ID   SRTA_STRP1              Reviewed;          46 AA.
AC   P0C0H9; Q48YZ4; Q9FDV1;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Lantibiotic streptin;
DE   Flags: Precursor;
GN   Name=srtA; OrderedLocusNames=SPy_1083, M5005_Spy0806;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- FUNCTION: Lanthionine-containing peptide antibiotic (lantibiotic)
CC       active on certain Gram-positive bacteria. The bactericidal activity of
CC       lantibiotics is based on depolarization of energized bacterial
CC       cytoplasmic membranes, initiated by the formation of aqueous
CC       transmembrane pores (By similarity). {ECO:0000250}.
CC   -!- PTM: Maturation of lantibiotics involves the enzymatic conversion of
CC       Thr, and Ser into dehydrated AA and the formation of thioether bonds
CC       with cysteine. This is followed by membrane translocation and cleavage
CC       of the modified precursor (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the type A lantibiotic family. {ECO:0000305}.
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DR   EMBL; AE004092; AAK33966.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ51424.1; -; Genomic_DNA.
DR   RefSeq; NP_269245.1; NC_002737.2.
DR   AlphaFoldDB; P0C0H9; -.
DR   STRING; 1314.HKU360_00871; -.
DR   PaxDb; P0C0H9; -.
DR   EnsemblBacteria; AAK33966; AAK33966; SPy_1083.
DR   KEGG; spy:SPy_1083; -.
DR   KEGG; spz:M5005_Spy0806; -.
DR   PATRIC; fig|160490.10.peg.938; -.
DR   HOGENOM; CLU_3189664_0_0_9; -.
DR   PHI-base; PHI:8562; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:UniProtKB-KW.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR006079; Lantibiotic_typ-A_Bacillales.
DR   TIGRFAMs; TIGR03731; lantibio_gallid; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Bacteriocin; Lantibiotic; Reference proteome.
FT   PROPEP          1..24
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000041937"
FT   PEPTIDE         25..46
FT                   /note="Lantibiotic streptin"
FT                   /id="PRO_0000041938"
SQ   SEQUENCE   46 AA;  5219 MW;  3775CC54B8A2B00F CRC64;
     MNNTIKDFDL DLKTNKKDTA TPYVGSRYLC TPGSCWKLVC FTTTVK