ID   SRRT_DROSI              Reviewed;         947 AA.
AC   B4QCR6;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Serrate RNA effector molecule homolog;
DE   AltName: Full=Arsenite-resistance protein 2 homolog;
GN   Name=Ars2; ORFNames=GD10335;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Acts as a mediator between the cap-binding complex (CBC) and
CC       RNA-mediated gene silencing (RNAi). Involved in innate immunity via the
CC       short interfering RNAs (siRNAs) processing machinery by restricting the
CC       viral RNA production. Also involved microRNA (miRNA)-mediated silencing
CC       by contributing to the stability and delivery of primary miRNA
CC       transcripts to the primary miRNA processing complex containing drosha
CC       and pasha (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with cbp20, Dcr-2 and pasha. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ARS2 family. {ECO:0000305}.
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DR   EMBL; CM000362; EDX05855.1; -; Genomic_DNA.
DR   AlphaFoldDB; B4QCR6; -.
DR   SMR; B4QCR6; -.
DR   STRING; 7240.B4QCR6; -.
DR   HOGENOM; CLU_008560_0_0_1; -.
DR   OMA; HLRMCEE; -.
DR   PhylomeDB; B4QCR6; -.
DR   Proteomes; UP000000304; Chromosome 2r.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   GO; GO:0035194; P:post-transcriptional gene silencing by RNA; ISS:UniProtKB.
DR   GO; GO:0031053; P:primary miRNA processing; ISS:UniProtKB.
DR   InterPro; IPR039727; SE/Ars2.
DR   InterPro; IPR007042; SERRATE/Ars2_C.
DR   InterPro; IPR021933; SERRATE/Ars2_N.
DR   PANTHER; PTHR13165; PTHR13165; 1.
DR   Pfam; PF04959; ARS2; 1.
DR   Pfam; PF12066; SERRATE_Ars2_N; 1.
PE   3: Inferred from homology;
KW   Nucleus; Phosphoprotein; Reference proteome; RNA-mediated gene silencing.
FT   CHAIN           1..947
FT                   /note="Serrate RNA effector molecule homolog"
FT                   /id="PRO_0000385223"
FT   REGION          1..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          300..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          643..666
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          855..892
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..37
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..366
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        389..458
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        460..476
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        477..492
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        649..666
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        855..875
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         79
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         81
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         300
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         303
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         330
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         354
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         357
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         431
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         644
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         646
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   947 AA;  107813 MW;  E70BA8662FD244FD CRC64;
     MADSDDEYDR KRRDKFRGER DSYRTERRDD RRPVGGSAGA RDEWAERNPF RGAASAGGGG
     ARHRPDYSDY RGPGARPRYG SPGRDLPPAK RMRPDWGDGD VRANPRFGGY DPYLMQAWND
     HYQSMHSAYS HAGHAPPVRE SIGGGGSDTL TQPAMLNLKQ FLDTQDENIS DSEVMRKYTE
     YKTDFKRQQL NEFFVAHKDE EWFKNKYHPE DSVKRSEEQR GFLQRRTDVF MELFENGTIG
     SVKVDSSQAD ALIRVLDTCV IKLEGGTDED LKVLDEKPKD PVVYERKAEP MQSVKAVEKT
     INSPKDEITE ADPLPVVVST QRKPVGPVNS DEENWDDDND AENSAPKKEL AEDSKDSDSK
     PEDKQLNKKK TKKRKRNSSD DDSSSSESSS SSDEEKLKEK YDVEDGLRTE QKIEAEKDRQ
     EATKAKQEPQ SPKLDEVEGN DTTEPKGLDS KINTVEIDDT LKSPEISSNP IKNTDNGDSS
     KVEEDEEKPS VGKDNVVETE TIDLDKVKDC QPRALHRTSS IFLRNLAPSI TRSEIEAVCN
     RFNGYLRVAI ADPLVERRWY RRGWITFMRD VNIKEICWGL NNQRLRDCEM GAIVNRDLSR
     RVRPANGITA HKQVVRSDIK LCAKIALNLD EKFRLWAEVP KDDSNSARAN ESSENGSGST
     YGFNSQNPVL QNITDYLIEE ASAEEEELLG LTGENKDTEG EPIERDEQLI SVLDRLVLYL
     RIVHSVDYYN HCEYPYEDEM PNRCGIIHAR GPPPVRVTNN DVQEYIKMYE TKLQQFLTKT
     VPLSDEEIKN LGAKDAETEV EKFVQANTQE LAKDKWLCPL SGKKFKGPEF IRKHIFNKHE
     EKVDEVRKEV QYFNNYLRDP KRPQLPEHPG TSKRPESESA RGGGGGYRPP MYPPFSAMPY
     GFGPPMRGGG RAGRNFPPAR RELPLEHQRR LIGYHDLDAP ANSDMFD