ID   SRSF1_CHICK             Reviewed;         257 AA.
AC   Q5ZML3; P84170;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Serine/arginine-rich splicing factor 1;
DE   AltName: Full=Splicing factor, arginine/serine-rich 1;
GN   Name=SRSF1; Synonyms=SFRS1; ORFNames=RCJMB04_1l5;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAG31030.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB {ECO:0000312|EMBL:CAG31030.1};
RC   TISSUE=Bursa of Fabricius {ECO:0000312|EMBL:CAG31030.1};
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
RN   [2] {ECO:0000305}
RP   IDENTIFICATION, AND MASS SPECTROMETRY.
RC   TISSUE=Embryo {ECO:0000269|PubMed:16287166};
RX   PubMed=16287166; DOI=10.1002/pmic.200402056;
RA   Agudo D., Gomez-Esquer F., Diaz-Gil G., Martinez-Arribas F., Delcan J.,
RA   Schneider J., Palomar M.A., Linares R.;
RT   "Proteomic analysis of the Gallus gallus embryo at stage-29 of
RT   development.";
RL   Proteomics 5:4946-4957(2005).
CC   -!- FUNCTION: May play a role in preventing exon skipping, ensuring the
CC       accuracy of splicing and regulating alternative splicing.
CC       {ECO:0000250|UniProtKB:Q07955}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q07955}. Nucleus
CC       speckle {ECO:0000250|UniProtKB:Q07955}. Note=In nuclear speckles.
CC       Shuttles between the nucleus and the cytoplasm.
CC       {ECO:0000250|UniProtKB:Q07955}.
CC   -!- MASS SPECTROMETRY: Mass=32326; Mass_error=2; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16287166};
CC   -!- SIMILARITY: Belongs to the splicing factor SR family. {ECO:0000255}.
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DR   EMBL; AJ719371; CAG31030.1; -; mRNA.
DR   RefSeq; NP_001107213.1; NM_001113741.1.
DR   AlphaFoldDB; Q5ZML3; -.
DR   BMRB; Q5ZML3; -.
DR   SMR; Q5ZML3; -.
DR   STRING; 9031.ENSGALP00000008849; -.
DR   PaxDb; Q5ZML3; -.
DR   GeneID; 772264; -.
DR   KEGG; gga:772264; -.
DR   CTD; 6426; -.
DR   VEuPathDB; HostDB:geneid_772264; -.
DR   eggNOG; KOG0105; Eukaryota.
DR   InParanoid; Q5ZML3; -.
DR   OrthoDB; 1321443at2759; -.
DR   PhylomeDB; Q5ZML3; -.
DR   PRO; PR:Q5ZML3; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000380; P:alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   CDD; cd12597; RRM1_SRSF1; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR034520; SRSF1_RRM1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 2.
PE   1: Evidence at protein level;
KW   Acetylation; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Repeat; RNA-binding.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..257
FT                   /note="Serine/arginine-rich splicing factor 1"
FT                   /id="PRO_0000223505"
FT   DOMAIN          16..91
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          121..195
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          88..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   257 AA;  28060 MW;  7EF82AE44F9B73C8 CRC64;
     MSGGGVIRGP AGNNDCRIYV GNLPPDIRTK DIEDVFYKYG AIRDIDLKNR RGGPPFAFVE
     FEDPRDAEDA VYGRDGYDYD GYRLRVEFPR SGRGTGRGGG GGGGGGAPRG RYGPPSRRSE
     YRVIVSGLPP SGSWQDLKDH MREAGDVCYA DVFRDGTGVV EFVRKEDMTY AVRKLDNTKF
     RSHEGETAYI RVKVDGPRSP SYGRSRSRSV VVAEAVVGAT AEAAVIPQEE AEDLHATLPA
     TADPDLVHKR SLALIFL