ID   SRRTA_XENLA             Reviewed;         849 AA.
AC   B1H1X4; A1L1C0;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Serrate RNA effector molecule homolog A;
DE   AltName: Full=Arsenite-resistance protein 2-A;
GN   Name=srrt-a; Synonyms=ars2-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney, and Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a mediator between the cap-binding complex (CBC) and
CC       the primary microRNAs (miRNAs) processing machinery during cell
CC       proliferation. Contributes to the stability and delivery of capped
CC       primary miRNA transcripts to the primary miRNA processing complex,
CC       thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts ncbp1/cbp80. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm
CC       {ECO:0000250}. Note=Predominantly nuclear. Shuttles between the nucleus
CC       and the cytoplasm (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ARS2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI28977.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR   EMBL; BC128976; AAI28977.1; ALT_SEQ; mRNA.
DR   EMBL; BC160771; AAI60771.1; -; mRNA.
DR   RefSeq; NP_001116168.1; NM_001122696.1.
DR   AlphaFoldDB; B1H1X4; -.
DR   SMR; B1H1X4; -.
DR   GeneID; 100037061; -.
DR   KEGG; xla:100037061; -.
DR   CTD; 100037061; -.
DR   Xenbase; XB-GENE-6255528; srrt.S.
DR   OrthoDB; 525905at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 100037061; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   GO; GO:0031053; P:primary miRNA processing; ISS:UniProtKB.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR039727; SE/Ars2.
DR   InterPro; IPR007042; SERRATE/Ars2_C.
DR   InterPro; IPR021933; SERRATE/Ars2_N.
DR   PANTHER; PTHR13165; PTHR13165; 1.
DR   Pfam; PF04959; ARS2; 1.
DR   Pfam; PF12066; SERRATE_Ars2_N; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-mediated gene silencing.
FT   CHAIN           1..849
FT                   /note="Serrate RNA effector molecule homolog A"
FT                   /id="PRO_0000385212"
FT   REGION          1..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          276..409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        276..368
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        381..408
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   849 AA;  98581 MW;  2A4BAABC11AD7501 CRC64;
     MADSDDEYDR RRRDKFRRER SDYDRSRERE ERRRDDWSDR EWDRGRERRS RGEYRDYESR
     SRRERFSPQR HDLSPPQKRM RRDWDDHGSD PYHSGYDLPY SSSAGGPGYG PPQPWGHPEM
     HVLQHHGIPI QARLGNLHQV DLGTPAPIMK TFKEFLLSLE DTVDETEAVK RYNDYKIDFR
     RQQMQEFFLA HKDEEWFRSK YHPDEVGKHK QESQASLRNR LSAFMFLMEK SWLNEVQLDI
     AQSPAIIKVL DAAVIKMEGG TEIDLKILDE EEEEAKREAA KKEEAPVTET EKVVTEEKEA
     PAKPENDKED ESEEKPVKPQ EEEEKKVEKK VEKEEPERET RKPGTRKRKR SGESDDGSDS
     ESDTETASPK PKAETPNQNG RAEETPKKEE DTEKQKEKQK EDTVKPRPLH KTCSIFMRNI
     PPNISKAEIT ALCKRYPGFM RVALSEPQPE RRFLRKAYVT FDRSVNIKEI CWSVQNIRLR
     ECELSPGVNR DLTYRVRNIN GITLHRPIVR NDIKLAARLI HALDERAVLW EGEQMVLAQN
     PILKNITDYL IDEVNAEEEE LLFSAGRTPE TELPKDGNPT EISVERDDKL IKVLDKLLFY
     LRIVHSVDYY NTCEYPNEDE MPTRCGMMHV RGPLPPNRVS HGEVAEWQKT FEEKLAPLFA
     VRETLSEEES IKMGKKDPEQ EVEKFVAANT QELGKEKWLC PLSGKKFKGP EFVRKHIFNK
     HAEKIEEVKK EVVFFNNYLI DSKRPALLEV KPLQPPVGAA GQALAAGLLY PHQGPPALLP
     YAQPRPPVLG YGGAPQFPPN PYGAGRGNYD AFRGQGMYPG KPRNRMMRGD PRSIIEYRDL
     DAPDDVDFF