SRR1_CANAL
ID SRR1_CANAL Reviewed; 282 AA.
AC Q59M56; A0A1D8PT09; Q59M67;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Stress response regulator protein 1;
GN Name=SRR1; OrderedLocusNames=CAALFM_CR05610CA;
GN ORFNames=CaO19.13265, CaO19.5843;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=21841121; DOI=10.1128/ec.05188-11;
RA Desai C., Mavrianos J., Chauhan N.;
RT "Candida albicans SRR1, a putative two component response regulator gene,
RT is required for stress adaptation, morphogenesis and virulence.";
RL Eukaryot. Cell 10:1370-1374(2011).
CC -!- FUNCTION: Required for stress adaptation, morphogenesis and virulence.
CC {ECO:0000269|PubMed:21841121}.
CC -!- DISRUPTION PHENOTYPE: Causes defects in hyphal development, reduced
CC resistance to osmotic and oxidative stress, and severe virulence
CC attenuation in the mouse model of disseminated candidiasis.
CC {ECO:0000269|PubMed:21841121}.
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DR EMBL; CP017630; AOW31277.1; -; Genomic_DNA.
DR RefSeq; XP_710798.2; XM_705706.2.
DR AlphaFoldDB; Q59M56; -.
DR SMR; Q59M56; -.
DR BioGRID; 1230671; 1.
DR GeneID; 3647589; -.
DR KEGG; cal:CAALFM_CR05610CA; -.
DR CGD; CAL0000201009; SRR1.
DR VEuPathDB; FungiDB:CR_05610C_A; -.
DR eggNOG; ENOG502SFN6; Eukaryota.
DR HOGENOM; CLU_065405_0_0_1; -.
DR InParanoid; Q59M56; -.
DR OMA; FHKPLNY; -.
DR OrthoDB; 1520369at2759; -.
DR PRO; PR:Q59M56; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0005737; C:cytoplasm; IDA:CGD.
DR GO; GO:0005739; C:mitochondrion; IDA:CGD.
DR GO; GO:0005634; C:nucleus; IDA:CGD.
DR GO; GO:0005782; C:peroxisomal matrix; TAS:CGD.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IMP:CGD.
DR GO; GO:0006915; P:apoptotic process; IMP:CGD.
DR GO; GO:0036180; P:filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR GO; GO:0036178; P:filamentous growth of a population of unicellular organisms in response to neutral pH; IMP:CGD.
DR GO; GO:0036170; P:filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IMP:CGD.
DR GO; GO:1900445; P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR GO; GO:1900442; P:positive regulation of filamentous growth of a population of unicellular organisms in response to neutral pH; IMP:CGD.
DR GO; GO:1900436; P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
DR GO; GO:0006970; P:response to osmotic stress; IMP:CGD.
DR GO; GO:0006979; P:response to oxidative stress; IMP:CGD.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..282
FT /note="Stress response regulator protein 1"
FT /id="PRO_0000413385"
FT DOMAIN 155..273
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT REGION 12..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 43..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 206
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 282 AA; 32139 MW; A48F765EF6603A98 CRC64;
MISMNPIMIR NNLSRSSSPA APPTTNHSST VDYFSIKPKL SLDINSQSDS NSTQSNNNED
THSEQSDYNS YTHNQYYDSD DDEDDFDIRD QLLDPFDKIT LSNCNEEYYS PLTPFDGQTT
SPQDSIISSK SSNKSTTVVP SPQFQLTLPK LTTYSFLIVD DNIINLKILN RILLKLFPKC
HIVQIQDSKL VKDLLHKQSF DSIFIDIEMP DVNGIDIAQF VRQDTKFDNM GMVAVTTRNS
TQDLELFKQC GIDFTFHKPL NYSLDFMANS IDDIIITRKN KI
