ID   SRTXD_ATREN             Reviewed;          21 AA.
AC   P13211;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Sarafotoxin-D;
DE            Short=SRTX-D;
DE   AltName: Full=S6D;
OS   Atractaspis engaddensis (Israeli burrowing asp) (Israeli mole viper).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Lamprophiidae; Atractaspidinae; Atractaspis.
OX   NCBI_TaxID=1343144;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND TOXIC DOSE.
RC   TISSUE=Venom;
RX   PubMed=2509240; DOI=10.1016/0014-5793(89)81706-5;
RA   Bdolah A., Wollberg Z., Fleminger G.;
RT   "SRTX-d, a new native peptide of the endothelin/sarafotoxin family.";
RL   FEBS Lett. 256:1-3(1989).
CC   -!- FUNCTION: Vasoconstrictor activity. These toxins cause cardiac arrest
CC       probably as a result of coronary vasospasm. May act by displaying
CC       agonistic activities towards endothelin-1 and -2 receptors (EDNRA and
CC       EDNRB). {ECO:0000269|PubMed:2509240}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- TOXIC DOSE: LD(50) is 0.35 mg/kg by intravenous injection.
CC       {ECO:0000269|PubMed:2509240}.
CC   -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P13211; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR   GO; GO:0042310; P:vasoconstriction; IEA:UniProtKB-KW.
DR   InterPro; IPR019764; Endothelin_toxin_CS.
DR   InterPro; IPR001928; Endothln-like_toxin.
DR   Pfam; PF00322; Endothelin; 1.
DR   SMART; SM00272; END; 1.
DR   PROSITE; PS00270; ENDOTHELIN; 1.
PE   1: Evidence at protein level;
KW   Cardiotoxin; Direct protein sequencing; Disulfide bond;
KW   G-protein coupled receptor impairing toxin; Secreted; Toxin; Vasoactive;
KW   Vasoconstrictor.
FT   PEPTIDE         1..21
FT                   /note="Sarafotoxin-D"
FT                   /id="PRO_0000043644"
FT   SITE            21
FT                   /note="Endothelin-receptor binding site"
FT                   /evidence="ECO:0000250"
FT   DISULFID        1..15
FT                   /evidence="ECO:0000250"
FT   DISULFID        3..11
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   21 AA;  2596 MW;  83A8A04D1D536AE2 CRC64;
     CTCKDMTDKE CLYFCHQDII W