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SRRT_ANOGA
ID   SRRT_ANOGA              Reviewed;         967 AA.
AC   Q5TUF1;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 3.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Serrate RNA effector molecule homolog;
DE   AltName: Full=Arsenite-resistance protein 2 homolog;
GN   Name=Ars2; ORFNames=AGAP010382;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Acts as a mediator between the cap-binding complex (CBC) and
CC       RNA-mediated gene silencing (RNAi). Involved in innate immunity via the
CC       short interfering RNAs (siRNAs) processing machinery by restricting the
CC       viral RNA production. Also involved microRNA (miRNA)-mediated silencing
CC       by contributing to the stability and delivery of primary miRNA
CC       transcripts to the primary miRNA processing complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ARS2 family. {ECO:0000305}.
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DR   EMBL; AAAB01008849; EAL41034.3; -; Genomic_DNA.
DR   RefSeq; XP_559074.3; XM_559074.3.
DR   AlphaFoldDB; Q5TUF1; -.
DR   SMR; Q5TUF1; -.
DR   STRING; 7165.AGAP010382-PA; -.
DR   PaxDb; Q5TUF1; -.
DR   PRIDE; Q5TUF1; -.
DR   GeneID; 1272662; -.
DR   KEGG; aga:AgaP_AGAP010382; -.
DR   CTD; 1272662; -.
DR   VEuPathDB; VectorBase:AGAP010382; -.
DR   eggNOG; KOG2295; Eukaryota.
DR   HOGENOM; CLU_008560_0_0_1; -.
DR   InParanoid; Q5TUF1; -.
DR   OMA; HLRMCEE; -.
DR   OrthoDB; 525905at2759; -.
DR   PhylomeDB; Q5TUF1; -.
DR   Proteomes; UP000007062; Chromosome 3L.
DR   GO; GO:0016604; C:nuclear body; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   GO; GO:0031053; P:primary miRNA processing; ISS:UniProtKB.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR039727; SE/Ars2.
DR   InterPro; IPR007042; SERRATE/Ars2_C.
DR   InterPro; IPR021933; SERRATE/Ars2_N.
DR   PANTHER; PTHR13165; PTHR13165; 1.
DR   Pfam; PF04959; ARS2; 1.
DR   Pfam; PF12066; SERRATE_Ars2_N; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; RNA-mediated gene silencing.
FT   CHAIN           1..967
FT                   /note="Serrate RNA effector molecule homolog"
FT                   /id="PRO_0000385215"
FT   REGION          1..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          296..518
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          645..669
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          868..893
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..66
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        322..380
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        394..517
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   967 AA;  109612 MW;  38C31455B7A5F8CC CRC64;
     MGDSDDEYDR KRRDKFRGER SAGGGGDSYG RGADRPDRSR GRDDWPDRVR PRQDYRDYRP
     PPRDRGYSPA REGPTVKRMR GDTWGDEGRH RFGAHDGYGM YGYAHDHFGM HPTVGPYGHQ
     HATHQREPVV SGDMQTQPCM MTLKQFLATQ DDSISDSDAI TKYNEYKLEF RRQQMNEFFV
     AHKDEEWFKI KYHPEESQKR KEEQLSFLKR RCEVFLELLK SKEIGKVSVD ASNTDALLRL
     LDTVVIKLEG GTEEDLKVLD IKPSVVEAAA RTPATLNEEK VKTESKVDAT AKELAVKMEE
     DSSKQETETD VLSVPQSEED ARNGNSKIKE ELSKSMDDGN ENGDKSKSND AQKSEKEIAE
     VEHEAHKHES EDRKKRSRSD SGSSSSSSSS SSSSESEEEK DERMNKEDNE DEENMRIPEE
     EKKSDSADTM DNINRDKEVD EGKPVCDAED LNTADDRDDN ADQNKEQNEF EETTKDKNSS
     DPVNDENKEN SDKKSQQEGD SKAETIDLAK DPADGGSRAL HRTSSIFLRN LAPSITKAEV
     EAMCRRYNGF LRVAIADPLL ERRWFRRGWV TFKREVNIKE ICWNLNNIRL RDCELGAIVN
     KDLSRRVRPV NGITCHKTVV RSDIKLGAKI AHNLDDKWGL WKETPTAASG TGEAGDKNGS
     EVQPEESFGL QSKNPVLQNI TDYLIEEASA EEEELLGLSE DSKKVSEGEL IERDPQLIEV
     LDRLILYLRI VHSVDFYNHC EYPYEDEMPN RCGIIHARGP PSQSKVMSNE IQEYIRTFEG
     KMASFLTRMV DIDETDMKKL GAKDAEAEVE KFITANTQEL AKDKWLCPLS GKKFKGPDFV
     RKHIFNKHAE KVEEVRKEVE YFNNYLKDSK RPQLPEHPGN AKKPGSEGAT SATANASVGA
     GGYRNQPFGM SHSYAPMYAS YAAASMMAPN PRGRAGFGRG GRMGGPDYRP VIHYRDLDAP
     REPDEFL
 
 
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