SRTD3_HUMAN
ID SRTD3_HUMAN Reviewed; 196 AA.
AC Q9UJW9; B3KQB3; Q96CQ2;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=SERTA domain-containing protein 3;
DE AltName: Full=Replication protein-binding trans-activator;
DE Short=RPA-binding trans-activator;
GN Name=SERTAD3; Synonyms=RBT1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION
RP WITH RPA2.
RX PubMed=10982866; DOI=10.1093/nar/28.18.3478;
RA Cho J.M., Song D.J., Bergeron J., Benlimame N., Wold M.S.,
RA Alaoui-Jamali M.A.;
RT "RBT1, a novel transcriptional co-activator, binds the second subunit of
RT replication protein A.";
RL Nucleic Acids Res. 28:3478-3485(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Strong transcriptional coactivator.
CC {ECO:0000269|PubMed:10982866}.
CC -!- SUBUNIT: Interacts with RPA2. {ECO:0000269|PubMed:10982866}.
CC -!- INTERACTION:
CC Q9UJW9; X5D778: ANKRD11; NbExp=3; IntAct=EBI-748621, EBI-17183751;
CC Q9UJW9; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-748621, EBI-745073;
CC Q9UJW9; Q13515: BFSP2; NbExp=3; IntAct=EBI-748621, EBI-10229433;
CC Q9UJW9; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-748621, EBI-747505;
CC Q9UJW9; P24863: CCNC; NbExp=3; IntAct=EBI-748621, EBI-395261;
CC Q9UJW9; Q6IPU0: CENPP; NbExp=3; IntAct=EBI-748621, EBI-10250303;
CC Q9UJW9; Q96LK0: CEP19; NbExp=3; IntAct=EBI-748621, EBI-741885;
CC Q9UJW9; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-748621, EBI-11962928;
CC Q9UJW9; Q9UBT7: CTNNAL1; NbExp=3; IntAct=EBI-748621, EBI-514206;
CC Q9UJW9; Q9UER7: DAXX; NbExp=3; IntAct=EBI-748621, EBI-77321;
CC Q9UJW9; Q6W0C5: DPPA3; NbExp=3; IntAct=EBI-748621, EBI-12082590;
CC Q9UJW9; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-748621, EBI-744099;
CC Q9UJW9; Q6NZ36-4: FAAP20; NbExp=3; IntAct=EBI-748621, EBI-12013806;
CC Q9UJW9; Q9H4M3: FBXO44; NbExp=3; IntAct=EBI-748621, EBI-2322644;
CC Q9UJW9; O94868-3: FCHSD2; NbExp=3; IntAct=EBI-748621, EBI-11958845;
CC Q9UJW9; Q969Y2: GTPBP3; NbExp=3; IntAct=EBI-748621, EBI-740290;
CC Q9UJW9; Q9Y5R4: HEMK1; NbExp=3; IntAct=EBI-748621, EBI-10329202;
CC Q9UJW9; O14964: HGS; NbExp=3; IntAct=EBI-748621, EBI-740220;
CC Q9UJW9; Q14005-2: IL16; NbExp=3; IntAct=EBI-748621, EBI-17178971;
CC Q9UJW9; Q9NV31: IMP3; NbExp=3; IntAct=EBI-748621, EBI-747481;
CC Q9UJW9; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-748621, EBI-2556193;
CC Q9UJW9; Q9P2K6: KLHL42; NbExp=3; IntAct=EBI-748621, EBI-739890;
CC Q9UJW9; P52292: KPNA2; NbExp=4; IntAct=EBI-748621, EBI-349938;
CC Q9UJW9; O95983-2: MBD3; NbExp=3; IntAct=EBI-748621, EBI-11978579;
CC Q9UJW9; Q71SY5: MED25; NbExp=3; IntAct=EBI-748621, EBI-394558;
CC Q9UJW9; A6NI15: MSGN1; NbExp=3; IntAct=EBI-748621, EBI-11991020;
CC Q9UJW9; P16860: NPPB; NbExp=3; IntAct=EBI-748621, EBI-747044;
CC Q9UJW9; Q7Z3B4: NUP54; NbExp=3; IntAct=EBI-748621, EBI-741048;
CC Q9UJW9; Q7Z4N8: P4HA3; NbExp=3; IntAct=EBI-748621, EBI-10181968;
CC Q9UJW9; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-748621, EBI-79165;
CC Q9UJW9; Q16512: PKN1; NbExp=3; IntAct=EBI-748621, EBI-602382;
CC Q9UJW9; P54646: PRKAA2; NbExp=3; IntAct=EBI-748621, EBI-1383852;
CC Q9UJW9; P15927: RPA2; NbExp=5; IntAct=EBI-748621, EBI-621404;
CC Q9UJW9; Q14D33: RTP5; NbExp=3; IntAct=EBI-748621, EBI-10217913;
CC Q9UJW9; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-748621, EBI-358489;
CC Q9UJW9; P14678-2: SNRPB; NbExp=4; IntAct=EBI-748621, EBI-372475;
CC Q9UJW9; Q96JI7: SPG11; NbExp=3; IntAct=EBI-748621, EBI-2822128;
CC Q9UJW9; Q6ZRS2-3: SRCAP; NbExp=3; IntAct=EBI-748621, EBI-12029182;
CC Q9UJW9; P51687: SUOX; NbExp=5; IntAct=EBI-748621, EBI-3921347;
CC Q9UJW9; Q5VWN6: TASOR2; NbExp=3; IntAct=EBI-748621, EBI-745958;
CC Q9UJW9; Q08117-2: TLE5; NbExp=3; IntAct=EBI-748621, EBI-11741437;
CC Q9UJW9; O14787-2: TNPO2; NbExp=3; IntAct=EBI-748621, EBI-12076664;
CC Q9UJW9; Q8N7U7-2: TPRX1; NbExp=3; IntAct=EBI-748621, EBI-14115717;
CC Q9UJW9; O75865-2: TRAPPC6A; NbExp=3; IntAct=EBI-748621, EBI-8451480;
CC Q9UJW9; Q9BSJ2: TUBGCP2; NbExp=3; IntAct=EBI-748621, EBI-357881;
CC Q9UJW9; P10599: TXN; NbExp=3; IntAct=EBI-748621, EBI-594644;
CC Q9UJW9; Q9BZL1: UBL5; NbExp=4; IntAct=EBI-748621, EBI-607755;
CC Q9UJW9; Q8N6Y0: USHBP1; NbExp=7; IntAct=EBI-748621, EBI-739895;
CC Q9UJW9; Q96DA0: ZG16B; NbExp=5; IntAct=EBI-748621, EBI-953824;
CC Q9UJW9; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-748621, EBI-10183064;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10982866}.
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DR EMBL; AF192529; AAF05761.1; -; mRNA.
DR EMBL; AK074604; BAG51975.1; -; mRNA.
DR EMBL; CH471126; EAW56966.1; -; Genomic_DNA.
DR EMBL; BC014061; AAH14061.1; -; mRNA.
DR EMBL; BC050643; AAH50643.1; -; mRNA.
DR CCDS; CCDS12558.1; -.
DR RefSeq; NP_037500.2; NM_013368.3.
DR RefSeq; NP_976219.1; NM_203344.2.
DR RefSeq; XP_005258889.1; XM_005258832.3.
DR RefSeq; XP_006723242.1; XM_006723179.3.
DR AlphaFoldDB; Q9UJW9; -.
DR BioGRID; 118983; 47.
DR IntAct; Q9UJW9; 68.
DR STRING; 9606.ENSP00000325414; -.
DR iPTMnet; Q9UJW9; -.
DR PhosphoSitePlus; Q9UJW9; -.
DR BioMuta; SERTAD3; -.
DR DMDM; 60415943; -.
DR EPD; Q9UJW9; -.
DR PaxDb; Q9UJW9; -.
DR PeptideAtlas; Q9UJW9; -.
DR PRIDE; Q9UJW9; -.
DR Antibodypedia; 55379; 56 antibodies from 15 providers.
DR DNASU; 29946; -.
DR Ensembl; ENST00000322354.4; ENSP00000325414.2; ENSG00000167565.13.
DR Ensembl; ENST00000392028.8; ENSP00000375882.3; ENSG00000167565.13.
DR GeneID; 29946; -.
DR KEGG; hsa:29946; -.
DR MANE-Select; ENST00000322354.4; ENSP00000325414.2; NM_203344.3; NP_976219.1.
DR UCSC; uc002onu.5; human.
DR CTD; 29946; -.
DR DisGeNET; 29946; -.
DR GeneCards; SERTAD3; -.
DR HGNC; HGNC:17931; SERTAD3.
DR HPA; ENSG00000167565; Low tissue specificity.
DR MIM; 612125; gene.
DR neXtProt; NX_Q9UJW9; -.
DR OpenTargets; ENSG00000167565; -.
DR PharmGKB; PA134941720; -.
DR VEuPathDB; HostDB:ENSG00000167565; -.
DR eggNOG; ENOG502RY30; Eukaryota.
DR GeneTree; ENSGT00940000154733; -.
DR HOGENOM; CLU_097197_0_0_1; -.
DR InParanoid; Q9UJW9; -.
DR OMA; PGPQNEV; -.
DR OrthoDB; 1462733at2759; -.
DR PhylomeDB; Q9UJW9; -.
DR TreeFam; TF101069; -.
DR PathwayCommons; Q9UJW9; -.
DR SignaLink; Q9UJW9; -.
DR BioGRID-ORCS; 29946; 15 hits in 1086 CRISPR screens.
DR GenomeRNAi; 29946; -.
DR Pharos; Q9UJW9; Tbio.
DR PRO; PR:Q9UJW9; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9UJW9; protein.
DR Bgee; ENSG00000167565; Expressed in oocyte and 152 other tissues.
DR ExpressionAtlas; Q9UJW9; baseline and differential.
DR Genevisible; Q9UJW9; HS.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0030308; P:negative regulation of cell growth; IDA:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:UniProtKB.
DR InterPro; IPR009263; SERTA_dom.
DR InterPro; IPR039585; SERTAD3.
DR PANTHER; PTHR15530; PTHR15530; 1.
DR Pfam; PF06031; SERTA; 1.
DR PROSITE; PS51053; SERTA; 1.
PE 1: Evidence at protein level;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..196
FT /note="SERTA domain-containing protein 3"
FT /id="PRO_0000191615"
FT DOMAIN 26..73
FT /note="SERTA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00396"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 2
FT /note="V -> E (in Ref. 1; AAF05761)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 196 AA; 21769 MW; 9C54AFA126F17AF1 CRC64;
MVGGLKRKHS DLEEEEERWE WSPAGLQSYQ QALLRISLDK VQRSLGPRAP SLRRHVLIHN
TLQQLQAALR LAPAPALPPE PLFLGEEDFS LSATIGSILR ELDTSMDGTE PPQNPVTPLG
LQNEVPPQPD PVFLEALSSR YLGDSGLDDF FLDIDTSAVE KEPARAPPEP PHNLFCAPGS
WEWNELDHIM EIILGS
