; Expressed in gastrocnemius and 190 other tissues.
DR Genevisible; Q9UH36; HS.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0007017; P:microtubule-based process; IBA:GO_Central.
DR GO; GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB.
DR GO; GO:0070453; P:regulation of heme biosynthetic process; ISS:UniProtKB.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR InterPro; IPR012942; SRR1-like.
DR InterPro; IPR040044; SRR1L.
DR PANTHER; PTHR28626; PTHR28626; 1.
DR Pfam; PF07985; SRR1; 1.
PE 2: Evidence at transcript level;
KW Biological rhythms; Cytoplasm; Heme biosynthesis; Reference proteome;
KW Repeat.
FT CHAIN 1..339
FT /note="SRR1-like protein"
FT /id="PRO_0000186123"
FT REPEAT 30..36
FT /note="1"
FT REPEAT 37..43
FT /note="2"
FT REPEAT 44..50
FT /note="3"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 30..50
FT /note="3 X 7 AA tandem repeats of R-E-A-A-P-R-G"
FT COMPBIAS 29..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 44..50
FT /note="Missing"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_031211"
FT VARIANT 99
FT /note="A -> T (in dbSNP:rs4820682)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_052064"
FT CONFLICT 55
FT /note="F -> L (in Ref. 2; AAH66962)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 339 AA; 38573 MW; 9DDF4C81ED940468 CRC64;
MAAAAAAALE SWQAAAPRKR RSAARRPRRR EAAPRGREAA PRGREAAPRG PEAEFESDSG
VVLRRIWEAE KDLFISDFWS SALETINRCL TKHLEQLKAP VGTLSDIFGN LHLDSLPEES
DVATDSIPRE ILVTGTCHLK CVCYGIGNFA TCIVARNQLT FLLLLLEKCQ IPRSHCWVYD
PLFSQLEIEV LNTLGVTVLS ENEEGKRSIR GEPTIFYMLH CGTALYNNLL WSNWSVDALS
KMVIIGNSFK GLEERLLARI LQKNYPYIAK ILKGLEELEF PQTSQYMDIF NDTSVHWFPV
QKLEQLSIDI WEFREEPDYQ DCEDLEIIRN KREDPSATD
