ID   SRX1B_SARPE             Reviewed;          63 AA.
AC   P08376;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 2.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Sarcotoxin-1B;
DE   AltName: Full=Sarcotoxin IB;
DE   Flags: Precursor;
OS   Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC   Sarcophagidae; Sarcophaga; Boettcherisca.
OX   NCBI_TaxID=7386;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2689214; DOI=10.1016/0014-5793(89)81652-7;
RA   Kanai A., Natori S.;
RT   "Cloning of gene cluster for sarcotoxin I, antibacterial proteins of
RT   Sarcophaga peregrina.";
RL   FEBS Lett. 258:199-202(1989).
RN   [2]
RP   PROTEIN SEQUENCE OF 24-62, AND AMIDATION AT ARG-62.
RX   PubMed=3888997; DOI=10.1016/s0021-9258(17)39590-x;
RA   Okada M., Natori S.;
RT   "Primary structure of sarcotoxin I, an antibacterial protein induced in the
RT   hemolymph of Sarcophaga peregrina (flesh fly) larvae.";
RL   J. Biol. Chem. 260:7174-7177(1985).
CC   -!- FUNCTION: Sarcotoxins, which are potent bactericidal proteins, are
CC       produced in response to injury. They are cytotoxic to both Gram-
CC       positive and Gram-negative bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; X17315; CAB57824.1; -; Genomic_DNA.
DR   PIR; S07048; CKFHBS.
DR   AlphaFoldDB; P08376; -.
DR   SMR; P08376; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:UniProt.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   InterPro; IPR020400; Cecropin_insect.
DR   PANTHER; PTHR38329; PTHR38329; 1.
DR   Pfam; PF00272; Cecropin; 1.
DR   PROSITE; PS00268; CECROPIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Direct protein sequencing; Immunity;
KW   Innate immunity; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:3888997"
FT   CHAIN           24..62
FT                   /note="Sarcotoxin-1B"
FT                   /id="PRO_0000004876"
FT   MOD_RES         62
FT                   /note="Arginine amide"
FT                   /evidence="ECO:0000269|PubMed:3888997"
SQ   SEQUENCE   63 AA;  6753 MW;  EA28629457E451F7 CRC64;
     MNFNKVFIFV ALILAVFAGQ SQAGWLKKIG KKIERVGQHT RDATIQVIGV AQQAANVAAT
     ARG