ID   SRX1D_SARPE             Reviewed;          40 AA.
AC   P18312;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Sarcotoxin-1D;
DE   AltName: Full=Sarcotoxin ID;
OS   Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC   Sarcophagidae; Sarcophaga; Boettcherisca.
OX   NCBI_TaxID=7386;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3182836; DOI=10.1016/s0021-9258(18)37505-7;
RA   Matsuyama K., Natori S.;
RT   "Purification of three antibacterial proteins from the culture medium of
RT   NIH-Sape-4, an embryonic cell line of Sarcophaga peregrina.";
RL   J. Biol. Chem. 263:17112-17116(1988).
CC   -!- FUNCTION: Sarcotoxins, which are potent bactericidal proteins, are
CC       produced in response to injury. They are cytotoxic to both Gram-
CC       positive and Gram-negative bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   PIR; B31791; B31791.
DR   AlphaFoldDB; P18312; -.
DR   SMR; P18312; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   Pfam; PF00272; Cecropin; 1.
DR   PROSITE; PS00268; CECROPIN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Immunity;
KW   Innate immunity; Secreted.
FT   PEPTIDE         1..40
FT                   /note="Sarcotoxin-1D"
FT                   /id="PRO_0000044686"
SQ   SEQUENCE   40 AA;  4349 MW;  E794046FD65F6D77 CRC64;
     GWIRDFGKRI ERVGQHTRDA TIQTIAVAQQ AANVAATLKG