SRTM1_HUMAN
ID SRTM1_HUMAN Reviewed; 107 AA.
AC A2A2V5; Q8N469;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Serine-rich and transmembrane domain-containing protein 1;
GN Name=SERTM1; Synonyms=C13orf36;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC A2A2V5; P19397: CD53; NbExp=3; IntAct=EBI-17284533, EBI-6657396;
CC A2A2V5; O95471: CLDN7; NbExp=3; IntAct=EBI-17284533, EBI-740744;
CC A2A2V5; P54849: EMP1; NbExp=3; IntAct=EBI-17284533, EBI-4319440;
CC A2A2V5; P08034: GJB1; NbExp=3; IntAct=EBI-17284533, EBI-17565645;
CC A2A2V5; O15529: GPR42; NbExp=3; IntAct=EBI-17284533, EBI-18076404;
CC A2A2V5; Q8TED1: GPX8; NbExp=3; IntAct=EBI-17284533, EBI-11721746;
CC A2A2V5; P48051: KCNJ6; NbExp=3; IntAct=EBI-17284533, EBI-12017638;
CC A2A2V5; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-17284533, EBI-2820517;
CC A2A2V5; Q9HCJ2: LRRC4C; NbExp=3; IntAct=EBI-17284533, EBI-3925442;
CC A2A2V5; Q96JQ5: MS4A4A; NbExp=3; IntAct=EBI-17284533, EBI-12820341;
CC A2A2V5; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-17284533, EBI-3923617;
CC A2A2V5; Q9HBV2: SPACA1; NbExp=3; IntAct=EBI-17284533, EBI-17498703;
CC A2A2V5; Q96HH6: TMEM19; NbExp=3; IntAct=EBI-17284533, EBI-741829;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AL136160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471075; EAX08568.1; -; Genomic_DNA.
DR EMBL; BC036540; AAH36540.1; -; mRNA.
DR CCDS; CCDS9358.1; -.
DR RefSeq; NP_982276.2; NM_203451.2.
DR AlphaFoldDB; A2A2V5; -.
DR SMR; A2A2V5; -.
DR BioGRID; 134522; 14.
DR IntAct; A2A2V5; 13.
DR STRING; 9606.ENSP00000325776; -.
DR PhosphoSitePlus; A2A2V5; -.
DR BioMuta; SERTM1; -.
DR PaxDb; A2A2V5; -.
DR PeptideAtlas; A2A2V5; -.
DR PRIDE; A2A2V5; -.
DR Antibodypedia; 57544; 9 antibodies from 5 providers.
DR DNASU; 400120; -.
DR Ensembl; ENST00000315190.4; ENSP00000325776.3; ENSG00000180440.4.
DR GeneID; 400120; -.
DR KEGG; hsa:400120; -.
DR MANE-Select; ENST00000315190.4; ENSP00000325776.3; NM_203451.3; NP_982276.2.
DR UCSC; uc001uvt.5; human.
DR CTD; 400120; -.
DR GeneCards; SERTM1; -.
DR HGNC; HGNC:33792; SERTM1.
DR HPA; ENSG00000180440; Tissue enhanced (endometrium, fallopian tube).
DR neXtProt; NX_A2A2V5; -.
DR OpenTargets; ENSG00000180440; -.
DR PharmGKB; PA162378085; -.
DR VEuPathDB; HostDB:ENSG00000180440; -.
DR eggNOG; ENOG502S4A5; Eukaryota.
DR GeneTree; ENSGT00390000016881; -.
DR HOGENOM; CLU_2196038_0_0_1; -.
DR InParanoid; A2A2V5; -.
DR OMA; PGGRQGN; -.
DR OrthoDB; 1631633at2759; -.
DR PhylomeDB; A2A2V5; -.
DR TreeFam; TF338260; -.
DR PathwayCommons; A2A2V5; -.
DR SignaLink; A2A2V5; -.
DR BioGRID-ORCS; 400120; 9 hits in 1062 CRISPR screens.
DR ChiTaRS; SERTM1; human.
DR GenomeRNAi; 400120; -.
DR Pharos; A2A2V5; Tdark.
DR PRO; PR:A2A2V5; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; A2A2V5; protein.
DR Bgee; ENSG00000180440; Expressed in germinal epithelium of ovary and 114 other tissues.
DR Genevisible; A2A2V5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR InterPro; IPR031741; SERTM.
DR PANTHER; PTHR35660; PTHR35660; 1.
DR Pfam; PF15872; SRTM1; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..107
FT /note="Serine-rich and transmembrane domain-containing
FT protein 1"
FT /id="PRO_0000331521"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 78
FT /note="E -> G (in Ref. 3; AAH36540)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 107 AA; 11458 MW; B12383B9845E1501 CRC64;
MSEPDTSSGF SGSVENGTFL ELFPTSLSTS VDPSSGHLSN VYIYVSIFLS LLAFLLLLLI
IALQRLKNII SSSSSYPEYP SDAGSSFTNL EVCSISSQRS TFSNLSS
