SRRM2_MOUSE
ID SRRM2_MOUSE Reviewed; 2703 AA.
AC Q8BTI8; E9QNB0; Q3TBY5; Q569P9; Q80U37; Q8K383;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Serine/arginine repetitive matrix protein 2;
GN Name=Srrm2; Synonyms=Kiaa0324;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-745 (ISOFORM 1).
RC STRAIN=NOD;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-191 (ISOFORM 1), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 2060-2703 (ISOFORM 3).
RC STRAIN=FVB/N, and NMRI; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 944-968; 1338-1349 AND 1924-1932, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 950-2703 (ISOFORMS 1/2).
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1343, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic brain;
RX PubMed=15345747; DOI=10.1074/mcp.m400085-mcp200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain cortex;
RX PubMed=17114649; DOI=10.1074/mcp.m600046-mcp200;
RA Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,
RA Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B.,
RA Panse C., Schlapbach R., Mansuy I.M.;
RT "Qualitative and quantitative analyses of protein phosphorylation in naive
RT and stimulated mouse synaptosomal preparations.";
RL Mol. Cell. Proteomics 6:283-293(2007).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-323; SER-349; SER-351;
RP SER-402; SER-406; SER-433; SER-434; SER-435; THR-841; THR-955; SER-1048;
RP SER-1068; SER-1077; SER-1216; SER-1269; SER-1305; SER-1338; SER-1339;
RP SER-1343; SER-1380; SER-1576; SER-1577; SER-2052; SER-2054; THR-2056;
RP SER-2073; SER-2075; SER-2224 AND SER-2404, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-349; SER-351; SER-433;
RP SER-434; SER-435; SER-773; SER-775; SER-778; SER-1216; SER-1305; SER-2052;
RP SER-2054 AND THR-2056, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Liver;
RX PubMed=18630941; DOI=10.1021/pr800223m;
RA Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
RT "Specific phosphopeptide enrichment with immobilized titanium ion affinity
RT chromatography adsorbent for phosphoproteome analysis.";
RL J. Proteome Res. 7:3957-3967(2008).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-433; SER-434; SER-435;
RP THR-973; SER-1305; SER-1338; SER-1339; SER-1343; SER-1360; SER-1400;
RP SER-1465; THR-1467; SER-2224; SER-2335; SER-2381 AND SER-2404, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-433; SER-434; SER-435;
RP SER-531; SER-533; SER-1151; SER-1338; SER-1339; SER-1343; SER-1360;
RP SER-1572; SER-1576; SER-1577; SER-1982; SER-1984; THR-1986; SER-2052;
RP SER-2054; THR-2056; SER-2224; SER-2335; SER-2351; SER-2404; SER-2646;
RP SER-2648; SER-2656 AND SER-2660, AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=19131326; DOI=10.1074/mcp.m800451-mcp200;
RA Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
RT "Large scale localization of protein phosphorylation by use of electron
RT capture dissociation mass spectrometry.";
RL Mol. Cell. Proteomics 8:904-912(2009).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295; SER-310; SER-323;
RP SER-349; SER-351; SER-402; SER-406; SER-422; SER-433; SER-434; SER-435;
RP SER-438; SER-773; SER-778; SER-829; THR-831; THR-841; SER-882; SER-946;
RP SER-949; THR-955; THR-973; SER-984; SER-993; THR-995; SER-1011; SER-1038;
RP THR-1044; SER-1048; SER-1067; SER-1068; THR-1071; SER-1077; SER-1097;
RP SER-1216; SER-1225; SER-1229; SER-1230; SER-1269; SER-1305; SER-1338;
RP SER-1339; SER-1340; SER-1343; SER-1360; SER-1380; SER-1400; THR-1428;
RP SER-1508; SER-1572; SER-1576; SER-1577; SER-1813; SER-2052; SER-2054;
RP THR-2056; SER-2070; SER-2073; SER-2075; SER-2084; SER-2224; SER-2335;
RP SER-2351; SER-2404; SER-2535 AND SER-2656, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [13]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-101, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
RN [14]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-2146; ARG-2159; ARG-2295 AND
RP ARG-2337, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: Required for pre-mRNA splicing as component of the
CC spliceosome. {ECO:0000250|UniProtKB:Q9UQ35}.
CC -!- SUBUNIT: Component of pre-catalytic, catalytic and post-catalytic
CC spliceosome complexes. Found in a pre-mRNA splicing complex with SFRS4,
CC SFRS5, SNRP70, SNRPA1, SRRM1 and SRRM2. {ECO:0000250|UniProtKB:Q9UQ35}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UQ35}. Nucleus
CC speckle {ECO:0000250|UniProtKB:Q9UQ35}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BTI8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BTI8-2; Sequence=VSP_020188;
CC Name=3;
CC IsoId=Q8BTI8-3; Sequence=VSP_020189;
CC -!- SIMILARITY: Belongs to the CWC21 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH27781.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK090123; BAC41104.1; -; mRNA.
DR EMBL; AK171001; BAE42172.1; -; mRNA.
DR EMBL; AC122821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027781; AAH27781.1; ALT_INIT; mRNA.
DR EMBL; BC092355; AAH92355.1; -; mRNA.
DR EMBL; AK122248; BAC65530.1; -; mRNA.
DR CCDS; CCDS37475.1; -. [Q8BTI8-2]
DR CCDS; CCDS89004.1; -. [Q8BTI8-1]
DR RefSeq; NP_780438.2; NM_175229.3. [Q8BTI8-2]
DR RefSeq; XP_006525139.1; XM_006525076.3.
DR RefSeq; XP_006525140.1; XM_006525077.3. [Q8BTI8-1]
DR SMR; Q8BTI8; -.
DR BioGRID; 217871; 64.
DR IntAct; Q8BTI8; 4.
DR MINT; Q8BTI8; -.
DR STRING; 10090.ENSMUSP00000085993; -.
DR iPTMnet; Q8BTI8; -.
DR PhosphoSitePlus; Q8BTI8; -.
DR SwissPalm; Q8BTI8; -.
DR REPRODUCTION-2DPAGE; IPI00225062; -.
DR REPRODUCTION-2DPAGE; IPI00785240; -.
DR EPD; Q8BTI8; -.
DR jPOST; Q8BTI8; -.
DR MaxQB; Q8BTI8; -.
DR PaxDb; Q8BTI8; -.
DR PeptideAtlas; Q8BTI8; -.
DR PRIDE; Q8BTI8; -.
DR ProteomicsDB; 258605; -. [Q8BTI8-1]
DR ProteomicsDB; 258606; -. [Q8BTI8-2]
DR ProteomicsDB; 258607; -. [Q8BTI8-3]
DR Antibodypedia; 52249; 104 antibodies from 19 providers.
DR DNASU; 75956; -.
DR Ensembl; ENSMUST00000088621; ENSMUSP00000085993; ENSMUSG00000039218. [Q8BTI8-2]
DR Ensembl; ENSMUST00000190686; ENSMUSP00000139842; ENSMUSG00000039218. [Q8BTI8-1]
DR GeneID; 75956; -.
DR KEGG; mmu:75956; -.
DR UCSC; uc008atn.1; mouse. [Q8BTI8-1]
DR CTD; 23524; -.
DR MGI; MGI:1923206; Srrm2.
DR VEuPathDB; HostDB:ENSMUSG00000039218; -.
DR eggNOG; KOG1869; Eukaryota.
DR GeneTree; ENSGT00940000161127; -.
DR HOGENOM; CLU_000647_0_0_1; -.
DR InParanoid; Q8BTI8; -.
DR OMA; KTTVMVK; -.
DR OrthoDB; 191983at2759; -.
DR TreeFam; TF335721; -.
DR Reactome; R-MMU-72163; mRNA Splicing - Major Pathway.
DR BioGRID-ORCS; 75956; 5 hits in 26 CRISPR screens.
DR ChiTaRS; Srrm2; mouse.
DR PRO; PR:Q8BTI8; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8BTI8; protein.
DR Bgee; ENSMUSG00000039218; Expressed in rostral migratory stream and 223 other tissues.
DR ExpressionAtlas; Q8BTI8; baseline and differential.
DR Genevisible; Q8BTI8; MM.
DR GO; GO:0015030; C:Cajal body; ISO:MGI.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; ISO:MGI.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; ISS:UniProtKB.
DR GO; GO:0071005; C:U2-type precatalytic spliceosome; ISS:UniProtKB.
DR GO; GO:0070742; F:C2H2 zinc finger domain binding; ISO:MGI.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0047485; F:protein N-terminus binding; ISO:MGI.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR InterPro; IPR013170; mRNA_splic_Cwf21_dom.
DR InterPro; IPR024945; Spt5_C_dom.
DR Pfam; PF08312; cwf21; 1.
DR SMART; SM01104; CTD; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Coiled coil; Direct protein sequencing;
KW Isopeptide bond; Methylation; mRNA processing; mRNA splicing; Nucleus;
KW Phosphoprotein; Reference proteome; Spliceosome; Ubl conjugation.
FT CHAIN 1..2703
FT /note="Serine/arginine repetitive matrix protein 2"
FT /id="PRO_0000248155"
FT REGION 141..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..259
FT /note="Sufficient for RNA-binding"
FT /evidence="ECO:0000250"
FT REGION 1024..1112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1136..2092
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2263..2703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 60..92
FT /evidence="ECO:0000255"
FT COMPBIAS 209..256
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..418
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..530
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..717
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..928
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..946
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..1005
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1024..1077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1090..1110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1241..1255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1281..1301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1353..1377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1392..1435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1450..1514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1598..1617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1618..1659
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1727..1741
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1756..1776
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1792..1816
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1823..2016
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2026..2074
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2264..2286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2311..2329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2362..2377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2384..2398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2406..2446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2466..2522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2544..2558
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2559..2606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2621..2640
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2641..2672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2673..2695
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 101
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 145
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 169
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 220
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 222
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 295
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 300
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 310
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 322
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 323
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 349
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:18630941, ECO:0007744|PubMed:21183079"
FT MOD_RES 351
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:18630941, ECO:0007744|PubMed:21183079"
FT MOD_RES 355
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 356
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 357
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 365
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 375
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 385
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 393
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 396
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 402
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 406
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 422
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 433
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:18630941, ECO:0007744|PubMed:19131326,
FT ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"
FT MOD_RES 434
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:18630941, ECO:0007744|PubMed:19131326,
FT ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"
FT MOD_RES 435
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:18630941, ECO:0007744|PubMed:19131326,
FT ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"
FT MOD_RES 438
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 452
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 482
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 484
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 503
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 505
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 507
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 531
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19131326"
FT MOD_RES 533
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19131326"
FT MOD_RES 540
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 700
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 702
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 704
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 773
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18630941,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 775
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18630941"
FT MOD_RES 778
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18630941,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 821
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 829
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 831
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 841
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 846
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 850
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 851
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 882
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 909
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 924
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 926
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 928
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 940
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 942
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 944
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 945
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 946
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 949
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 955
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 962
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 964
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 966
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 973
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 980
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 984
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 993
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 995
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 997
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1000
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1011
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1037
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1038
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1044
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1048
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 1064
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1066
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1067
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1068
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 1071
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1077
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 1087
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1094
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1097
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1117
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1151
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19131326"
FT MOD_RES 1159
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1175
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1188
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1216
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:18630941, ECO:0007744|PubMed:21183079"
FT MOD_RES 1225
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1229
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1230
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1269
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 1276
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1278
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1284
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1287
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1294
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1305
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:18630941, ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 1325
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1338
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 1339
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 1340
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1343
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:15345747,
FT ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:19131326,
FT ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"
FT MOD_RES 1359
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1360
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19131326,
FT ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"
FT MOD_RES 1370
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1372
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1378
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1380
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 1390
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1400
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 1407
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1409
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1414
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1416
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1418
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1419
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1428
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1438
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1439
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1448
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1453
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1455
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1457
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1458
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1465
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT MOD_RES 1467
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT MOD_RES 1473
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1475
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1477
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1478
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1487
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1493
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1495
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1497
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1498
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1508
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1533
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1535
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1537
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1538
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1554
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1556
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1557
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1572
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19131326,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 1576
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:21183079"
FT MOD_RES 1577
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:21183079"
FT MOD_RES 1604
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1614
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1647
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1649
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1650
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1654
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1683
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1685
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1687
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1688
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1718
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1720
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1774
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1778
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1810
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1813
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1832
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1834
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1836
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1840
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1846
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1848
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1849
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1869
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1872
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1876
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1878
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1880
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1884
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1898
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1900
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1902
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1906
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1910
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1912
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1914
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1918
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1922
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1924
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1927
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1930
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1936
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1939
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1948
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1951
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1960
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1963
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1970
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1972
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1974
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1982
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19131326"
FT MOD_RES 1984
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19131326"
FT MOD_RES 1986
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:19131326"
FT MOD_RES 1994
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1996
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 1998
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2019
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2021
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2023
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2042
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2044
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2052
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:18630941, ECO:0007744|PubMed:19131326,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 2054
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:18630941, ECO:0007744|PubMed:19131326,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 2056
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:18630941, ECO:0007744|PubMed:19131326,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 2070
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2073
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 2075
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 2084
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2096
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2146
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 2159
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 2183
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2198
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2224
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 2226
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2240
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2241
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2254
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2262
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2268
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2281
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2295
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 2296
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2321
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2329
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2334
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2335
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19131326,
FT ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"
FT MOD_RES 2337
FT /note="Asymmetric dimethylarginine; alternate"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 2337
FT /note="Omega-N-methylarginine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2347
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2351
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19131326,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 2360
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2362
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2365
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2368
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2381
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT MOD_RES 2384
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2404
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 2408
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2535
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2537
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2553
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2618
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2629
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2631
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2638
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2642
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2644
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2646
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19131326"
FT MOD_RES 2648
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19131326"
FT MOD_RES 2656
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19131326,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 2660
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19131326"
FT MOD_RES 2689
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT MOD_RES 2691
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT CROSSLNK 108
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT CROSSLNK 130
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT CROSSLNK 2541
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UQ35"
FT VAR_SEQ 1..96
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_020188"
FT VAR_SEQ 2486..2585
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020189"
FT CONFLICT 373
FT /note="V -> D (in Ref. 1; BAC41104/BAE42172)"
FT /evidence="ECO:0000305"
FT CONFLICT 428
FT /note="G -> V (in Ref. 1; BAC41104/BAE42172)"
FT /evidence="ECO:0000305"
FT CONFLICT 618
FT /note="A -> T (in Ref. 1; BAC41104/BAE42172)"
FT /evidence="ECO:0000305"
FT CONFLICT 927
FT /note="I -> V (in Ref. 1; BAC41104)"
FT /evidence="ECO:0000305"
FT CONFLICT 967
FT /note="L -> P (in Ref. 1; BAC41104 and 5; BAC65530)"
FT /evidence="ECO:0000305"
FT CONFLICT 1255
FT /note="E -> G (in Ref. 1; BAC41104)"
FT /evidence="ECO:0000305"
FT CONFLICT 1639
FT /note="H -> R (in Ref. 1; BAC41104 and 5; BAC65530)"
FT /evidence="ECO:0000305"
FT CONFLICT 1835
FT /note="R -> I (in Ref. 1; BAC41104)"
FT /evidence="ECO:0000305"
FT CONFLICT 2418
FT /note="V -> A (in Ref. 1; BAC41104, 3; AAH27781 and 5;
FT BAC65530)"
FT /evidence="ECO:0000305"
FT CONFLICT 2628
FT /note="R -> G (in Ref. 1; BAC41104)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2703 AA; 294840 MW; F144CB3EB1E8DF5B CRC64;
MYNGIGLPTP RGSGTNGYVQ RNLSLVRGRR GERPDYKGEE ELRHLEAALV KRPNPDILDH
ERKRRVELRC LELEEMMEEQ GYEEQQIQEK VATFRLMLLE KDVNPGAKEE TPGQRPVVTE
THQLAELNEK KNERLRAAFG ISDSYVDGSS FDPQRRAREA KQIAPEPPKP YSLVRETSSS
RSPTPKQKKK KKKKDRGRRS ESSSPRRERK KSSKKKKHRS ESESKKRKHR SPTPKSKRKS
KDKKRKRSRS TTPAPKSRRA HRSTSADSAS SSDTSRSRSR SAAAKIHTTA LTGQSPPLAS
GHQGEGDAPS VEPGATNIQQ PSSPAPSTKQ SSSPYEDKDK KEKSAVRPSP SPERSSTGPE
LPAPTPLLVE QHVDSPRPLA AIPSSQEPVN PSSEASPTRG CSPPKSPEKP PQSTSSESCP
PSPQPTKGSR HASSSPESLK PTPAPGSRRE ISSSPTSKNR SHGRAKRDKS HSHTPSHRAG
RSRSPATKRG RSRSRTPTKR GHSRSRSPQW RRSRSAQRWG KSRSPQRRGR SRSPQRPGWS
RSRNTQRRGR SRSARRGRSH SRSPATRGRS RSRTPARRGR SRSRTPARRR SRSRTPARRR
SRSRTPARRG RSRSRTPARR RSRTRSPVRR RSRSRSQARR SGRSRSRTPA RRSGRSRSRT
PARRGRSRSR TPARRSARSR SRTPARRGRS RSRTPARRRS RSRSLVRRGR SHSRTPQRRG
RSGSSSERKN KSRTSQRRSR SNSSPEMKKS HVSSRRSRSL SSPRSKAKSL RRSLSGSSPC
PKQKSQTPTR RSRSGSSPPK QKSKTPPRQS RSNSPQPKVK SGTPPRPGSV TNMQADECTA
TPQRQSHSES SPDGEVKSRT PSRQSCSGSS PRVKSSTPPR QSPSRSSSPQ PKVKTVISPR
GRSHSSSSSP SPSRVTSRTP QRKSRSISPC PKVDSRLRHS RSRSSSPDSK MELGTPLRHS
GSTSPYLKSM LQTPPDQNLS GSKSPCPQKS RDSPTGSSGS FHLCPGVTPS SIVPGESCFS
ASFVQQKGHT QTWPDTSSPE VMQTQVESPL LQSKSQTSPK GSLSRSSSPV TELTARSPVK
QDKSEISTDP KLKSGMSPEQ SKTKPDSSIY PLVDSKSFLV QSRLEPSELK ERLGLIQEDV
ASSCIPRDKF SPTQDRPESS TVLKVTPRVL LKERSGAGSP PGKRDQKSLL PNSSQDELME
VEKSEQPLSQ VLPSLSPEHK EMPGSNIESS PEVEERPAVL SALDQSQSQP SKAAETPAVA
SCWSGPQVSP EHKELSHSPP RENSFESSLE FKNSGPVSEV NTGFSPEVKE ELNGSFLNQT
EADPSVDMKE QSRSSRRSSS ELSPEVVEKV GLFSSQKVSS PVLETVQQRT PSRERSSSAS
PELKDGLPRT PSRRSRSGSS PGLRDGSGTP SRHSLSGSSP GMKDTPQTPS RGRSECDSSP
EPKALPQTPR ARSHSPSSPE RNNKSVTPQR ERSGSESSVE QKNLARTSPG QRSRSGSSQE
LDGKPSASPQ ERSESDSSPD SKPKTRTPLR QRSHSGSSPE VDSKSRHSPR LSRSGSSPEM
KDKPRVLQRA QSGTDSSPEH KIPAPRALPR HSRSGSSSKE RGPSPEGSSS SESSPEHAPK
SRTARRGSRS SIEPKTKSHT PPRRRSSRSS PELTRKARVS RRSRSASSSP EIRSRTPPRR
RRSPSVSSPE PTEKSRSSRR RRSVSSPRTK TTSRRGRSPS PKPRGLQRSR SRSRREKTRT
TRRRDRSGSS QSTSRRRQRS RSRSRVTRRR RGGSGYHSRS PTRQESSRTS SRRRRGRSRT
PLTSRKRSRS RTSPAPWKRS RSRASPATHR RSRSRTPLIS RRRSRSRTSP VSRRRSRSVN
RRRSRSRASP VSRRRSRSRT PPVTRRRSRS RTPTRRRSRS RTPPVTRRRS RSRTPPVTRR
RSRSRTSPVT RRRSRSRTSP VTRRRSRSRT SPVTRRRSRS RTSPVTRRRS RSRTPPAIRR
RSRSRTPLLP RKRSRSRSPL AIRRRSRSRT PRAARGKRSL TRSPPAIRRR SASGSSSDRS
RSATPPATRN HSGSRTPPVA LSSSRMSCFS RPSMSPTPLD RCRSPGMLEP LGSARTPMSV
LQQTGGSMMD GPGPRIPDHP RSSVPENHAQ SRIALALTAI SLGTARPPPS MSAAGLAARM
SQVPAPVPLM SLRTAPAANL ASRIPAASAA AMNLASARTS AIPASVNLAD SRTPAAAAAM
NLASPRTAVA PSAVNLADPR TPAASAVNLA GARTPAALAA LSLTGSGTPP TAANYPSSSR
TPQAPTPANL VVGPRSAHGT APVNIAGSRT PAGLAPTNLS SSRMAPALSG ANLTSPRVPL
SAYDRVSGRT SPLMLDRARS RTPPSAPSQS RMTSERERAP SPASRMVQAS SQSLLPPAQD
RPRSPVPSAF SDQSRSVVQT TPVAGSQSLS SGTVAKSTSS ASDHNGMLSG PAPGISHAEG
GEPPASTGAQ QPSTLAALQP AKERRSSSSS SSSSSSSSSS SSSSSSSSSS GSSSSDSEGS
SLPAQPEVAL KRVPSPTPVP KEAIREGRPQ EPTPAKRKRR SSSSSSSSSS SSSSSSSSSS
SSSSSSSSSS SSSSSSSSSS SSPSPAKPGP QALPKPASPK KPPPGERRSR SPRKPIDSLR
DSRSLSYSPV ERRQPSPQPS PRDLQSSERV SWRGQRGDSH SPGHKRKETP SPRSNRHRSS
RSP
