ID   SRSF1_XENTR             Reviewed;         267 AA.
AC   Q6DII2;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Serine/arginine-rich splicing factor 1;
DE   AltName: Full=Splicing factor, arginine/serine-rich 1;
GN   Name=srsf1; Synonyms=sfrs1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in preventing exon skipping, ensuring the
CC       accuracy of splicing and regulating alternative splicing.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q07955}. Nucleus
CC       speckle {ECO:0000250|UniProtKB:Q07955}. Note=In nuclear speckles.
CC       Shuttles between the nucleus and the cytoplasm.
CC       {ECO:0000250|UniProtKB:Q07955}.
CC   -!- SIMILARITY: Belongs to the splicing factor SR family. {ECO:0000305}.
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DR   EMBL; BC075558; AAH75558.1; -; mRNA.
DR   RefSeq; NP_001006919.1; NM_001006918.1.
DR   AlphaFoldDB; Q6DII2; -.
DR   BMRB; Q6DII2; -.
DR   SMR; Q6DII2; -.
DR   PRIDE; Q6DII2; -.
DR   DNASU; 448766; -.
DR   GeneID; 448766; -.
DR   KEGG; xtr:448766; -.
DR   CTD; 6426; -.
DR   Xenbase; XB-GENE-486875; srsf1.
DR   eggNOG; KOG0105; Eukaryota.
DR   InParanoid; Q6DII2; -.
DR   OrthoDB; 1321443at2759; -.
DR   PhylomeDB; Q6DII2; -.
DR   Reactome; R-XTR-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR   Reactome; R-XTR-72163; mRNA Splicing - Major Pathway.
DR   Reactome; R-XTR-72165; mRNA Splicing - Minor Pathway.
DR   Reactome; R-XTR-72187; mRNA 3'-end processing.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000008954; Expressed in gastrula and 25 other tissues.
DR   ExpressionAtlas; Q6DII2; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000380; P:alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   CDD; cd12597; RRM1_SRSF1; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR034520; SRSF1_RRM1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Repeat; RNA-binding.
FT   CHAIN           1..267
FT                   /note="Serine/arginine-rich splicing factor 1"
FT                   /id="PRO_0000081916"
FT   DOMAIN          16..91
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          140..214
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          90..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          212..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        224..244
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..267
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   267 AA;  28832 MW;  9F58AF0CF9F88E29 CRC64;
     MSGGGVIRGP AGNNDCRIYV GNLPPDIRTK DIEDVFYKYG AIRDIDLKNR RGGPPFAFVE
     FEDPRDAEDA VYGRDGYDYD GYRLRVEFPR SGRGAGGRGG GGGGGGGGGG GGGGGGGGGG
     GGGGGAPRGR YGPPSRRSEY RVVVSGLPPS GSWQDLKDHM REAGDVCYAD VFRDGTGVVE
     FVRKEDMTYA VRKLDNTKFR SHEGETAYIR VKVDGPRSPS YGRSRSRSRS RSRSRSRSNS
     RSRSYSPRRS RGSPRYSPRH SRSRSRT