SRX43_CAEEL
ID SRX43_CAEEL Reviewed; 319 AA.
AC O45767;
DT 15-FEB-2017, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Serpentine receptor class X-43 {ECO:0000305};
DE Short=Protein srx-43 {ECO:0000305};
GN Name=srx-43 {ECO:0000303|PubMed:27799655, ECO:0000312|WormBase:T10C6.3};
GN ORFNames=T10C6.3 {ECO:0000312|WormBase:T10C6.3};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=27893361; DOI=10.7554/elife.21454;
RA Greene J.S., Dobosiewicz M., Butcher R.A., McGrath P.T., Bargmann C.I.;
RT "Regulatory changes in two chemoreceptor genes contribute to a
RT Caenorhabditis elegans QTL for foraging behavior.";
RL Elife 5:0-0(2016).
RN [3] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=27799655; DOI=10.1038/nature19848;
RA Greene J.S., Brown M., Dobosiewicz M., Ishida I.G., Macosko E.Z., Zhang X.,
RA Butcher R.A., Cline D.J., McGrath P.T., Bargmann C.I.;
RT "Balancing selection shapes density-dependent foraging behaviour.";
RL Nature 539:254-258(2016).
CC -!- FUNCTION: Receptor for the ascaroside pheromone icas#9 which suppresses
CC exploratory forgaging behavior. In response to ascaroside icas#9, may
CC furthermore play a role in the expression of genes in the TGF-beta
CC signaling pathway, such as daf-7, and in insulin signaling pathway,
CC such as daf-28, which may in turn contribute to exploratory behavior.
CC {ECO:0000269|PubMed:27799655, ECO:0000269|PubMed:27893361}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:27799655};
CC Multi-pass membrane protein {ECO:0000255}. Perikaryon
CC {ECO:0000269|PubMed:27799655}. Cell projection, cilium
CC {ECO:0000269|PubMed:27799655}.
CC -!- TISSUE SPECIFICITY: Expressed in ASI sensory neurons.
CC {ECO:0000269|PubMed:27799655}.
CC -!- DISRUPTION PHENOTYPE: Insensitivity to ascaroside pheromones.
CC {ECO:0000269|PubMed:27893361}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; BX284605; CAB07660.2; -; Genomic_DNA.
DR PIR; T24794; T24794.
DR RefSeq; NP_507022.2; NM_074621.2.
DR AlphaFoldDB; O45767; -.
DR SMR; O45767; -.
DR STRING; 6239.T10C6.3; -.
DR PaxDb; O45767; -.
DR EnsemblMetazoa; T10C6.3.1; T10C6.3.1; WBGene00005934.
DR GeneID; 188374; -.
DR KEGG; cel:CELE_T10C6.3; -.
DR UCSC; T10C6.3; c. elegans.
DR CTD; 188374; -.
DR WormBase; T10C6.3; CE36322; WBGene00005934; srx-43.
DR eggNOG; ENOG502TH26; Eukaryota.
DR GeneTree; ENSGT00970000195834; -.
DR HOGENOM; CLU_059630_3_1_1; -.
DR InParanoid; O45767; -.
DR OMA; ILMINQN; -.
DR OrthoDB; 1392973at2759; -.
DR PhylomeDB; O45767; -.
DR PRO; PR:O45767; -.
DR Proteomes; UP000001940; Chromosome V.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0097730; C:non-motile cilium; IDA:UniProtKB.
DR GO; GO:0043204; C:perikaryon; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IMP:UniProtKB.
DR GO; GO:0019722; P:calcium-mediated signaling; IMP:UniProtKB.
DR GO; GO:0071444; P:cellular response to pheromone; IMP:UniProtKB.
DR GO; GO:0035641; P:locomotory exploration behavior; IMP:UniProtKB.
DR InterPro; IPR019430; 7TM_GPCR_serpentine_rcpt_Srx.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF10328; 7TM_GPCR_Srx; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cell projection; G-protein coupled receptor; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..319
FT /note="Serpentine receptor class X-43"
FT /evidence="ECO:0000305"
FT /id="PRO_0000438975"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
SQ SEQUENCE 319 AA; 35881 MW; 1747F0CE5CBD6A01 CRC64;
MVLRNLTAMA IYDQTFVYSS DDALAGMVVS MECLTGLFLL VAVIIGCFRI AALKSPFGIL
MINQNCAQLM ACINSGSFST LGVLLNIKPV LSISYLFGNF SIFLLPVILI SFLLMSFNRF
CACFFPLRYQ NLFSSSMIRT FIVFNWLLSL VAGSYLVVVR ECNFVFYHFG WLFAGSVSVK
CGTLLSLYSI SIQTVLSITI VGLDVVTLVA LMAFRSKVYQ SHSVEVRRRE LSFSGQVIIQ
GAVFLCHGAW YDMGHAILPG NDDRWKFFFT TSFSSNLLHV FDPVVVFAFN KEFRRWLFRN
FNVPTAQKRI VTVVSAHNT
