SRRM3_HUMAN
ID SRRM3_HUMAN Reviewed; 597 AA.
AC A6NNA2; A6ND75;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 4.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Serine/arginine repetitive matrix protein 3;
GN Name=SRRM3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-351.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=26053433; DOI=10.1038/srep11207;
RA Lee N.S., Evgrafov O.V., Souaiaia T., Bonyad A., Herstein J., Lee J.Y.,
RA Kim J., Ning Y., Sixto M., Weitz A.C., Lenz H.J., Wang K., Knowles J.A.,
RA Press M.F., Salvaterra P.M., Shung K.K., Chow R.H.;
RT "Non-coding RNAs derived from an alternatively spliced REST transcript
RT (REST-003) regulate breast cancer invasiveness.";
RL Sci. Rep. 5:11207-11207(2015).
RN [4]
RP FUNCTION.
RX PubMed=27748911; DOI=10.3892/ijo.2016.3718;
RA Zhou H., Li J., Zhang Z., Ye R., Shao N., Cheang T., Wang S.;
RT "RING1 and YY1 binding protein suppresses breast cancer growth and
RT metastasis.";
RL Int. J. Oncol. 49:2442-2452(2016).
CC -!- FUNCTION: May play a role in regulating breast cancer cell invasiveness
CC (PubMed:26053433). May be involved in RYBP-mediated breast cancer
CC progression (PubMed:27748911). {ECO:0000269|PubMed:26053433,
CC ECO:0000269|PubMed:27748911}.
CC -!- TISSUE SPECIFICITY: Expressed in breast cancer cell lines.
CC {ECO:0000269|PubMed:26053433}.
CC -!- SIMILARITY: Belongs to the CWC21 family. {ECO:0000305}.
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DR EMBL; AC005077; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC029292; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; A6NNA2; -.
DR SMR; A6NNA2; -.
DR STRING; 9606.ENSP00000480851; -.
DR iPTMnet; A6NNA2; -.
DR PhosphoSitePlus; A6NNA2; -.
DR BioMuta; SRRM3; -.
DR jPOST; A6NNA2; -.
DR MassIVE; A6NNA2; -.
DR PaxDb; A6NNA2; -.
DR PeptideAtlas; A6NNA2; -.
DR PRIDE; A6NNA2; -.
DR ProteomicsDB; 1593; -.
DR GeneCards; SRRM3; -.
DR HGNC; HGNC:26729; SRRM3.
DR neXtProt; NX_A6NNA2; -.
DR eggNOG; KOG1869; Eukaryota.
DR InParanoid; A6NNA2; -.
DR TreeFam; TF335721; -.
DR PathwayCommons; A6NNA2; -.
DR ChiTaRS; SRRM3; human.
DR Pharos; A6NNA2; Tdark.
DR PRO; PR:A6NNA2; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; A6NNA2; protein.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR InterPro; IPR013170; mRNA_splic_Cwf21_dom.
DR InterPro; IPR029360; SRRM_C.
DR Pfam; PF08312; cwf21; 1.
DR Pfam; PF15230; SRRM_C; 1.
DR SMART; SM01115; cwf21; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..597
FT /note="Serine/arginine repetitive matrix protein 3"
FT /id="PRO_0000341375"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..185
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..239
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..415
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..553
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 27
FT /note="S -> A (in Ref. 2; BC029292)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 597 AA; 65249 MW; EBD575BAE48F8AA8 CRC64;
MSSTVNNGAA SMQSTPDAAN GFPQPSSSSG TWPRAEEELR AAEPGLVKRA HREILDHERK
RRVELKCMEL QEMMEEQGYS EEEIRQKVGT FRQMLMEKEG VLTREDRPGG HIVAETPRLT
EGAEPGLEYA PFDDDDGPVD CDCPASCYRG HRGYRTKHWS SSSASPPPKK KKKKKGGHRR
SRKKRRLESE CSCGSSSPLR KKKKSVKKHR RDRSDSGSRR KRRHRSRSSK CKRKEKNKEK
KRPHTESPGR RSHRHSSGSS HSPSLSSHYS DSRSPSRLSP KHRDEGRKTG SQRSSGSRSP
SPSGGSGWGS PQRNGGSGQR SGAHGGRPGS AHSPPDKPSS PSPRVRDKAA AAAPTPPARG
KESPSPRSAP SSQGRGGRAA GGAGRRRRRR RRRRRSRSSA SAPRRRGRRR PRPAPPRGSS
RSLSRARSSS DSGSGRGAPG PGPEPGSERG HGGHGKRAKE RPPRARPAST SPSPGAHGRR
GGPEGKSSSR SPGPHPRSWS SSRSPSKSRS RSAEKRPHSP SRSPSPKKPL SRDKDGEGRA
RHSEAEATRA RRRSRSYSPI RKRRRDSPSF MEPRRITSAA SVLFHTTGPA PLPPPAA
