ID   SRTD4_MOUSE             Reviewed;         377 AA.
AC   A7DTG3; Q6PAK2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=SERTA domain-containing protein 4;
GN   Name=Sertad4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=16546331; DOI=10.1016/j.gene.2006.01.027;
RA   Bennetts J.S., Fowles L.F., Berkman J.L., van Bueren K.L., Richman J.M.,
RA   Simpson F., Wicking C.;
RT   "Evolutionary conservation and murine embryonic expression of the gene
RT   encoding the SERTA domain-containing protein CDCA4 (HEPP).";
RL   Gene 374:153-165(2006).
CC   -!- TISSUE SPECIFICITY: Highly expressed in adult epidermal tissues and in
CC       digits. {ECO:0000269|PubMed:16546331}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH60251.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL365326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC060251; AAH60251.1; ALT_INIT; mRNA.
DR   CCDS; CCDS15630.2; -.
DR   RefSeq; NP_001171265.1; NM_001177794.1.
DR   RefSeq; NP_937890.2; NM_198247.2.
DR   RefSeq; XP_006497311.1; XM_006497248.2.
DR   AlphaFoldDB; A7DTG3; -.
DR   BioGRID; 229565; 1.
DR   IntAct; A7DTG3; 2.
DR   STRING; 10090.ENSMUSP00000116176; -.
DR   PhosphoSitePlus; A7DTG3; -.
DR   PaxDb; A7DTG3; -.
DR   PRIDE; A7DTG3; -.
DR   ProteomicsDB; 254565; -.
DR   Antibodypedia; 34600; 95 antibodies from 19 providers.
DR   Ensembl; ENSMUST00000016406; ENSMUSP00000016406; ENSMUSG00000016262.
DR   Ensembl; ENSMUST00000155579; ENSMUSP00000116176; ENSMUSG00000016262.
DR   GeneID; 214791; -.
DR   KEGG; mmu:214791; -.
DR   UCSC; uc007eds.2; mouse.
DR   CTD; 56256; -.
DR   MGI; MGI:2443496; Sertad4.
DR   VEuPathDB; HostDB:ENSMUSG00000016262; -.
DR   eggNOG; ENOG502S9V2; Eukaryota.
DR   GeneTree; ENSGT00530000063876; -.
DR   HOGENOM; CLU_069835_0_0_1; -.
DR   InParanoid; A7DTG3; -.
DR   OMA; CSHQVDY; -.
DR   OrthoDB; 1034563at2759; -.
DR   PhylomeDB; A7DTG3; -.
DR   TreeFam; TF336235; -.
DR   BioGRID-ORCS; 214791; 3 hits in 71 CRISPR screens.
DR   PRO; PR:A7DTG3; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; A7DTG3; protein.
DR   Bgee; ENSMUSG00000016262; Expressed in humerus cartilage element and 217 other tissues.
DR   ExpressionAtlas; A7DTG3; baseline and differential.
DR   Genevisible; A7DTG3; MM.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   InterPro; IPR009263; SERTA_dom.
DR   InterPro; IPR029708; SERTAD4.
DR   PANTHER; PTHR14272; PTHR14272; 1.
DR   Pfam; PF06031; SERTA; 1.
DR   PROSITE; PS51053; SERTA; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..377
FT                   /note="SERTA domain-containing protein 4"
FT                   /id="PRO_0000314140"
FT   DOMAIN          101..147
FT                   /note="SERTA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00396"
FT   REGION          36..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          221..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          306..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        1..2
FT                   /note="MT -> RP (in Ref. 2; AAH60251)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   377 AA;  41096 MW;  04AD821949D5996B CRC64;
     MTLVLSMNRF CEPIVSEGAA EIAGYQTLWE ADSYGGASPP GPAPVPSQGD RGASSHLAGS
     HYRGIPNPIS TPKVTYFKRK YAEDEDLHPP LSSCSHKTIS IFEERAHILY MSLEKLRFID
     DPEVYLRRSV LINNLMKRIH GEIVMQNSWC LPACSLGGTP AQEWFLAQDC PYRKRPRVAK
     EEWEKIHTCC FYQECGGHCL NLPLSVNTSV GSTSAAAVAS AASSSSSPST SSSSSPSSSS
     SPSPSPSSSS SSSSSSPLPL PSCSHHVDFD IGSAPIYKSQ IPASEIFVTN IRSLGVQEKV
     KFNNDGKVSH ETSRDGDALG QEPVGNDLDF ECKGQFYDYF ETGYNERNRV SESWKKSLRK
     KELSPSSKLC CNRGGKM