SRTD3_MOUSE
ID SRTD3_MOUSE Reviewed; 197 AA.
AC Q9ERC3;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=SERTA domain-containing protein 3;
DE AltName: Full=Replication protein-binding trans-activator;
DE Short=RPA-binding trans-activator;
GN Name=Sertad3; Synonyms=Rbt1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Cho J.M., Alaoui-Jamali M.A.;
RT "Cloning of mouse RBT1 cDNA.";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Strong transcriptional coactivator. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RPA2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AF317202; AAG30951.1; -; mRNA.
DR EMBL; BC034886; AAH34886.1; -; mRNA.
DR CCDS; CCDS21021.1; -.
DR RefSeq; NP_573473.1; NM_133210.2.
DR AlphaFoldDB; Q9ERC3; -.
DR BioGRID; 228408; 1.
DR STRING; 10090.ENSMUSP00000068187; -.
DR iPTMnet; Q9ERC3; -.
DR PhosphoSitePlus; Q9ERC3; -.
DR PaxDb; Q9ERC3; -.
DR PRIDE; Q9ERC3; -.
DR Antibodypedia; 55379; 56 antibodies from 15 providers.
DR DNASU; 170742; -.
DR Ensembl; ENSMUST00000068641; ENSMUSP00000068187; ENSMUSG00000055200.
DR GeneID; 170742; -.
DR KEGG; mmu:170742; -.
DR UCSC; uc009fwg.1; mouse.
DR CTD; 29946; -.
DR MGI; MGI:2180697; Sertad3.
DR VEuPathDB; HostDB:ENSMUSG00000055200; -.
DR eggNOG; ENOG502RY30; Eukaryota.
DR GeneTree; ENSGT00940000154733; -.
DR HOGENOM; CLU_097197_0_0_1; -.
DR InParanoid; Q9ERC3; -.
DR OMA; PGPQNEV; -.
DR OrthoDB; 1462733at2759; -.
DR PhylomeDB; Q9ERC3; -.
DR TreeFam; TF101069; -.
DR BioGRID-ORCS; 170742; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Sertad3; mouse.
DR PRO; PR:Q9ERC3; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9ERC3; protein.
DR Bgee; ENSMUSG00000055200; Expressed in granulocyte and 183 other tissues.
DR ExpressionAtlas; Q9ERC3; baseline and differential.
DR Genevisible; Q9ERC3; MM.
DR GO; GO:0005737; C:cytoplasm; ISA:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0030308; P:negative regulation of cell growth; ISA:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:MGI.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR InterPro; IPR009263; SERTA_dom.
DR InterPro; IPR039585; SERTAD3.
DR PANTHER; PTHR15530; PTHR15530; 1.
DR Pfam; PF06031; SERTA; 1.
DR PROSITE; PS51053; SERTA; 1.
PE 2: Evidence at transcript level;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..197
FT /note="SERTA domain-containing protein 3"
FT /id="PRO_0000191616"
FT DOMAIN 27..74
FT /note="SERTA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00396"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 197 AA; 21935 MW; CFF6FA4C0A91D7E7 CRC64;
MGGLKRKHSD LEEEEEEEKW DWSPTALRSY QQALLRISLD KVQRSLGPRA PSLRRHVLIH
NTLQQLQAAI RLAPAPALPP EPLFLGEEDF SLSTTIGSIL RELDTSMDEM EPPLNPAASS
SPQNEIVSQA DPVFLEALSS RYLGDSGLDD FFLDIDTSAV EKDVALPPPE PPHSLFCSPG
SWEWNELDHI MEIILGS
