ID   SRRT_AEDAE              Reviewed;         937 AA.
AC   Q17FR9; Q17FS0;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Serrate RNA effector molecule homolog;
DE   AltName: Full=Arsenite-resistance protein 2 homolog;
GN   Name=Ars2; ORFNames=AAEL003287;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Acts as a mediator between the cap-binding complex (CBC) and
CC       RNA-mediated gene silencing (RNAi). Involved in innate immunity via the
CC       short interfering RNAs (siRNAs) processing machinery by restricting the
CC       viral RNA production. Also involved microRNA (miRNA)-mediated silencing
CC       by contributing to the stability and delivery of primary miRNA
CC       transcripts to the primary miRNA processing complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ARS2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAT45432.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH477268; EAT45431.1; -; Genomic_DNA.
DR   EMBL; CH477268; EAT45432.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001663544.1; XM_001663494.1.
DR   RefSeq; XP_001663545.1; XM_001663495.1.
DR   AlphaFoldDB; Q17FR9; -.
DR   SMR; Q17FR9; -.
DR   STRING; 7159.AAEL003287-PA; -.
DR   PRIDE; Q17FR9; -.
DR   GeneID; 5577779; -.
DR   KEGG; aag:5577779; -.
DR   VEuPathDB; VectorBase:AAEL003287; -.
DR   eggNOG; KOG2295; Eukaryota.
DR   InParanoid; Q17FR9; -.
DR   OMA; HLRMCEE; -.
DR   OrthoDB; 525905at2759; -.
DR   PhylomeDB; Q17FR9; -.
DR   Proteomes; UP000008820; Chromosome 3.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   GO; GO:0031053; P:primary miRNA processing; ISS:UniProtKB.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR039727; SE/Ars2.
DR   InterPro; IPR007042; SERRATE/Ars2_C.
DR   InterPro; IPR021933; SERRATE/Ars2_N.
DR   PANTHER; PTHR13165; PTHR13165; 1.
DR   Pfam; PF04959; ARS2; 1.
DR   Pfam; PF12066; SERRATE_Ars2_N; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; RNA-mediated gene silencing.
FT   CHAIN           1..937
FT                   /note="Serrate RNA effector molecule homolog"
FT                   /id="PRO_0000385214"
FT   REGION          1..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          109..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          293..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          847..874
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..63
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..87
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        293..367
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        381..396
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        403..498
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   937 AA;  107294 MW;  917BE908B263DF3B CRC64;
     MGDSDDEYDR KRRDKFRGER SAGESYARGA DRADRSRGRD EWAERGRPRQ DYRDYRPPPR
     DRGYSPTREG PPMKRMRGDG WGDDARPRFG GHEPYGMYGG YNHDHFGMHP AGPYGHPGGL
     HPREQQSAGD MQTQPCMMTL KQFLATQDDS ISDSEAIQKY NDYKLEFKRQ QLNEFFVAHK
     DEEWFKMKYH PEESLKRKEE QFGFLKRRCD VFVELLDHGD ISKVSVDTSN TDPLLRLLDT
     VVIKLEGGTD EDLKVLDEKP VEIVKILPEK PKVEVKKEPT LEDTIKKEKI SIKEEKVEEA
     DKPKEEKDDD KEKPAAEGEE PEGEKNDAEK EVTAEREDMD AEPAAKEPEP EEEPSRKKDR
     RKRSRSDSGS SSSSSSSSSS SDSEDEKEKE KEDKEEEEEK KETEEEAAPK SPKPVEEGEK
     EPQEEVENNG HKSGDEEEAT KKDQAEPEKM DTDEAVVENN KESEEAEKEK DTSKDEEEAN
     KESNEDKQES EKTETIDLVK DTTVGNSPRA LHRTSSIFLR NLAPSITKAE VEAMCKRYNG
     FLRVAIADPL LERRWFRRGW VTFRRDVNIK EICWNLNNIR LRDCELGAIV NKDLSRRVRP
     VNGLTCHKTI VRSDIKLCAK IAHNLDDKVG LWKEQEDNGE KNGESFGLQS KNPVLQNITD
     YLIEEASAEE DELLGLSTEA AKKSNDGELV ERDTQLIEVL DKLILYLRVV HSIDFYNHCE
     YPYEDEMPNR CGIIHARGPP PQNKVTSNEI QEYIRTFEGK MGSFLARAVD LEEEEMKKLG
     AKDAEAEVEK FIQANTQELA KDKWLCPLSG KKFKGPDFVR KHIFNKHNEK VDEVRKEVEY
     FNNYLKDTKR PQLPEHPGNT KKAPSDAAPP TAGYRPPYGM AHAYAPMYAP YAQPMMAPAG
     RARPGFGRGG REPMGEIRRP IIAYSDLDMP NFSDSFL