SRRM4_DANRE
ID SRRM4_DANRE Reviewed; 574 AA.
AC P0CB65;
DT 15-DEC-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2009, sequence version 1.
DT 03-AUG-2022, entry version 35.
DE RecName: Full=Serine/arginine repetitive matrix protein 4;
DE AltName: Full=Neural-specific serine/arginine repetitive splicing factor of 100 kDa;
DE Short=ZnSR100;
DE Short=nSR100;
GN Name=srrm4;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP IDENTIFICATION, FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=19737518; DOI=10.1016/j.cell.2009.06.012;
RA Calarco J.A., Superina S., O'Hanlon D., Gabut M., Raj B., Pan Q.,
RA Skalska U., Clarke L., Gelinas D., van der Kooy D., Zhen M., Ciruna B.,
RA Blencowe B.J.;
RT "Regulation of vertebrate nervous system alternative splicing and
RT development by an SR-related protein.";
RL Cell 138:898-910(2009).
CC -!- FUNCTION: Splicing factor specifically required for neural cell
CC differentiation (PubMed:19737518). Acts in conjunction with nPTB/PTBP2
CC by binding directly to its regulated target transcripts and promotes
CC neural-specific exon inclusion in many genes that function in neural
CC cell differentiation. Required to promote the inclusion of neural-
CC specific exon 10 in nPTB/PTBP2, leading to increased expression of
CC neural-specific nPTB/PTBP2 (By similarity).
CC {ECO:0000250|UniProtKB:Q8BKA3, ECO:0000269|PubMed:19737518}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BKA3}.
CC -!- DEVELOPMENTAL STAGE: At 24 hour postfertilization (hpf), significant
CC expression is observed in the developing brain, including the tectum
CC and telencephalon. Expression is also observed around the trigeminal
CC ganglion, at the mid-hindbrain boundary, and throughout the hindbrain.
CC At 36 hpf, additional expression is observed in the cerebellum and
CC within the retina. At 48 hpf, stronger and more widespread expression
CC is detected throughout the developing eyes brain.
CC {ECO:0000269|PubMed:19737518}.
CC -!- SIMILARITY: Belongs to the nSR100 family. {ECO:0000305}.
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DR EMBL; BX649391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P0CB65; -.
DR PRIDE; P0CB65; -.
DR ZFIN; ZDB-GENE-050208-34; srrm4.
DR InParanoid; P0CB65; -.
DR PRO; PR:P0CB65; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005684; C:U2-type spliceosomal complex; IDA:ZFIN.
DR GO; GO:0003729; F:mRNA binding; ISS:UniProtKB.
DR GO; GO:0007409; P:axonogenesis; IMP:ZFIN.
DR GO; GO:0030154; P:cell differentiation; IMP:UniProtKB.
DR GO; GO:0021754; P:facial nucleus development; IGI:ZFIN.
DR GO; GO:0006397; P:mRNA processing; IMP:UniProtKB.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IDA:ZFIN.
DR GO; GO:0007399; P:nervous system development; IMP:UniProtKB.
DR GO; GO:0042551; P:neuron maturation; IGI:ZFIN.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; ISS:UniProtKB.
DR GO; GO:0043484; P:regulation of RNA splicing; IMP:UniProtKB.
DR InterPro; IPR029360; SRRM_C.
DR Pfam; PF15230; SRRM_C; 1.
PE 2: Evidence at transcript level;
KW Differentiation; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; RNA-binding.
FT CHAIN 1..574
FT /note="Serine/arginine repetitive matrix protein 4"
FT /id="PRO_0000390460"
FT REGION 45..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..87
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..185
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..473
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 574 AA; 65522 MW; 796F37459D4569C4 CRC64;
MAGVQQGEKQ LFEKFWRGTF KAVATPRPES IIVASITARR AVTKLETPVG PKDDEEKVKA
KDLVTKTHEK NGHIKRRGRK RHSHRRARSV SFDADLSPRP VPKTKKKKKK SQRKRRRHRS
PSCSPSPVRK KKKKKSSKKR KRHRSASRKG RHSGSSSRRK RKEDKKHKKR SRSHSHRRHR
HRKAEIRSSS CMENRSEDCE KSGFRDGGRS SDVHGGDACR SAVKLTNKIS SKCCCHFSES
TVSPSRSGVE GLSKVVIVQN SESSDGKRRA DYDSGNDTSS PPSSKTGITR SKVAGNGKFS
CLTSPEKLRL ADGDNASDSG NSLTSYDSLG KPLLRENTLH SSVFSKLKGE ESGRFCVDVE
KTQPLDLISD RNRSPSHDRY EDGTRSRSRS ISSQSRYSGR HSRSRSLSSG RRSYSRSSSY
SLASRRDSLS SVSSCRSLNH SRCTTHRFRE RKRYCSSCKS RKHSRRRPSS PMRKRRRDSP
SHLEARRITS ARKRPIPYYR PSPSVSSRSS SILSWRLFPL TRSRTRSRSC SRSRSRSHSH
TYSSYRSYSR SSSWNSLYSR RSRSRSRSYS RARR
