SRRM3_MOUSE
ID SRRM3_MOUSE Reviewed; 648 AA.
AC Q80WV7; Q9CUV5; Q9JJ91;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Serine/arginine repetitive matrix protein 3;
GN Name=Srrm3; ORFNames=MNCb-4760;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 113-231.
RC STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May play a role in regulating breast cancer cell
CC invasiveness. May be involved in RYBP-mediated breast cancer
CC progression. {ECO:0000250|UniProtKB:A6NNA2}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q80WV7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80WV7-2; Sequence=VSP_034270, VSP_034271;
CC -!- SIMILARITY: Belongs to the CWC21 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB29002.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB041661; BAA95106.1; -; mRNA.
DR EMBL; BC051947; AAH51947.1; -; mRNA.
DR EMBL; AK013812; BAB29002.1; ALT_INIT; mRNA.
DR CCDS; CCDS39319.2; -. [Q80WV7-1]
DR RefSeq; NP_067378.2; NM_021403.3. [Q80WV7-1]
DR RefSeq; XP_006504534.1; XM_006504471.1. [Q80WV7-1]
DR RefSeq; XP_006504535.1; XM_006504472.2. [Q80WV7-1]
DR AlphaFoldDB; Q80WV7; -.
DR SMR; Q80WV7; -.
DR BioGRID; 208393; 16.
DR STRING; 10090.ENSMUSP00000115695; -.
DR iPTMnet; Q80WV7; -.
DR PhosphoSitePlus; Q80WV7; -.
DR PaxDb; Q80WV7; -.
DR PRIDE; Q80WV7; -.
DR ProteomicsDB; 257403; -. [Q80WV7-1]
DR ProteomicsDB; 257404; -. [Q80WV7-2]
DR Antibodypedia; 8308; 61 antibodies from 9 providers.
DR Ensembl; ENSMUST00000144211; ENSMUSP00000115695; ENSMUSG00000039860. [Q80WV7-1]
DR GeneID; 58212; -.
DR KEGG; mmu:58212; -.
DR UCSC; uc008zza.1; mouse. [Q80WV7-2]
DR UCSC; uc008zzc.1; mouse. [Q80WV7-1]
DR CTD; 222183; -.
DR MGI; MGI:1920309; Srrm3.
DR VEuPathDB; HostDB:ENSMUSG00000039860; -.
DR eggNOG; KOG1869; Eukaryota.
DR GeneTree; ENSGT00940000162625; -.
DR HOGENOM; CLU_027803_0_0_1; -.
DR InParanoid; Q80WV7; -.
DR OMA; CTEFEML; -.
DR OrthoDB; 1397544at2759; -.
DR PhylomeDB; Q80WV7; -.
DR TreeFam; TF335721; -.
DR BioGRID-ORCS; 58212; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Srrm3; mouse.
DR PRO; PR:Q80WV7; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q80WV7; protein.
DR Bgee; ENSMUSG00000039860; Expressed in retinal neural layer and 105 other tissues.
DR ExpressionAtlas; Q80WV7; baseline and differential.
DR Genevisible; Q80WV7; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR InterPro; IPR013170; mRNA_splic_Cwf21_dom.
DR InterPro; IPR029360; SRRM_C.
DR Pfam; PF08312; cwf21; 1.
DR Pfam; PF15230; SRRM_C; 1.
DR SMART; SM01115; cwf21; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..648
FT /note="Serine/arginine repetitive matrix protein 3"
FT /id="PRO_0000341376"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..185
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..239
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..412
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..548
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..574
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 112
FT /note="I -> M (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_034270"
FT VAR_SEQ 113..648
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_034271"
FT CONFLICT 93
FT /note="Q -> P (in Ref. 1; BAA95106)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 648 AA; 71104 MW; AA30FC7A02C070AE CRC64;
MSSTVNNGAT GMPAPPDAAN GFPQPGASSG SWPRAEEELR AAEPGLVKRA HREILDHERK
RRVELKCMEL QEMMEEQGYS EEEIRQKVGT FRQMLMEKEG VLTREDRPGA HIVAETPRRM
EGLEPGLEYP PFDEDDGPVD CDCPVSCYRG HRGYRTKHWS SSSASPPPKK KKKKKGSHRR
SRKKRRLESE CSCGSASPLR KKKKNVKKHR RDRSDSGSRR KRRYRSRSLK SKRKEKNKER
KRPHTESPGR RFHHHSSASS HSPSMSSHYS DSGSPSRLSP KHRDDGRKTG SQRSSGSRSP
SPSGGSGWGS PQQNGGSRQR SGAHGGRPGS AHSPPDKPSS PRACDKAAAA PTPPARGKDS
QSPRSAPSSQ GRGGRAAGGT ARRRRRRRRR RRSRSSANAP RRRGRRRTKP APPRGSSRSL
SGAHSSSDSG GGAPGPGPEP CSERGHGGHG KRAKERPPRA RPASTSPSPG TRGRRGGPEG
NSSSRSPGPH QGSWSSSRSP SKSHSRSPDK RTRSPSLSPS PKKPLGRDKD SEGRARHAEA
EAARTRRRSR SYSPIRKRRR DSPSFMEPRR ITSARKRPIP YYRPSPSSSS SCLSTDYSSR
SHSRSPSPGH SHGSYSSRSH GTRSRSCSAS RSRSPSYHSR SSSESGGF
