ID   SRRDP_PHYPO             Reviewed;         497 AA.
AC   C5IGN8;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Serine/arginine-rich protein PSR {ECO:0000303|PubMed:21149255};
DE   Flags: Precursor;
OS   Physarum polycephalum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Myxogastria;
OC   Myxogastromycetidae; Physariida; Physaraceae; Physarum.
OX   NCBI_TaxID=5791;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ACR15168.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PHOSPHORYLATION, AND MUTAGENESIS OF ARG-464 AND
RP   SER-465.
RC   STRAIN=TU291 {ECO:0000269|PubMed:21149255};
RX   PubMed=21149255; DOI=10.1093/jb/mvq141;
RA   Zhang Y.X., Xing M., Fei X., Zhang J.H., Tian S.L., Li M.H., Liu S.D.;
RT   "Identification of a novel PSR as the substrate of an SR protein kinase in
RT   the true slime mold.";
RL   J. Biochem. 149:275-283(2011).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I
CC       membrane protein {ECO:0000255}.
CC   -!- PTM: Phosphorylated on serine residues in the RS domain by PSRPK.
CC       {ECO:0000269|PubMed:21149255}.
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DR   EMBL; FJ917746; ACR15168.1; -; mRNA.
DR   AlphaFoldDB; C5IGN8; -.
DR   SMR; C5IGN8; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Membrane; Phosphoprotein; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..497
FT                   /note="Serine/arginine-rich protein PSR"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000409665"
FT   TOPO_DOM        20..366
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        367..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        388..497
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          424..450
FT                   /note="Necessary for phosphorylation by PSRPK in vitro"
FT                   /evidence="ECO:0000269|PubMed:21149255"
FT   REGION          436..497
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        472..497
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        92
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        193
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        202
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        261
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        283
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   MUTAGEN         464
FT                   /note="R->K: Reduced phosphorylation by PSRPK."
FT                   /evidence="ECO:0000269|PubMed:21149255"
FT   MUTAGEN         465
FT                   /note="S->T: Reduced phosphorylation by PSRPK."
FT                   /evidence="ECO:0000269|PubMed:21149255"
SQ   SEQUENCE   497 AA;  53530 MW;  A90F1B99D397B9E6 CRC64;
     MYSRCIALVF VGLLASSLAA NCYGPAGKLA VAEFDAFPSP VAVGGTVYIR TNIQPTYDMG
     SATVQLSVYY SDNFDVTGLK PVVDIPGLQL CNLSTSITCP ITAGTHILAW EYRVPDVLPG
     TYQVKYTILE DNPPDGNPYS CIQFSITVEG QKTNEFTSWY QATLLGTALF TQPDYKLRQI
     GEALQVGPSG PLNGSISPVP YNGSIKYLSG SGDLVPNAFY DTSNFVWGLS GTMVKQTIGA
     LGQISHIYQG ECYLGYINNI NTSIAGNFYD YMTPLIDGTF TLNWTYTDSS TAEINGVAQF
     QPAATIPYGW GFPLLYGRLG EHQVVTSDVG FLMIKGNMPF CTSGVCAAPP AQGGSKHHGL
     SSQKLGLAIG LPIAGVFLII LIAAAIIYYR KRRESEKEDG VFAVSRKPEY GSALVVDGII
     EETMGSKTMQ AMLDMRDDDE SEHDSDDGYG RSGQSGRSGR SRSRSRSRSV SRSRSGSRDA
     RSESDPGESA SRDSDSD