ID   SRR1L_YEAST             Reviewed;         274 AA.
AC   Q06688; D6VZ48;
DT   30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=SRR1-like protein BER1;
DE   AltName: Full=Benomyl resistant protein 1;
GN   Name=BER1; OrderedLocusNames=YLR412W; ORFNames=L9931.5;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169871;
RA   Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA   Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA   Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA   Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA   Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA   Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA   Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA   Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA   Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA   Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA   Zollner A., Hani J., Hoheisel J.D.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL   Nature 387:87-90(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [5]
RP   FUNCTION.
RX   PubMed=18064466; DOI=10.1007/s00294-007-0169-3;
RA   Fiechter V., Cameroni E., Cerutti L., De Virgilio C., Barral Y.,
RA   Fankhauser C.;
RT   "The evolutionary conserved BER1 gene is involved in microtubule stability
RT   in yeast.";
RL   Curr. Genet. 53:107-115(2008).
CC   -!- FUNCTION: Involved in microtubule stability and kinetochore function.
CC       May be involved in protein N-terminus acetylation and/or proteasome
CC       biogenesis. {ECO:0000269|PubMed:18064466}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000269|PubMed:14562095}.
CC   -!- MISCELLANEOUS: Present with 6490 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the SRR1 family. {ECO:0000305}.
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DR   EMBL; U20162; AAB67495.1; -; Genomic_DNA.
DR   EMBL; BK006945; DAA09714.1; -; Genomic_DNA.
DR   PIR; S59378; S59378.
DR   RefSeq; NP_013516.1; NM_001182300.1.
DR   AlphaFoldDB; Q06688; -.
DR   BioGRID; 31671; 141.
DR   DIP; DIP-4239N; -.
DR   STRING; 4932.YLR412W; -.
DR   iPTMnet; Q06688; -.
DR   MaxQB; Q06688; -.
DR   PaxDb; Q06688; -.
DR   PRIDE; Q06688; -.
DR   EnsemblFungi; YLR412W_mRNA; YLR412W; YLR412W.
DR   GeneID; 851130; -.
DR   KEGG; sce:YLR412W; -.
DR   SGD; S000004404; BER1.
DR   VEuPathDB; FungiDB:YLR412W; -.
DR   eggNOG; KOG3131; Eukaryota.
DR   HOGENOM; CLU_084828_0_0_1; -.
DR   InParanoid; Q06688; -.
DR   OMA; NDIVSHT; -.
DR   BioCyc; YEAST:G3O-32474-MON; -.
DR   PRO; PR:Q06688; -.
DR   Proteomes; UP000002311; Chromosome XII.
DR   RNAct; Q06688; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0007017; P:microtubule-based process; IMP:SGD.
DR   InterPro; IPR012942; SRR1-like.
DR   InterPro; IPR040044; SRR1L.
DR   PANTHER; PTHR28626; PTHR28626; 1.
DR   Pfam; PF07985; SRR1; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Cytoskeleton; Microtubule; Reference proteome.
FT   CHAIN           1..274
FT                   /note="SRR1-like protein BER1"
FT                   /id="PRO_0000186127"
SQ   SEQUENCE   274 AA;  31707 MW;  1B9FBC82F970946A CRC64;
     MDFKASGTKF KKTGKKVVPA KAFEEIVQTN RDVLKKSAFL SDLLENLQPH LNNIKKIRCV
     AIGNFKEDFP ATYQFALLLE ITDYIKSEDE RDVVVSLYDP IFTKEEIQYL KSLGSKWLIE
     EEFSENDAID YESVLYFLPH APLDLTENIL SSQRPHLWLA NNMISHTDRY TKAKLCENYP
     NLSKLVHYLQ TNAPPEVKKA HDVDGFATFI PKRKRKNRNN SSKLKVTPSD IDYDSIAPKF
     KSCQILTDFD EGKYLKEKPW INSFSDLTLH AIEY