SRRM5_HUMAN
ID SRRM5_HUMAN Reviewed; 715 AA.
AC B3KS81; B4DNF0;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 3.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Serine/arginine repetitive matrix protein 5;
GN Name=SRRM5; Synonyms=ZNF576;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- CAUTION: Overlaps in opposite strand with ZNF428. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAG60212.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK297891; BAG60212.1; ALT_INIT; mRNA.
DR EMBL; AK093056; BAG52643.1; -; mRNA.
DR EMBL; AX747890; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC006276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS46095.1; -.
DR RefSeq; NP_001139113.1; NM_001145641.1.
DR AlphaFoldDB; B3KS81; -.
DR BioGRID; 936857; 1.
DR IntAct; B3KS81; 1.
DR STRING; 9606.ENSP00000476253; -.
DR iPTMnet; B3KS81; -.
DR PhosphoSitePlus; B3KS81; -.
DR BioMuta; SRRM5; -.
DR MassIVE; B3KS81; -.
DR PaxDb; B3KS81; -.
DR PeptideAtlas; B3KS81; -.
DR PRIDE; B3KS81; -.
DR ProteomicsDB; 3626; -.
DR Antibodypedia; 48986; 5 antibodies from 5 providers.
DR DNASU; 100170229; -.
DR Ensembl; ENST00000417606.3; ENSP00000414512.1; ENSG00000226763.5.
DR Ensembl; ENST00000607544.1; ENSP00000476253.1; ENSG00000226763.5.
DR GeneID; 100170229; -.
DR KEGG; hsa:100170229; -.
DR MANE-Select; ENST00000417606.3; ENSP00000414512.1; NM_001145641.2; NP_001139113.1.
DR UCSC; uc002oxb.5; human.
DR CTD; 100170229; -.
DR GeneCards; SRRM5; -.
DR HGNC; HGNC:37248; SRRM5.
DR HPA; ENSG00000226763; Tissue enriched (testis).
DR neXtProt; NX_B3KS81; -.
DR OpenTargets; ENSG00000226763; -.
DR VEuPathDB; HostDB:ENSG00000226763; -.
DR eggNOG; ENOG502SFJH; Eukaryota.
DR GeneTree; ENSGT00730000111657; -.
DR HOGENOM; CLU_027650_1_0_1; -.
DR InParanoid; B3KS81; -.
DR OMA; ERDHSQT; -.
DR OrthoDB; 710781at2759; -.
DR PhylomeDB; B3KS81; -.
DR PathwayCommons; B3KS81; -.
DR SignaLink; B3KS81; -.
DR BioGRID-ORCS; 100170229; 9 hits in 1071 CRISPR screens.
DR GenomeRNAi; 100170229; -.
DR Pharos; B3KS81; Tdark.
DR PRO; PR:B3KS81; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; B3KS81; protein.
DR Bgee; ENSG00000226763; Expressed in left testis and 105 other tissues.
DR Genevisible; B3KS81; HS.
DR InterPro; IPR038787; SRRM5.
DR PANTHER; PTHR39414; PTHR39414; 3.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..715
FT /note="Serine/arginine repetitive matrix protein 5"
FT /id="PRO_0000395306"
FT REGION 1..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..133
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..318
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..598
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..626
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 375
FT /note="R -> G (in Ref. 1; BAG60212)"
FT /evidence="ECO:0000305"
FT CONFLICT 437
FT /note="C -> R (in Ref. 1; BAG60212)"
FT /evidence="ECO:0000305"
FT CONFLICT 639
FT /note="S -> R (in Ref. 1; BAG60212)"
FT /evidence="ECO:0000305"
FT CONFLICT 694
FT /note="D -> N (in Ref. 1; BAG60212)"
FT /evidence="ECO:0000305"
FT CONFLICT 712
FT /note="S -> P (in Ref. 1; BAG52643/AX747890)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 715 AA; 80355 MW; 1AF0665D74CAAF26 CRC64;
MSSPKRSSKP SMSLAPSGSS MPTADPKPPA SLKSTKSATP NRSLVPTKPA TSRNSVMSPS
SSKSTKSTST KRAPSNRPSS RSRVRSKART PSRVSTDTRT SKASKASDVR CHQRRGTHSR
GRTPGRRGSR SSKRSPSRAS TPGRIRTHGA RPGMASRVRT PTSQQKGSRG KSYGRPRTSN
RERSDSQPRN LSKKSYRPPG GSGIGRSSEL AVTPSTAKCQ TPTGIPSKEK SDNPSPSSSR
KVKSYGQMII PSREKSYSPT EMSSRVKSYN QASTRSRPQS HSQSRSPRRS RSGSQKRTHS
RVRSHSWKRN HSRARSRTRK GILSQMGRHS QSRSHSKGKS QNQSRTPRRG RSHNWSRNPS
KERSHSHSRS SSKERDHRGS SSPRKESGRS QSGSPNKQRD HSRSRSPNKA RDRSRSRSPY
KARDRSRSRS PNKARDCSRS RSPYKARDRS RSRSPNKARD HSRSRSPNKA RDRSRSRSPS
KERDHSQLGS PSKERDHRRS RSPSKERQCR QSRSSSKERD HRRSRSPSKE RQRRQSRSPN
KERDRSQSRS PSEEREHRQS RSPSKERDRR RWRSPSKERE RRQSRSSSEE RDHSRSRSPN
KQSGYSRPRA SSKEKAHSRS RTPSKEGNHS QSRTSSKESD PSQSTVPRSP DWKRSPTRTS
SLSQNRTPSK TSSHSPSTFP SGGQTLSQDD SQADATTSKA TLPGERSSSS SSKLA
