SRRT_DROVI
ID SRRT_DROVI Reviewed; 963 AA.
AC B4LIK8;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Serrate RNA effector molecule homolog;
DE AltName: Full=Arsenite-resistance protein 2 homolog;
GN Name=Ars2; ORFNames=GJ20888;
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Acts as a mediator between the cap-binding complex (CBC) and
CC RNA-mediated gene silencing (RNAi). Involved in innate immunity via the
CC short interfering RNAs (siRNAs) processing machinery by restricting the
CC viral RNA production. Also involved microRNA (miRNA)-mediated silencing
CC by contributing to the stability and delivery of primary miRNA
CC transcripts to the primary miRNA processing complex containing drosha
CC and pasha (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with cbp20, Dcr-2 and pasha. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ARS2 family. {ECO:0000305}.
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DR EMBL; CH940648; EDW60378.1; -; Genomic_DNA.
DR RefSeq; XP_002049185.2; XM_002049149.2.
DR AlphaFoldDB; B4LIK8; -.
DR SMR; B4LIK8; -.
DR STRING; 7244.FBpp0235305; -.
DR GeneID; 6624841; -.
DR KEGG; dvi:6624841; -.
DR eggNOG; KOG2295; Eukaryota.
DR HOGENOM; CLU_008560_0_0_1; -.
DR InParanoid; B4LIK8; -.
DR OMA; HLRMCEE; -.
DR PhylomeDB; B4LIK8; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:EnsemblMetazoa.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0045071; P:negative regulation of viral genome replication; IEA:EnsemblMetazoa.
DR GO; GO:0035194; P:post-transcriptional gene silencing by RNA; ISS:UniProtKB.
DR GO; GO:0031053; P:primary miRNA processing; ISS:UniProtKB.
DR GO; GO:0030422; P:siRNA processing; IEA:EnsemblMetazoa.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR039727; SE/Ars2.
DR InterPro; IPR007042; SERRATE/Ars2_C.
DR InterPro; IPR021933; SERRATE/Ars2_N.
DR PANTHER; PTHR13165; PTHR13165; 1.
DR Pfam; PF04959; ARS2; 1.
DR Pfam; PF12066; SERRATE_Ars2_N; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
PE 3: Inferred from homology;
KW Nucleus; Phosphoprotein; Reference proteome; RNA-mediated gene silencing.
FT CHAIN 1..963
FT /note="Serrate RNA effector molecule homolog"
FT /id="PRO_0000385224"
FT REGION 1..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 871..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..319
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..367
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..431
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..522
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..891
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 82
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250"
FT MOD_RES 84
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 307
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 337
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 361
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 442
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 963 AA; 109044 MW; DD5616A50D8F8F3B CRC64;
MADSDDEYDR KRRDKFRGER DSYRPERRDE RRPMGGGANS RDEWSERNPF RGSSAAGGGG
GGGARHRPDY SDYRGSGPRP RYGSPGREMP PAKRMRPDWG ESEMRSNPRF GYDPYLVQAW
NDHYQSLHSA YSHSSHPSSA RESAPNVVNS DTQTQPAMLT LKQFLDTQDE NISDSEVMRK
YTEYKTDFKR QQLNEFFVAH KDEEWFKNKY HPEDSVRRSE EQRGFLKRRT DVFLELLENG
TIGSVKVDSS QADSLVRVLD TCVIKLEGGT DEDLKILDEK PKETPVVYER KSESTEASVV
AKREPESPKQ TKSEKGADEE QPVVVSPQRK SLRPVNSDEE NWDDENDEMA APAKVQGDDD
SIKSGSDKKL KKKKIKKRNR NSSDDESSSS SSFESDSDSD DEKLKAKYDV EEGLRADQKA
EAQKDKEEAA TVAKANPLPP DSPQPEGGTA LQDAAAIKSE QSDEQQEKDA EQPAELQADE
PAAAKNGEEP EKTEKNEVET KSTADDVTET IDLDKVKDGP QPRALHRTSS IFLRNLAPSI
TKAEIEAICT RFSGYLRVAI ADPLVERRWY RRGWITFTRD VNIKEICWSL NNQRLRDCEM
GAIVNRDLSR RVRPANGITA HKQIVRADIK LCAKIAMNLD ERFKLWSEAD STQQQPDAES
KPSADATNGS GGSSTTYGFN SKNPVLQNIT DYLIEEASAE EEELLGLAGD NKDGEGEPIE
RDEQLISVLD RLVLYLRIVH SVDYYNHCEY PYEDEMPNRC GIIHARGPPP MRVTSNDVQE
YIKAYDGKLQ QFLTKSVQLS DDEIKELGAK NPETEVEKFV QANTQELAKD KWLCPLSGKK
FKGPEFIRKH IFNKHEEKVD EVRKEVQYFN NYLRDPKRPQ LPEHPGSSKR TESESGRGSG
GYRPPMYPPF SAMPYGFAPP MMGGGGRGGR NFPPVRREMP LEHQRRLIGY HDLDAPVNSD
MFD
