ID   SRTF_STRP1              Reviewed;         229 AA.
AC   P0C0E3; Q48YZ2; Q9FDU7;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Lantibiotic transport ATP-binding protein SrtF;
GN   Name=srtF; OrderedLocusNames=SPy_1085, M5005_Spy0808;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- FUNCTION: Implicated in the export process of the lantibiotic SrtA.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR   EMBL; AE004092; AAK33968.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ51426.1; -; Genomic_DNA.
DR   RefSeq; NP_269247.1; NC_002737.2.
DR   AlphaFoldDB; P0C0E3; -.
DR   SMR; P0C0E3; -.
DR   STRING; 1314.HKU360_00875; -.
DR   PaxDb; P0C0E3; -.
DR   EnsemblBacteria; AAK33968; AAK33968; SPy_1085.
DR   KEGG; spy:SPy_1085; -.
DR   KEGG; spz:M5005_Spy0808; -.
DR   PATRIC; fig|160490.10.peg.940; -.
DR   HOGENOM; CLU_000604_1_2_9; -.
DR   OMA; ICGKTKA; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProt.
DR   GO; GO:0043213; P:bacteriocin transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR022501; ABC_Gallidermin_ATP-bd.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03740; galliderm_ABC; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Bacteriocin transport; Nucleotide-binding; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..229
FT                   /note="Lantibiotic transport ATP-binding protein SrtF"
FT                   /id="PRO_0000092979"
FT   DOMAIN          2..225
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         34..41
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   229 AA;  25679 MW;  065ED5C34ACA8D07 CRC64;
     MLKIQNLKKS YGKRTILNNV NMNIPKGKVY ALIGPNGAGK STIMKILTGL VSKTSGSIIF
     EGREWSRRDL RKIGSIIEEP PLYKNLSAYD NMKVVTTMLG VSESTILPLL NKVGLGNIDK
     RPVKQFSLGM KQRLGIAISL INSPKLLILD EPTNGLDPIG IQELREIIES FKSEGMTIMI
     SSHILSEVEH LADFIGFIYE GKIILEKEYD GSENLEELFN NQILFEKRR