ID   SRTA_STRPY              Reviewed;          46 AA.
AC   P0C0H8; Q9FDV1;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Lantibiotic streptin;
DE   Flags: Precursor;
GN   Name=srtA;
OS   Streptococcus pyogenes.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BL-T;
RX   PubMed=11328600; DOI=10.1093/oxfordjournals.jbchem.a002918;
RA   Karaya K., Shimizu T., Taketo A.;
RT   "New gene cluster for lantibiotic streptin possibly involved in
RT   streptolysin S formation.";
RL   J. Biochem. 129:769-775(2001).
RN   [2]
RP   PROTEIN SEQUENCE OF 21-29, AND CHARACTERIZATION OF ANTIBIOTIC ACTIVITY.
RC   STRAIN=M25;
RX   PubMed=12732544; DOI=10.1128/aem.69.5.2737-2747.2003;
RA   Wescombe P.A., Tagg J.R.;
RT   "Purification and characterization of streptin, a type A1 lantibiotic
RT   produced by Streptococcus pyogenes.";
RL   Appl. Environ. Microbiol. 69:2737-2747(2003).
CC   -!- FUNCTION: Lanthionine-containing peptide antibiotic (lantibiotic)
CC       active on certain Gram-positive bacteria. The bactericidal activity of
CC       lantibiotics is based on depolarization of energized bacterial
CC       cytoplasmic membranes, initiated by the formation of aqueous
CC       transmembrane pores.
CC   -!- INDUCTION: Induces its own expression in at least strain M25.
CC   -!- PTM: Maturation of lantibiotics involves the enzymatic conversion of
CC       Thr, and Ser into dehydrated AA and the formation of thioether bonds
CC       with cysteine. This is followed by membrane translocation and cleavage
CC       of the modified precursor (By similarity). {ECO:0000250}.
CC   -!- MISCELLANEOUS: A longer form (streptin 2, with three more amino acids
CC       at the N-terminus) is probably due to incomplete processing. Other
CC       forms also exist, some of which are due to differing levels of
CC       dehydration.
CC   -!- SIMILARITY: Belongs to the type A lantibiotic family. {ECO:0000305}.
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DR   EMBL; AB030831; BAB08162.1; -; Genomic_DNA.
DR   RefSeq; WP_002984803.1; NZ_WXZK01000013.1.
DR   AlphaFoldDB; P0C0H8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:UniProtKB-KW.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR006079; Lantibiotic_typ-A_Bacillales.
DR   TIGRFAMs; TIGR03731; lantibio_gallid; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Bacteriocin; Direct protein sequencing;
KW   Lantibiotic.
FT   PROPEP          1..24
FT                   /id="PRO_0000017138"
FT   PEPTIDE         25..46
FT                   /note="Lantibiotic streptin"
FT                   /id="PRO_0000017139"
SQ   SEQUENCE   46 AA;  5219 MW;  3775CC54B8A2B00F CRC64;
     MNNTIKDFDL DLKTNKKDTA TPYVGSRYLC TPGSCWKLVC FTTTVK