ID   SRX45_CAEEL             Reviewed;         361 AA.
AC   P34490;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Serpentine receptor class X 45;
DE            Short=Protein srx-45;
GN   Name=srx-45; ORFNames=K01B6.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z22174; CAA80129.2; -; Genomic_DNA.
DR   PIR; S40760; S40760.
DR   RefSeq; NP_499049.2; NM_066648.2.
DR   AlphaFoldDB; P34490; -.
DR   SMR; P34490; -.
DR   PaxDb; P34490; -.
DR   EnsemblMetazoa; K01B6.2.1; K01B6.2.1; WBGene00005936.
DR   GeneID; 186838; -.
DR   KEGG; cel:CELE_K01B6.2; -.
DR   UCSC; K01B6.2; c. elegans.
DR   CTD; 186838; -.
DR   WormBase; K01B6.2; CE37779; WBGene00005936; srx-45.
DR   eggNOG; ENOG502SY4S; Eukaryota.
DR   GeneTree; ENSGT00970000195834; -.
DR   HOGENOM; CLU_059630_3_1_1; -.
DR   InParanoid; P34490; -.
DR   OMA; VSPPCEM; -.
DR   OrthoDB; 842624at2759; -.
DR   PhylomeDB; P34490; -.
DR   PRO; PR:P34490; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00005936; Expressed in larva and 3 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR019430; 7TM_GPCR_serpentine_rcpt_Srx.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF10328; 7TM_GPCR_Srx; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..361
FT                   /note="Serpentine receptor class X 45"
FT                   /id="PRO_0000070115"
FT   TRANSMEM        20..40
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        317
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   361 AA;  42095 MW;  96E7750FD5AA1D93 CRC64;
     MFQILMENVE VQHIDRIAAL LIFFTSFIGF ACNTFIAFYI RRLSLLRNSF GRLLQLQAAG
     DAVFVLVWAF YFAPVLFFDI KPLQSLAIAA RFAQLCLICY DISIYTHLVI SLNRFISLYF
     PTSYQNIFTE RFTTFLICSI IFVSFGFSWF LVIRDCQMGF SIPRWMLDYV SPPCEMINVY
     YAEFFRGLIV ISMFAITNSF TFCRMHMHNR KKQTATVFET TQQKKRRAVE TRFVQQVTMQ
     GLLYVIELVT YFYISLRFPV PLEPVELAKS SNRWPNFLLT TYAWILVHAL DGVITLIFNK
     QFRSVLRHPC RSQEALNISK TPSRRSRFTT NRDESNRKKS SILACTFISN SNTGYGSSVH
     V