SRS1A_DANRE
ID SRS1A_DANRE Reviewed; 257 AA.
AC Q7SXP4; A8E5H5;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Serine/arginine-rich splicing factor 1A;
DE AltName: Full=Splicing factor, arginine/serine-rich 1;
DE AltName: Full=Splicing factor, arginine/serine-rich 1A;
GN Name=srsf1a; Synonyms=sfrs1a, sfrs1l; ORFNames=zgc:66146;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB, and SJD; TISSUE=Egg;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in preventing exon skipping, ensuring the
CC accuracy of splicing and regulating alternative splicing.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the splicing factor SR family. {ECO:0000305}.
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DR EMBL; BX511308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC055511; AAH55511.1; -; mRNA.
DR EMBL; BC153596; AAI53597.1; -; mRNA.
DR EMBL; BC153597; AAI53598.1; -; mRNA.
DR RefSeq; NP_998180.1; NM_213015.1.
DR RefSeq; XP_005157471.1; XM_005157414.3.
DR RefSeq; XP_005157472.1; XM_005157415.3.
DR AlphaFoldDB; Q7SXP4; -.
DR SMR; Q7SXP4; -.
DR STRING; 7955.ENSDARP00000074862; -.
DR PaxDb; Q7SXP4; -.
DR Ensembl; ENSDART00000080413; ENSDARP00000074862; ENSDARG00000057691.
DR Ensembl; ENSDART00000171062; ENSDARP00000133465; ENSDARG00000111226.
DR GeneID; 406288; -.
DR KEGG; dre:406288; -.
DR CTD; 406288; -.
DR ZFIN; ZDB-GENE-040426-1950; srsf1a.
DR eggNOG; KOG0105; Eukaryota.
DR GeneTree; ENSGT00940000155585; -.
DR InParanoid; Q7SXP4; -.
DR OMA; DHSGGDR; -.
DR OrthoDB; 1321443at2759; -.
DR PhylomeDB; Q7SXP4; -.
DR TreeFam; TF106261; -.
DR PRO; PR:Q7SXP4; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 15.
DR Bgee; ENSDARG00000057691; Expressed in early embryo and 28 other tissues.
DR ExpressionAtlas; Q7SXP4; baseline.
DR GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000380; P:alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd12597; RRM1_SRSF1; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR034520; SRSF1_RRM1.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 2.
PE 2: Evidence at transcript level;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW RNA-binding.
FT CHAIN 1..257
FT /note="Serine/arginine-rich splicing factor 1A"
FT /id="PRO_0000081915"
FT DOMAIN 15..90
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 130..204
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 94..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..234
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 100
FT /note="G -> GG (in Ref. 2; AAH55511)"
FT /evidence="ECO:0000305"
FT CONFLICT 245..257
FT /note="Missing (in Ref. 2; AAH55511)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 257 AA; 28383 MW; C2E98F087566D9D9 CRC64;
MSGGVIRGPA GSNDCRIYVG NLPPDIRTKD VEDVFYKYGA IRDIDLKNRR GGPPFAFVEF
EDPRDAEDAV YARDGYDYDG YRLRVEFPRS GRGMGRGGFG GGGGGGGGGG GGGGGAPRGR
YGPPSRRSEY RVIVSGLPPS GSWQDLKDHM REAGDVCYAD VFRDGTGVVE FVRKEDMTYA
VRKLDNTKFR SHEGETAYIR VKVDGPRSPS YGRSRSRSRS RSRSRSRSNN RSRSYSPRRS
RGSPQYSPRH SRSRSRS
