ID   SRX21_SARPE             Reviewed;         265 AA.
AC   P24491;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Sarcotoxin II-1;
DE   Flags: Precursor;
OS   Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC   Sarcophagidae; Sarcophaga; Boettcherisca.
OX   NCBI_TaxID=7386;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2247051; DOI=10.1128/mcb.10.12.6114-6122.1990;
RA   Kanai A., Natori S.;
RT   "Analysis of a gene cluster for sarcotoxin II, a group of antibacterial
RT   proteins of Sarcophaga peregrina.";
RL   Mol. Cell. Biol. 10:6114-6122(1990).
CC   -!- FUNCTION: Sarcotoxin II is an antibacterial protein which plays a role
CC       in the inflammatory response of this insect. The main effect of
CC       sarcotoxin II on E.coli may be the inhibition of cell wall synthesis,
CC       including septum formation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Synthesized by the fat body and is eventually
CC       secreted into the hemolymph.
CC   -!- INDUCTION: In response to injury of the body wall of the larvae.
CC   -!- MISCELLANEOUS: Sarcotoxin II consists of at least four structurally
CC       related proteins named sarcotoxin IIa, II-1, II-2, and II-3.
CC   -!- SIMILARITY: Belongs to the attacin/sarcotoxin-2 family. {ECO:0000305}.
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DR   EMBL; D90154; BAA14184.1; -; Genomic_DNA.
DR   PIR; A36351; A36351.
DR   AlphaFoldDB; P24491; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR005521; Attacin_C.
DR   InterPro; IPR005520; Attacin_N.
DR   Pfam; PF03769; Attacin_C; 1.
DR   Pfam; PF03768; Attacin_N; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Antibiotic; Antimicrobial; Immunity; Innate immunity;
KW   Pyrrolidone carboxylic acid; Repeat; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   PROPEP          23..24
FT                   /note="Removed by a dipeptidylpeptidase"
FT                   /id="PRO_0000004885"
FT   CHAIN           25..264
FT                   /note="Sarcotoxin II-1"
FT                   /id="PRO_0000004886"
FT   MOD_RES         25
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         264
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   265 AA;  27471 MW;  070BD36EE787F328 CRC64;
     MKSFVLFAAC MAIIALGSLA HAYPQKLPVP IPPPSNPPVA VLQNSVATNS KGGQDVSVKL
     SATNLGNNHV QPIAEVFAEG NTKGGNVLRG ATVGVQGHGL GASVTKTQTD TKIKGLDFQP
     QLSSSTLALQ GDRLGASISR DVNRGVSDTF TKSVSANVFR NDNHNLDATV FRSDVRQNNG
     FNFQKTGGML DYSHANGHGL NAGLTHFSGI GNQANVGGSS TLFKSNDGSL SLKANAGGSQ
     WLSGPFSNQR DYNVGLSLTH HGCGG