ID   SRYA_DROME              Reviewed;         530 AA.
AC   P07666; Q9VAB4;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=Serendipity locus protein alpha;
GN   Name=Sry-alpha; Synonyms=Sry-a; ORFNames=CG17957;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Oregon-R;
RX   PubMed=3935797; DOI=10.1016/0022-2836(85)90265-7;
RA   Vincent A., Colot H.V., Rosbash M.;
RT   "Sequence and structure of the serendipity locus of Drosophila
RT   melanogaster. A densely transcribed region including a blastoderm-specific
RT   gene.";
RL   J. Mol. Biol. 186:149-166(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RX   PubMed=2166703; DOI=10.1101/gad.4.6.922;
RA   Schweisguth F., Lepesant J.-A., Vincent A.;
RT   "The serendipity alpha gene encodes a membrane-associated protein required
RT   for the cellularization of the Drosophila embryo.";
RL   Genes Dev. 4:922-931(1990).
CC   -!- FUNCTION: Required for the cellularization of the syncytial blastoderm
CC       embryo. Involved in the localization of the actin filaments just prior
CC       to and during plasma membrane invagination. Sry-alpha together with
CC       nullo and bnk may provide auxiliary functions, by acting both to
CC       stabilize a large and dynamic microfilament structure and regulate its
CC       functions. {ECO:0000269|PubMed:2166703}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:2166703}. Cell
CC       membrane {ECO:0000269|PubMed:2166703}; Peripheral membrane protein
CC       {ECO:0000269|PubMed:2166703}; Cytoplasmic side
CC       {ECO:0000269|PubMed:2166703}. Note=Inner membrane-associated and
CC       cytoplasmic. Colocalizes with the structural transitions in the
CC       microfilament network during cellularization.
CC   -!- TISSUE SPECIFICITY: Transient expression in blastoderm from nuclear
CC       cycle 11 to the onset of gastrulation. {ECO:0000269|PubMed:2166703}.
CC   -!- DEVELOPMENTAL STAGE: Transcript levels rise steadily during syncytial
CC       stages to reach a peak in early cycle 14 and then decline rapidly
CC       during cellularization. {ECO:0000269|PubMed:2166703}.
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DR   EMBL; X03121; CAA26897.1; -; Genomic_DNA.
DR   EMBL; AE014297; AAF56999.1; -; Genomic_DNA.
DR   EMBL; AY071374; AAL48996.1; -; mRNA.
DR   PIR; B23351; B23351.
DR   RefSeq; NP_001303490.1; NM_001316561.1.
DR   RefSeq; NP_524580.1; NM_079841.3.
DR   AlphaFoldDB; P07666; -.
DR   SMR; P07666; -.
DR   BioGRID; 68427; 37.
DR   DIP; DIP-19017N; -.
DR   IntAct; P07666; 29.
DR   STRING; 7227.FBpp0084923; -.
DR   PaxDb; P07666; -.
DR   DNASU; 43571; -.
DR   EnsemblMetazoa; FBtr0085557; FBpp0084923; FBgn0003510.
DR   EnsemblMetazoa; FBtr0346862; FBpp0312402; FBgn0003510.
DR   GeneID; 43571; -.
DR   KEGG; dme:Dmel_CG17957; -.
DR   CTD; 43571; -.
DR   FlyBase; FBgn0003510; Sry-alpha.
DR   VEuPathDB; VectorBase:FBgn0003510; -.
DR   eggNOG; ENOG502SBC0; Eukaryota.
DR   GeneTree; ENSGT00520000058538; -.
DR   HOGENOM; CLU_030377_0_0_1; -.
DR   InParanoid; P07666; -.
DR   OMA; ETIYLCF; -.
DR   PhylomeDB; P07666; -.
DR   Reactome; R-DME-418990; Adherens junctions interactions.
DR   Reactome; R-DME-5218920; VEGFR2 mediated vascular permeability.
DR   Reactome; R-DME-525793; Myogenesis.
DR   SignaLink; P07666; -.
DR   BioGRID-ORCS; 43571; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 43571; -.
DR   PRO; PR:P07666; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0003510; Expressed in germline cell (Drosophila) and 5 other tissues.
DR   Genevisible; P07666; DM.
DR   GO; GO:0032154; C:cleavage furrow; IDA:FlyBase.
DR   GO; GO:0005829; C:cytosol; IDA:FlyBase.
DR   GO; GO:0005886; C:plasma membrane; IDA:FlyBase.
DR   GO; GO:0007015; P:actin filament organization; IMP:FlyBase.
DR   GO; GO:0007349; P:cellularization; IMP:FlyBase.
DR   InterPro; IPR008837; Serendipity_A.
DR   Pfam; PF05482; Serendipity_A; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Developmental protein; Membrane;
KW   Reference proteome.
FT   CHAIN           1..530
FT                   /note="Serendipity locus protein alpha"
FT                   /id="PRO_0000072197"
SQ   SEQUENCE   530 AA;  59385 MW;  EC576378256193FB CRC64;
     MEQLLAQLHT CSELIAEGYS STGNIGWLNE FCATFLDFAS DLKARLPEVA PSGANLDVET
     IFLCLTQVVT CITHLERTIS MEAPHMTRQH FLDRLDWCLR RLLVSLTQLE GNVTPVKNLE
     DHSFVELMDL ALDHLDDYME KLAQQRNNSL HILEESFTED TYQLASIVNH IVRHALAFAN
     VAIHSDKKAL TALCETLLAE CATFHEEAGE PNSGHRKLEA LSLERALYAL ESFLNEALLH
     LLFVSLIDLE NASVEKLKDA LQRDPAGAQE LISAFDTNMD RIQQIGVLAI AFSQDIKTKT
     IVRSCLASLE SLDACIVPAL QLPESTSSAH HAEVLQEHFN QELLIFRNVI HEIIDSCSLI
     NNYLDMLGER IHVQDKSHLK LIVQRGGVVV DHFRLPVNYS GLSEDGKRVH KDLILILREC
     QAVVNLDVPV DPKRIVKRLK ILYSVLAKLR DLICRDNLEP DSSVASEAQV PSSATRTFVR
     SSRSFGKRHR SFVKQTGNCS VFGPQDSLAE SGHSESDLIS FQITEILRLD