SRTD1_HUMAN
ID SRTD1_HUMAN Reviewed; 236 AA.
AC Q9UHV2; Q9BUE7;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=SERTA domain-containing protein 1;
DE AltName: Full=CDK4-binding protein p34SEI1;
DE Short=SEI-1;
DE Short=p34(SEI-1);
DE AltName: Full=Transcriptional regulator interacting with the PHD-bromodomain 1;
DE Short=TRIP-Br1;
GN Name=SERTAD1; Synonyms=SEI1, TRIPBR1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CDK4, AND VARIANT ALA-31.
RX PubMed=10580009; DOI=10.1101/gad.13.22.3027;
RA Sugimoto M., Nakamura T., Ohtani N., Hampson L., Hampson I.N.,
RA Shimamoto A., Furuichi Y., Okumura K., Niwa S., Taya Y., Hara E.;
RT "Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1).";
RL Genes Dev. 13:3027-3033(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH E2F1 AND TFDP1, DEVELOPMENTAL
RP STAGE, AND VARIANT ALA-31.
RX PubMed=11331592; DOI=10.1093/emboj/20.9.2273;
RA Hsu S.-I., Yang C.M., Sim K.G., Hentschel D.M., O'Leary E., Bonventre J.V.;
RT "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting
RT proteins that regulate the transcriptional activity of E2F-1/DP-1.";
RL EMBO J. 20:2273-2285(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ALA-31.
RG NIEHS SNPs program;
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP DEVELOPMENTAL STAGE, AND UBIQUITINATION.
RX PubMed=18316374; DOI=10.1074/jbc.m708365200;
RA Cheong J.K., Gunaratnam L., Hsu S.I.;
RT "CRM1-mediated nuclear export is required for 26 S proteasome-dependent
RT degradation of the TRIP-Br2 proto-oncoprotein.";
RL J. Biol. Chem. 283:11661-11676(2008).
CC -!- FUNCTION: Acts at E2F-responsive promoters as coregulator to integrate
CC signals provided by PHD- and/or bromodomain-containing transcription
CC factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the
CC activity of cyclin D1/CDK4 resistant to the inhibitory effects of
CC CDKN2A/p16INK4A.
CC -!- SUBUNIT: Interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B and
CC p300/CBP. Interacts with E2F1 and TFDP1; modulates transactivation
CC activity of TFDP1/E2F complexes. Also interacts with CDK4.
CC {ECO:0000269|PubMed:10580009, ECO:0000269|PubMed:11331592}.
CC -!- INTERACTION:
CC Q9UHV2; O94817: ATG12; NbExp=3; IntAct=EBI-748601, EBI-746742;
CC Q9UHV2; Q9H503-2: BANF2; NbExp=3; IntAct=EBI-748601, EBI-11977289;
CC Q9UHV2; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-748601, EBI-8643161;
CC Q9UHV2; Q13111: CHAF1A; NbExp=3; IntAct=EBI-748601, EBI-1020839;
CC Q9UHV2; Q96Q77: CIB3; NbExp=3; IntAct=EBI-748601, EBI-10292696;
CC Q9UHV2; Q9BW66: CINP; NbExp=3; IntAct=EBI-748601, EBI-739784;
CC Q9UHV2; P61024: CKS1B; NbExp=3; IntAct=EBI-748601, EBI-456371;
CC Q9UHV2; Q6NZ36-4: FAAP20; NbExp=3; IntAct=EBI-748601, EBI-12013806;
CC Q9UHV2; Q9BVV2: FNDC11; NbExp=3; IntAct=EBI-748601, EBI-744935;
CC Q9UHV2; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-748601, EBI-748515;
CC Q9UHV2; P42858: HTT; NbExp=3; IntAct=EBI-748601, EBI-466029;
CC Q9UHV2; Q9H8E8: KAT14; NbExp=3; IntAct=EBI-748601, EBI-750907;
CC Q9UHV2; Q9NSK0: KLC4; NbExp=3; IntAct=EBI-748601, EBI-949319;
CC Q9UHV2; Q9P2K6: KLHL42; NbExp=4; IntAct=EBI-748601, EBI-739890;
CC Q9UHV2; Q9BYU1: PBX4; NbExp=3; IntAct=EBI-748601, EBI-10302990;
CC Q9UHV2; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-748601, EBI-79165;
CC Q9UHV2; Q8WWB5: PIH1D2; NbExp=3; IntAct=EBI-748601, EBI-10232538;
CC Q9UHV2; Q99633: PRPF18; NbExp=3; IntAct=EBI-748601, EBI-2798416;
CC Q9UHV2; Q9UIG4: PSORS1C2; NbExp=3; IntAct=EBI-748601, EBI-11974061;
CC Q9UHV2; Q9UDX3: SEC14L4; NbExp=3; IntAct=EBI-748601, EBI-10320311;
CC Q9UHV2; Q8WTS6: SETD7; NbExp=2; IntAct=EBI-748601, EBI-1268586;
CC Q9UHV2; Q7RTT5: SSX7; NbExp=3; IntAct=EBI-748601, EBI-12879730;
CC Q9UHV2; Q86VK4-3: ZNF410; NbExp=3; IntAct=EBI-748601, EBI-11741890;
CC Q9UHV2; PRO_0000449633 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-748601, EBI-25492395;
CC -!- DEVELOPMENTAL STAGE: Transcript levels remain constant in all phases of
CC the cell cycle. In contrast, protein levels accumulate at the G1/S
CC phase boundary and decrease progressively through S phase until G2/M
CC phase is reached. {ECO:0000269|PubMed:11331592,
CC ECO:0000269|PubMed:18316374}.
CC -!- PTM: Polyubiquitinated, which promotes proteasomal degradation.
CC {ECO:0000269|PubMed:18316374}.
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/sei1/";
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DR EMBL; AF117959; AAF08349.1; -; mRNA.
DR EMBL; AF366402; AAK52831.1; -; mRNA.
DR EMBL; AY130860; AAM77800.1; -; Genomic_DNA.
DR EMBL; BC002670; AAH02670.1; -; mRNA.
DR CCDS; CCDS12557.1; -.
DR RefSeq; NP_037508.2; NM_013376.3.
DR AlphaFoldDB; Q9UHV2; -.
DR BioGRID; 118987; 73.
DR CORUM; Q9UHV2; -.
DR IntAct; Q9UHV2; 68.
DR MINT; Q9UHV2; -.
DR STRING; 9606.ENSP00000350633; -.
DR BioMuta; SERTAD1; -.
DR DMDM; 67477469; -.
DR EPD; Q9UHV2; -.
DR MassIVE; Q9UHV2; -.
DR PaxDb; Q9UHV2; -.
DR PeptideAtlas; Q9UHV2; -.
DR PRIDE; Q9UHV2; -.
DR Antibodypedia; 16970; 193 antibodies from 31 providers.
DR DNASU; 29950; -.
DR Ensembl; ENST00000357949.5; ENSP00000350633.4; ENSG00000197019.5.
DR GeneID; 29950; -.
DR KEGG; hsa:29950; -.
DR MANE-Select; ENST00000357949.5; ENSP00000350633.4; NM_013376.4; NP_037508.2.
DR UCSC; uc002ont.6; human.
DR CTD; 29950; -.
DR DisGeNET; 29950; -.
DR GeneCards; SERTAD1; -.
DR HGNC; HGNC:17932; SERTAD1.
DR HPA; ENSG00000197019; Low tissue specificity.
DR MIM; 617850; gene.
DR neXtProt; NX_Q9UHV2; -.
DR OpenTargets; ENSG00000197019; -.
DR PharmGKB; PA134957023; -.
DR VEuPathDB; HostDB:ENSG00000197019; -.
DR eggNOG; ENOG502S52T; Eukaryota.
DR GeneTree; ENSGT00940000154733; -.
DR HOGENOM; CLU_1229598_0_0_1; -.
DR InParanoid; Q9UHV2; -.
DR OMA; LAVDTWW; -.
DR OrthoDB; 1466590at2759; -.
DR PhylomeDB; Q9UHV2; -.
DR TreeFam; TF101069; -.
DR PathwayCommons; Q9UHV2; -.
DR SignaLink; Q9UHV2; -.
DR BioGRID-ORCS; 29950; 13 hits in 1085 CRISPR screens.
DR ChiTaRS; SERTAD1; human.
DR GeneWiki; SERTAD1; -.
DR GenomeRNAi; 29950; -.
DR Pharos; Q9UHV2; Tbio.
DR PRO; PR:Q9UHV2; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9UHV2; protein.
DR Bgee; ENSG00000197019; Expressed in vena cava and 179 other tissues.
DR ExpressionAtlas; Q9UHV2; baseline and differential.
DR Genevisible; Q9UHV2; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016528; C:sarcoplasm; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; TAS:ProtInc.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; TAS:ProtInc.
DR InterPro; IPR009263; SERTA_dom.
DR Pfam; PF06031; SERTA; 1.
DR PROSITE; PS51053; SERTA; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Transcription; Transcription regulation;
KW Ubl conjugation.
FT CHAIN 1..236
FT /note="SERTA domain-containing protein 1"
FT /id="PRO_0000191611"
FT DOMAIN 38..85
FT /note="SERTA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00396"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 31
FT /note="T -> A (in dbSNP:rs268687)"
FT /evidence="ECO:0000269|PubMed:10580009,
FT ECO:0000269|PubMed:11331592, ECO:0000269|Ref.3"
FT /id="VAR_015881"
SQ SEQUENCE 236 AA; 24704 MW; 8659505783FBF50B CRC64;
MLSKGLKRKR EEEEEKEPLA VDSWWLDPGH TAVAQAPPAV ASSSLFDLSV LKLHHSLQQS
EPDLRHLVLV VNTLRRIQAS MAPAAALPPV PSPPAAPSVA DNLLASSDAA LSASMASLLE
DLSHIEGLSQ APQPLADEGP PGRSIGGAAP SLGALDLLGP ATGCLLDDGL EGLFEDIDTS
MYDNELWAPA SEGLKPGPED GPGKEEAPEL DEAELDYLMD VLVGTQALER PPGPGR
