SRS12_MOUSE
ID SRS12_MOUSE Reviewed; 266 AA.
AC Q8C8K3;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Serine/arginine-rich splicing factor 12;
DE AltName: Full=Splicing factor, arginine/serine-rich 13B;
GN Name=Srsf12; Synonyms=Sfrs13b, Srrp, Srsf13b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Splicing factor that seems to antagonize SR proteins in pre-
CC mRNA splicing regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the splicing factor SR family. {ECO:0000305}.
CC -!- CAUTION: In contrast to the human ortholog, lacks the RRM (RNA
CC recognition motif) domain at the N-terminus. {ECO:0000305}.
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DR EMBL; AK046869; BAC32901.1; -; mRNA.
DR EMBL; AL670464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS18022.1; -.
DR RefSeq; NP_808442.2; NM_177774.4.
DR AlphaFoldDB; Q8C8K3; -.
DR STRING; 10090.ENSMUSP00000067939; -.
DR iPTMnet; Q8C8K3; -.
DR PhosphoSitePlus; Q8C8K3; -.
DR PaxDb; Q8C8K3; -.
DR PRIDE; Q8C8K3; -.
DR Antibodypedia; 54701; 26 antibodies from 12 providers.
DR DNASU; 272009; -.
DR Ensembl; ENSMUST00000067864; ENSMUSP00000067939; ENSMUSG00000054679.
DR GeneID; 272009; -.
DR KEGG; mmu:272009; -.
DR UCSC; uc008sft.1; mouse.
DR CTD; 135295; -.
DR MGI; MGI:2661424; Srsf12.
DR VEuPathDB; HostDB:ENSMUSG00000054679; -.
DR eggNOG; KOG0118; Eukaryota.
DR GeneTree; ENSGT00940000160519; -.
DR HOGENOM; CLU_1045709_0_0_1; -.
DR InParanoid; Q8C8K3; -.
DR OMA; LKINMPG; -.
DR OrthoDB; 1642194at2759; -.
DR PhylomeDB; Q8C8K3; -.
DR BioGRID-ORCS; 272009; 2 hits in 41 CRISPR screens.
DR PRO; PR:Q8C8K3; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8C8K3; protein.
DR Bgee; ENSMUSG00000054679; Expressed in embryonic brain and 130 other tissues.
DR ExpressionAtlas; Q8C8K3; baseline and differential.
DR Genevisible; Q8C8K3; MM.
DR GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000395; P:mRNA 5'-splice site recognition; ISO:MGI.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; ISO:MGI.
DR InterPro; IPR034477; SRSF12.
DR PANTHER; PTHR23147:SF3; PTHR23147:SF3; 1.
PE 2: Evidence at transcript level;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome.
FT CHAIN 1..266
FT /note="Serine/arginine-rich splicing factor 12"
FT /id="PRO_0000395111"
FT REGION 42..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..60
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..92
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..266
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 55
FT /note="R -> L (in Ref. 1; BAC32901)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 266 AA; 29664 MW; 96000B4B0A11722F CRC64;
MRSFSGAVWE RQVSLGAPSW PAAMGDRIYS LEARAVARSV LARPRRPRAP RPRLRLRGRP
GRGRGGLLGA GPREACLATP GPPTPPCSSG TSQTPPAPGQ MKSKERHLCS PSDHRRSRSP
SQRRSRSRSS SWGRDRRHSD SLKESRHRRS SYSQSKSRSK SLPRQSTSLR QSRTPRRNSG
SRGRSRSKSL PKRSKSMEKS QSRSPQKQTG SGAKSRPHGR HCDSIARSPC KSPRAYTSSG
SKTQTTKHSH LRSHSRSRSY HHKNSW
