SRRT_CAEEL
ID SRRT_CAEEL Reviewed; 712 AA.
AC Q966L5; Q86S87;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Serrate RNA effector molecule homolog;
DE AltName: Full=Arsenite-resistance protein 2 homolog;
GN ORFNames=E01A2.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING
RP (ISOFORMS A AND B).
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Acts as a mediator between the cap-binding complex (CBC) and
CC the primary microRNAs (miRNAs) processing machinery. Contributes to the
CC stability and delivery of capped primary miRNA transcripts to the
CC primary miRNA processing complex, thereby playing a role in RNA-
CC mediated gene silencing (RNAi) by miRNAs (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q966L5-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q966L5-2; Sequence=VSP_038124;
CC -!- SIMILARITY: Belongs to the ARS2 family. {ECO:0000305}.
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DR EMBL; FO081024; CCD68572.1; -; Genomic_DNA.
DR EMBL; FO081024; CCD68573.1; -; Genomic_DNA.
DR RefSeq; NP_491302.1; NM_058901.4. [Q966L5-1]
DR RefSeq; NP_871855.1; NM_182055.3.
DR AlphaFoldDB; Q966L5; -.
DR SMR; Q966L5; -.
DR BioGRID; 37467; 7.
DR STRING; 6239.E01A2.2a.1; -.
DR iPTMnet; Q966L5; -.
DR EPD; Q966L5; -.
DR PaxDb; Q966L5; -.
DR PeptideAtlas; Q966L5; -.
DR EnsemblMetazoa; E01A2.2a.1; E01A2.2a.1; WBGene00017085. [Q966L5-1]
DR EnsemblMetazoa; E01A2.2b.1; E01A2.2b.1; WBGene00017085. [Q966L5-2]
DR EnsemblMetazoa; E01A2.2b.2; E01A2.2b.2; WBGene00017085. [Q966L5-2]
DR EnsemblMetazoa; E01A2.2b.3; E01A2.2b.3; WBGene00017085. [Q966L5-2]
DR EnsemblMetazoa; E01A2.2b.4; E01A2.2b.4; WBGene00017085. [Q966L5-2]
DR GeneID; 171996; -.
DR KEGG; cel:CELE_E01A2.2; -.
DR UCSC; E01A2.2b.1; c. elegans.
DR CTD; 171996; -.
DR WormBase; E01A2.2a; CE20643; WBGene00017085; -. [Q966L5-1]
DR WormBase; E01A2.2b; CE33369; WBGene00017085; -. [Q966L5-2]
DR eggNOG; KOG2295; Eukaryota.
DR GeneTree; ENSGT00390000005492; -.
DR InParanoid; Q966L5; -.
DR OMA; FYRRGWA; -.
DR OrthoDB; 525905at2759; -.
DR PhylomeDB; Q966L5; -.
DR Reactome; R-CEL-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR PRO; PR:Q966L5; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00017085; Expressed in embryo and 4 other tissues.
DR GO; GO:0016604; C:nuclear body; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0031053; P:primary miRNA processing; ISS:UniProtKB.
DR InterPro; IPR039727; SE/Ars2.
DR InterPro; IPR007042; SERRATE/Ars2_C.
DR InterPro; IPR021933; SERRATE/Ars2_N.
DR PANTHER; PTHR13165; PTHR13165; 1.
DR Pfam; PF04959; ARS2; 1.
DR Pfam; PF12066; SERRATE_Ars2_N; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Nucleus; Reference proteome;
KW RNA-mediated gene silencing.
FT CHAIN 1..712
FT /note="Serrate RNA effector molecule homolog"
FT /id="PRO_0000220967"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..657
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..712
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..183
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_038124"
SQ SEQUENCE 712 AA; 80795 MW; 54B051AADFA547DE CRC64;
MVDSDDDGDR RRDKFARERR DEDYRRGGGG FNRYDNKRPG GRRDDYQVKR SRGDDADDSF
DPVSRSGNGS DLPTESDSIY SGPLQTFKKF LTSQEDDISE EDAIKKYNEY KTEHRKHQLE
RFFRAHKDEE WFRLKYKPDD AKKLREAHLE NVQKRLQVFN ELKEQGQFNK FSLDFGDAEA
IIRMLDSVVV KLENGTEDEL KAVLAQKLED ESLADIKKDE NGNGTEQPKE EPEVKQESGA
TEELEEGAIE DGTEKSSNKV NIHRTCSVFL RNIPPGLTYE ELEGLCKKSP GFLRLALTDG
IAERKFYRRG WATFKRDINI KEICWALNAH RLRETDLNAI INRDITRRVR TNNGIASHKQ
VAINDLKLAV KLTVLYDKKI GLFNAADEAD ADREMDIRMG VDLVAASTNP LIKEVKSLVP
HDVLNDISEE EAELLGVSNG GEAPAEKIRF ERDDNILKAL DLLIVYLRIV HSIDFYNHGH
YAQEDSMPNR CGLIHVRGQP PSGVSITTDE DGALVVPQKF VNDFISGFNS RIEKGLIEKQ
YVSEEELEKM GKKDGEKEVE AFIQKNTVEL AKDKWLCPLS GKKFKGPEFI RKHLQSKHED
KLEEARAEAD FFNNYLADAQ RPVDCEPKQA PRDDHRGGGG GERGGYGRER DDDRGPGGGG
RNSFGGGGYD RRPQFPPRHS LGGRGGGGRY FEDAPRRQPV SYRDLDAPDD IP
