SRSF2_CHICK
ID SRSF2_CHICK Reviewed; 221 AA.
AC P30352;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Serine/arginine-rich splicing factor 2;
DE AltName: Full=Protein PR264;
DE AltName: Full=Splicing component, 35 kDa;
DE AltName: Full=Splicing factor SC35;
DE Short=SC-35;
DE AltName: Full=Splicing factor, arginine/serine-rich 2;
GN Name=SRSF2; Synonyms=SFRS2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Thymus;
RX PubMed=1557353; DOI=10.1073/pnas.89.7.2511;
RA Vellard M., Sureau A., Soret J., Martinerie C., Perbal B.;
RT "A potential splicing factor is encoded by the opposite strand of the
RT trans-spliced c-myb exon.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:2511-2515(1992).
CC -!- FUNCTION: Necessary for the splicing of pre-mRNA. It is required for
CC formation of the earliest ATP-dependent splicing complex and interacts
CC with spliceosomal components bound to both the 5'- and 3'-splice sites
CC during spliceosome assembly. It also is required for ATP-dependent
CC interactions of both U1 and U2 snRNPs with pre-mRNA.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- PTM: Extensively phosphorylated on serine residues in the RS domain.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the splicing factor SR family. {ECO:0000305}.
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DR EMBL; X62446; CAA44306.1; -; mRNA.
DR PIR; B42701; B42701.
DR RefSeq; NP_001001305.1; NM_001001305.3.
DR RefSeq; XP_015150607.1; XM_015295121.1.
DR RefSeq; XP_015150608.1; XM_015295122.1.
DR AlphaFoldDB; P30352; -.
DR BMRB; P30352; -.
DR SMR; P30352; -.
DR STRING; 9031.ENSGALP00000027988; -.
DR PRIDE; P30352; -.
DR Ensembl; ENSGALT00000028041; ENSGALP00000027988; ENSGALG00000017357.
DR Ensembl; ENSGALT00000073781; ENSGALP00000056912; ENSGALG00000017357.
DR Ensembl; ENSGALT00000107499; ENSGALP00000071757; ENSGALG00000017357.
DR GeneID; 396195; -.
DR KEGG; gga:396195; -.
DR CTD; 6427; -.
DR VEuPathDB; HostDB:geneid_396195; -.
DR eggNOG; KOG4207; Eukaryota.
DR GeneTree; ENSGT00940000154883; -.
DR HOGENOM; CLU_012062_10_3_1; -.
DR InParanoid; P30352; -.
DR OMA; PLIRCDV; -.
DR OrthoDB; 1524134at2759; -.
DR Reactome; R-GGA-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-GGA-72165; mRNA Splicing - Minor Pathway.
DR Reactome; R-GGA-72187; mRNA 3'-end processing.
DR Reactome; R-GGA-73856; RNA Polymerase II Transcription Termination.
DR PRO; PR:P30352; -.
DR Proteomes; UP000000539; Chromosome 18.
DR Bgee; ENSGALG00000017357; Expressed in spleen and 12 other tissues.
DR ExpressionAtlas; P30352; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR GO; GO:0005681; C:spliceosomal complex; IEA:Ensembl.
DR GO; GO:0036002; F:pre-mRNA binding; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:Ensembl.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR InterPro; IPR034893; SRSF2-like.
DR PANTHER; PTHR23147:SF119; PTHR23147:SF119; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00361; RRM_1; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW Reference proteome; RNA-binding.
FT CHAIN 1..221
FT /note="Serine/arginine-rich splicing factor 2"
FT /id="PRO_0000081922"
FT DOMAIN 14..92
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 91..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..187
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 221 AA; 25524 MW; 75A4D8FF9170F1BF CRC64;
MSYGRPPPDV EGMTSLKVDN LTYRTSPDTL RRVFEKYGRV GDVYIPRDRY TKESRGFAFV
RFHDKRDAED AMDAMDGAVL DGRELRVQMA RYGRPPDSHH SRRGPPPRRY GSSGYGRRSR
SPRRRRRSRS RSRSRSRSRS RSRYSRSKSR SRTRSRSRST SKSRSARRSK SKSSSVSRSR
SRSRSRSRSR SPPPTSKRES NSRSRSKSPP KSPEEEGAVS S
