SRTD4_HUMAN
ID SRTD4_HUMAN Reviewed; 356 AA.
AC Q9NUC0; B2RD32;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=SERTA domain-containing protein 4;
GN Name=SERTAD4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Corpus callosum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9NUC0; Q0VDC6: FKBP1A; NbExp=3; IntAct=EBI-1773811, EBI-10226858;
CC Q9NUC0; P54652: HSPA2; NbExp=3; IntAct=EBI-1773811, EBI-356991;
CC Q9NUC0; P49591: SARS1; NbExp=3; IntAct=EBI-1773811, EBI-1053431;
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DR EMBL; AK315386; BAG37779.1; -; mRNA.
DR EMBL; AL035414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471100; EAW93433.1; -; Genomic_DNA.
DR EMBL; BC012083; AAH12083.1; -; mRNA.
DR CCDS; CCDS1494.1; -.
DR RefSeq; NP_062551.1; NM_019605.3.
DR AlphaFoldDB; Q9NUC0; -.
DR BioGRID; 121121; 18.
DR IntAct; Q9NUC0; 15.
DR STRING; 9606.ENSP00000355979; -.
DR iPTMnet; Q9NUC0; -.
DR PhosphoSitePlus; Q9NUC0; -.
DR BioMuta; SERTAD4; -.
DR DMDM; 74752974; -.
DR jPOST; Q9NUC0; -.
DR MassIVE; Q9NUC0; -.
DR PaxDb; Q9NUC0; -.
DR PeptideAtlas; Q9NUC0; -.
DR PRIDE; Q9NUC0; -.
DR Antibodypedia; 34600; 95 antibodies from 19 providers.
DR DNASU; 56256; -.
DR Ensembl; ENST00000367012.4; ENSP00000355979.3; ENSG00000082497.12.
DR Ensembl; ENST00000630425.2; ENSP00000486369.1; ENSG00000281230.3.
DR GeneID; 56256; -.
DR KEGG; hsa:56256; -.
DR MANE-Select; ENST00000367012.4; ENSP00000355979.3; NM_019605.5; NP_062551.1.
DR UCSC; uc001hhy.4; human.
DR CTD; 56256; -.
DR GeneCards; SERTAD4; -.
DR HGNC; HGNC:25236; SERTAD4.
DR HPA; ENSG00000082497; Low tissue specificity.
DR neXtProt; NX_Q9NUC0; -.
DR OpenTargets; ENSG00000082497; -.
DR PharmGKB; PA134897438; -.
DR VEuPathDB; HostDB:ENSG00000082497; -.
DR eggNOG; ENOG502S9V2; Eukaryota.
DR GeneTree; ENSGT00530000063876; -.
DR HOGENOM; CLU_069835_0_0_1; -.
DR InParanoid; Q9NUC0; -.
DR OMA; CSHQVDY; -.
DR OrthoDB; 1034563at2759; -.
DR PhylomeDB; Q9NUC0; -.
DR TreeFam; TF336235; -.
DR PathwayCommons; Q9NUC0; -.
DR SignaLink; Q9NUC0; -.
DR BioGRID-ORCS; 56256; 11 hits in 1065 CRISPR screens.
DR ChiTaRS; SERTAD4; human.
DR GenomeRNAi; 56256; -.
DR Pharos; Q9NUC0; Tdark.
DR PRO; PR:Q9NUC0; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9NUC0; protein.
DR Bgee; ENSG00000082497; Expressed in calcaneal tendon and 107 other tissues.
DR Genevisible; Q9NUC0; HS.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR InterPro; IPR009263; SERTA_dom.
DR InterPro; IPR029708; SERTAD4.
DR PANTHER; PTHR14272; PTHR14272; 1.
DR Pfam; PF06031; SERTA; 1.
DR PROSITE; PS51053; SERTA; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..356
FT /note="SERTA domain-containing protein 4"
FT /id="PRO_0000314139"
FT DOMAIN 101..147
FT /note="SERTA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00396"
FT REGION 33..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 356 AA; 39348 MW; AC08F5241EFECE74 CRC64;
MTLVLSMNRF CEPIVSEGAA EIAGYQTLWE ADSYGGPSPP GPAQAPLQGD RGAGPPLAGS
HYRGISNPIT TSKITYFKRK YVEEEDFHPP LSSCSHKTIS IFEERAHILY MSLEKLKFID
DPEVYLRRSV LINNLMKRIH GEIIMQNNWC FPACSFNGTS AQEWFMAQDC PYRKRPRMAK
EECEKFHACC FYQECGGHYL NLPLSVNANV GSASTAASSP SASSSSSSSS SSPPLPLPSC
SRQVDFDVGS ASIYKSDGQI PANEIFVTNV RSLGVQEKAK LNDEKANDDT NRDGGPLSHE
PVGNDLAFEC KGQFYDYFET GYNERNNVNE SWKKSLRKKE ASPPSNKLCC SKGSKI
