SRRT_DROWI
ID SRRT_DROWI Reviewed; 1000 AA.
AC B4MR46;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Serrate RNA effector molecule homolog;
DE AltName: Full=Arsenite-resistance protein 2 homolog;
GN Name=Ars2; ORFNames=GK21997;
OS Drosophila willistoni (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7260;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14030-0811.24;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Acts as a mediator between the cap-binding complex (CBC) and
CC RNA-mediated gene silencing (RNAi). Involved in innate immunity via the
CC short interfering RNAs (siRNAs) processing machinery by restricting the
CC viral RNA production. Also involved microRNA (miRNA)-mediated silencing
CC by contributing to the stability and delivery of primary miRNA
CC transcripts to the primary miRNA processing complex containing drosha
CC and pasha (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with cbp20, Dcr-2 and pasha. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ARS2 family. {ECO:0000305}.
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DR EMBL; CH963849; EDW74585.1; -; Genomic_DNA.
DR RefSeq; XP_002063599.2; XM_002063563.2.
DR AlphaFoldDB; B4MR46; -.
DR SMR; B4MR46; -.
DR STRING; 7260.FBpp0251140; -.
DR PRIDE; B4MR46; -.
DR EnsemblMetazoa; FBtr0419445; FBpp0377575; FBgn0223982.
DR eggNOG; KOG2295; Eukaryota.
DR HOGENOM; CLU_008560_0_0_1; -.
DR InParanoid; B4MR46; -.
DR OMA; HLRMCEE; -.
DR OrthoDB; 525905at2759; -.
DR PhylomeDB; B4MR46; -.
DR Proteomes; UP000007798; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:EnsemblMetazoa.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0045071; P:negative regulation of viral genome replication; IEA:EnsemblMetazoa.
DR GO; GO:0035194; P:post-transcriptional gene silencing by RNA; ISS:UniProtKB.
DR GO; GO:0031053; P:primary miRNA processing; ISS:UniProtKB.
DR GO; GO:0030422; P:siRNA processing; IEA:EnsemblMetazoa.
DR InterPro; IPR039727; SE/Ars2.
DR InterPro; IPR007042; SERRATE/Ars2_C.
DR InterPro; IPR021933; SERRATE/Ars2_N.
DR PANTHER; PTHR13165; PTHR13165; 1.
DR Pfam; PF04959; ARS2; 1.
DR Pfam; PF12066; SERRATE_Ars2_N; 1.
PE 3: Inferred from homology;
KW Nucleus; Phosphoprotein; Reference proteome; RNA-mediated gene silencing.
FT CHAIN 1..1000
FT /note="Serrate RNA effector molecule homolog"
FT /id="PRO_0000385225"
FT REGION 1..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..368
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..414
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..529
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 911..927
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 83
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250"
FT MOD_RES 85
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 336
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1000 AA; 113364 MW; 3BF4F4EE095078DE CRC64;
MADSDDEYDR KRRDKFRGER SDSYRTERRD ERRPISSSGG ARDEWNPFRG SSAAGGGGGG
GARHRPDYSD YRSPGGGGPR ARYGSPGREM PPAKRMRPDW PDEGMRSNPR FGGYDPYMMQ
AWNEHYQSLH YSHGGGHMPI ARETSGPGIG NDTQTQPAML TLKQFLDTQD ENISDSEVMR
KYTEYKTDFK RQQLNEFFVA HKDEEWFKNK YHPEDSVRRS DEQRGFLQRR SSVFVELLEN
GTIGSVKVDS SQADPLVRVL DMCVIKLEGG TDEDLKILDE KPKEPLVFER KIEPIQTTAA
LAAATATPKS PKKNENDNGV AVVVSPQKND LKPVNSDEEN WETDKKSDEN DKNDNEQGDG
DKKGGESSKK QLKKKKKTKK RKRKSSDDDD DESSSSDSES SSSSEEEEDE EELKKKYDVE
DGLRTEQKAE QEKDKKEEEA IKAANVEEQP KAEEVQEKIE DEKEKVEEEP KPDVKTEAEA
VAEPDAEPKK EEEEKAKEPE DEEKKPETEE TSKMETENGE SKEETKPTPE PAVESAPAAD
VIEMETETID LDKVKDGPQP RALHRTASIF LRNLAPSITK AEIEAICNRS PGYLRVAIAD
PLVERRWYRR GWITFSRDVN IKEICWSLNN QRLRDCELGA IVNRDLSRRV RPTNGITAHK
QVVRSDIKLC AKIAMNLDER FRLWVDEPAP AADGKGETAT DATNGSSSGA TTYGFNTKNP
VLQNITDYLI EEASAEEEEL LGLSGDQNDV EGEPIVRDEQ LIAVLDRLLL YLRIVHSVDY
YNHCEYPYED EMPNRCGIIH ARGPAPMKVT SNDIQEYIKS YEGKLQQFLT KTVLLTDDDI
KDLGAKDAET EVEKFVQANT QELAKDKWLC PLSGKKFKGP EFIRKHIFNK HEEKVDEVRK
EVQFFNNYLR DPKRPQLPEH PGTTKRPEFE PSRGAGGYRP AMYPPFGGLP YGFAPPMPMG
GRGGGRGYQA RRELPLEHQR RVIGYHDLDA PANSDRENAF
